[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647842":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":50,"collaborators":24,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":24,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":24,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":80,"whyStopped":24,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Heated Humidifier (HH) Group","EXPERIMENTAL","Patients in this group will receive active airway humidification using an electric heated humidifier. The device comprises a plastic humidification chamber with a metallic base, containing sterile water, placed on top of an electric heater plate connected to the inspiratory limb of the ventilator circuit.",[13],"Device: Airway Humidification Device",{"label":15,"type":10,"description":16,"interventionNames":17},"Heat and Moisture Exchanger (HME) Group","Patients in this group will receive passive airway humidification using a disposable heat and moisture exchanger (HME), with or without particle filters, attached directly to the patient's artificial airway to recycle exhaled heat and moisture.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Airway Humidification Device","Application of either active heated humidifiers or passive heat-and-moisture exchangers to provide adequate gas humidification for patients on prolonged mechanical ventilation.",[15,9],null,[26],{"name":27,"affiliation":28,"role":29},"Mervat Abdel Aziz, PhD","Faculty of Nursing, Assiut University","STUDY_CHAIR",[31],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Mostafa MA Ali, MSc Candidate","CONTACT","+201091423626","Mostafa1156@aun.edu.eg",[37],{"facility":38,"status":24,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":24},"Trauma Intensive Care Units, Assiut University Hospital","Asyut","Asyut Governorate","71515","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.18368,27.18096,{"lat":48,"lon":47},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Mostafa Muhammad Ahmad Ali","Assistant lecturer of Critical Care and Emergency Nursing","100647842","humidification-effects-on-airway-complications-and-clinical-outcomes-in-trauma-icu-patients-on-mechanical-ventilation-100647842",false,"NCT07713238","Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical Ventilation","Effect of Active Versus Passive Humidification on Airway Complications and Clinical Outcomes in Trauma ICU Patients With Prolonged Mechanical Ventilation","Inclusion Criteria\n\n1. Adult age 18-65 years.\n2. Trauma ICU patients receiving invasive mechanical ventilation.\n3. Anticipated to require prolonged mechanical ventilation, defined as ≥7 days of invasive ventilatory support\n\nExclusion Criteria:\n\n1. Immunosuppression such as HIV, cancer or AIDS.\n2. Blood leukocyte count \\\u003C1,000 cells\u002Fmm3.\n3. Withdrawal of life-sustaining treatment within 5 days.\n4. Use of HME in conjunction with an HH.\n5. Contraindications of HME including body temperature \\\u003C 32°C, copious, thick, or bloody secretions, significant air leak (exhaled VT \\>70% of VT inspired) or broncopleural fistula","ALL","18 Years","65 Years",{"count":65,"type":66},162,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study compares the effects of two primary airway humidification methods-active heated humidifiers (HHs) and passive heat-and-moisture exchangers (HMEs)-on trauma intensive care unit (ICU) patients requiring prolonged mechanical ventilation. Adequate humidification is essential during mechanical ventilation because artificial airways bypass the body's natural ability to warm and moisten inhaled air. While existing guidelines show no overall superiority of one method over the other in general ICU populations, trauma patients present unique challenges, such as thick or bloody secretions, which may lead to airway obstructions and affect the performance of these devices.\n\nThe main purpose of this randomized controlled trial is to evaluate how active versus passive humidification impacts airway complications (such as secretion viscosity and tube obstruction) and clinical outcomes (including ventilator-associated pneumonia, duration of mechanical ventilation, length of ICU stay, and mortality rates). A total of 162 adult trauma patients at Assiut University Hospital will be randomly assigned to either the HH group or the HME group to determine if there are significant clinical differences between the two methods in this specific patient population.",[72,73,74],"Respiratory Insufficiency","Wounds and Injuries","Critical Illness",[76,77,78,79],"Heated Humidifier","Heat and Moisture Exchanger","Airway Complications","Mechanical Ventilation","NOT_YET_RECRUITING","2026-07-14",{"date":83,"type":84},"2026-07-20","ACTUAL",{"date":86,"type":66},"2026-07-12",{"date":88,"type":66},"2027-05-12",{"name":5,"class":6},1]