[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652184":3},{"organization":4,"outcomesModule":7,"designInfo":42,"detailedDescription":49,"studyPopulation":41,"armGroups":50,"interventions":57,"overallOfficials":63,"centralContacts":70,"locations":75,"responsibleParty":89,"collaborators":41,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":41,"eligibilityCriteria":98,"healthyVolunteers":94,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":41,"studyType":105,"phases":106,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":116,"whyStopped":41,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Cairo University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":41},[9,13],{"measure":10,"description":11,"timeFrame":12},"Percentage of Root Coverage","Percentage of root coverage will be calculated using the following formula: (Initial Recession Depth - Post-Treatment Recession Depth) \u002F Initial Recession Depth × 100.","Baseline, 1 month, 3 months, and 6 months",{"measure":14,"description":15,"timeFrame":16},"Clinical Attachment Level (CAL) Gain","Clinical attachment level will be measured in millimetres using a UNC-15 periodontal probe","Baseline, 3 months, and 6 months",[18,21,24,27,30,33,37],{"measure":19,"description":20,"timeFrame":16},"Recession Depth","Gingival recession depth will be measured in millimeters using a UNC-15 periodontal probe",{"measure":22,"description":23,"timeFrame":16},"Recession Width","Gingival recession width will be measured in millimeters using a UNC-15 periodontal probe.",{"measure":25,"description":26,"timeFrame":16},"Gingival Thickness","Gingival thickness will be measured in millimeters using an endodontic file",{"measure":28,"description":29,"timeFrame":16},"Probing Depth","Probing depth will be measured in millimeters using a UNC-15 periodontal probe.",{"measure":31,"description":32,"timeFrame":16},"Width of Keratinized Tissue","Keratinized tissue width will be measured in millimeters using a UNC-15 periodontal probe",{"measure":34,"description":35,"timeFrame":36},"Post-Operative Pain","Post-operative pain will be assessed using a Visual Analogue Scale (VAS) questionnaire, with scores ranging from 1 to 10","1 week post-surgery",{"measure":38,"description":39,"timeFrame":40},"Patient Esthetic Satisfaction","Patient esthetic satisfaction will be assessed using a Visual Analogue Scale (VAS) questionnaire, with scores ranging from 1 to 10","3 months and 6 months",null,{"allocation":43,"interventionModel":44,"interventionModelDescription":45,"primaryPurpose":46,"observationalModel":41,"timePerspective":41,"maskingInfo":47},"NA","SINGLE_GROUP","All participants will receive the same intervention consisting of coronally advanced flap and connective tissue graft combined with hyaluronic acid and polynucleotides.","TREATMENT",{"masking":48,"maskingDescription":41,"whoMasked":41},"NONE","Patients with RT II gingival recession will be treated using a coronally advanced flap combined with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing. Patients will be followed for 6 months. Clinical measurements will include recession depth and width, percentage of root coverage, clinical attachment level, gingival thickness, probing depth, keratinized tissue width, post-operative pain, and patient esthetic satisfaction.",[51],{"label":52,"type":53,"description":54,"interventionNames":55},"CAF + CTG + Hyaluronic Acid and Polynucleotides","EXPERIMENTAL","Participants with RT II gingival recession will receive coronally advanced flap surgery with a de-epithelialized connective tissue graft combined with hyaluronic acid and polynucleotides.",[56],"Procedure: Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid\u002FPolynucleotides",[58],{"type":59,"name":60,"description":61,"armGroupLabels":62,"otherNames":41},"PROCEDURE","Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid\u002FPolynucleotides","A coronally advanced flap will be performed with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing",[52],[64,67],{"name":65,"affiliation":5,"role":66},"HASSAN NIDAL FANDI, BDS","PRINCIPAL_INVESTIGATOR",{"name":68,"affiliation":5,"role":69},"Dr.Manal Hosny","STUDY_CHAIR",[71],{"name":65,"role":72,"phone":73,"phoneExt":41,"email":74},"CONTACT","+201011066726","hassan.fandi@dentistry.cu.edu.eg",[76],{"facility":77,"status":41,"city":78,"state":41,"zip":41,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"Faculty of Dentistry, Cairo University","Cairo","Egypt","EG",{"type":82,"coordinates":83},"Point",[84,85],31.24967,30.06263,{"lat":85,"lon":84},[88],{"name":65,"role":72,"phone":73,"phoneExt":41,"email":74},{"type":66,"investigatorFullName":90,"investigatorTitle":91,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"hassan nidal fandi","Master Student - Periodontology","100652184","hyaluronic-acid-and-polynucleotides-with-connective-tissue-graft-and-coronally-advanced-flap-for-rt-ii-gingival-recession-100652184",false,"NCT07771244","Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession","Assessment of Injectable Hyaluronic Acid Combined With Polynucleotides With Coronally Advanced Flap and Connective Tissue Graft in Treatment of RT II Gingival Recession Defects for Covering Gingival Recession","Inclusion Criteria:\n\n* Patients with RT II gingival recession.\n* Age range: 15-60 years.\n* Systemically healthy patients with no contraindications to surgery.\n* Patients who have not had previous periodontal surgery in the area of treatment.\n\nExclusion Criteria:\n\n* Periodontitis.\n* Active systemic disease affecting wound healing.\n* Pregnancy or breastfeeding.\n* Improperly aligned teeth or teeth with cervical restorations or crowns.\n* Non-carious cervical lesions","ALL","15 Years","60 Years",{"count":103,"type":104},12,"ESTIMATED","INTERVENTIONAL",[43],"This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession. Twelve patients will be included and followed for 6 months. Clinical outcomes will include percentage of root coverage, clinical attachment level gain, gingival thickness, probing depth, width of keratinized tissue, post-operative pain, and patient aesthetic satisfaction.",[109],"RT II Gingival Recession",[111,109,112,113,114,115],"Gingival Recession","Hyaluronic Acid","Polynucleotides","Coronally Advanced Flap","Connective Tissue Graft","NOT_YET_RECRUITING","2026-08-20",{"date":119,"type":120},"2026-08-21","ACTUAL",{"date":122,"type":104},"2026-09-01",{"date":124,"type":104},"2027-03-01",{"name":5,"class":6},1]