[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557455":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":37,"responsibleParty":55,"collaborators":31,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":31,"enrollmentInfo":67,"targetDuration":31,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":39,"whyStopped":31,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Jonsson Comprehensive Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Hypofractionated External beam Radiotherapy","EXPERIMENTAL","5 daily treatment sessions of MRI or CT-Guided Stereotactic Body Radiation Therapy (SBRT).",[13],"Radiation: External beam Radiotherapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"RADIATION","External beam Radiotherapy","Five fractions of radiation therapy using adaptive planning and CT or MRI guidance (6 Gy per fraction) delivered once every other day excluding weekends and holidays",[9],[9],[22],{"name":23,"affiliation":24,"role":25},"Puja S. Venkat, MD","University of California at Los Angeles","PRINCIPAL_INVESTIGATOR",[27,33],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Christy Palodichuk","CONTACT","310-794-2971",null,"cpalodichuk@mednet.ucla.edu",{"name":34,"role":29,"phone":35,"phoneExt":31,"email":36},"Vincent Basehart","310-267-8954","vbasehart@mednet.ucla.edu",[38],{"facility":24,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Los Angeles","California","90095","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-118.24368,34.05223,{"lat":49,"lon":48},[52,53,54],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},{"name":34,"role":29,"phone":35,"phoneExt":31,"email":36},{"name":23,"role":25,"phone":31,"phoneExt":31,"email":31},{"type":56,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100557455","hypofractionated-external-beam-radiotherapy-with-adaptive-planning-for-endometrial-and-cervical-cancers-100557455",false,"NCT06538337","Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers","Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers (HERA Trial)","HERA","Inclusion Criteria:\n\n* Histologically confirmed endometrial or cervical cancer\n* Surgical resection of the primary tumor\n* International Federation of Gynecology and Obstetrics (FIGO) Stage IA-IVB endometrial cancer OR FIGO Stage IA-IIA cervical cancer that meets indications for receiving adjuvant pelvic radiotherapy alone as standard of care\n* Age ≥ 18 years old\n* Karnofsky performance status (KPS) ≥ 60 or Eastern Cooperative Oncology Group (ECOG) 0-2\n\nExclusion Criteria:\n\n* Must not meet indications for receiving concurrent chemotherapy as standard of care\n* Active treatment of a separate malignancy\n* History of prior irradiation to the area to be treated","FEMALE","18 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"NA","After surgery to remove the main endometrial and\u002For cervical tumor, most women receive radiation therapy. This study uses hypo-fractionated radiation therapy, which is a type of radiation therapy in which the total prescribed dose of radiation is delivered in fewer but larger doses than conventional or standard radiotherapy.\n\nThis research study aims to determine if hypo-fractionated radiation therapy given after surgery can improve treatment tolerability (i.e., fewer treatments) with comparable side effects.\n\nParticipants will be in the study for about 5 years:\n\nRadiation therapy:\n\n* 5 daily treatment sessions of MRI or CT-Guided Stereotactic Body Radiation Therapy (SBRT).\n* Each treatment session will occur on a weekday (typically consecutive weekdays) and will last approximately an hour.\n\nTreatment Follow-Up:\n\n* Check-up Appointment and answer questions at 3 months post RT\n* Check-up Appointments with physical exam every 6 months (+\u002F- 4 weeks) for up to 5 years.",[75,76],"Endometrial Cancer","Cervical Cancer",[78,79,80],"endometrial","cervical","SBRT","2026-08-18",{"date":83,"type":84},"2026-08-20","ACTUAL",{"date":86,"type":84},"2024-07-24",{"date":88,"type":69},"2032-07-26",{"name":5,"class":6},1]