[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659322":3},{"organization":4,"outcomesModule":7,"designInfo":19,"detailedDescription":11,"studyPopulation":22,"armGroups":23,"interventions":28,"overallOfficials":33,"centralContacts":38,"locations":46,"responsibleParty":59,"collaborators":11,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":11,"studyType":75,"phases":11,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":49,"whyStopped":11,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Compare the efficacy of PC-CTA and of conventional CTA in assessing the percent atheroma volume (PAV) using the output of the NIRS-IVUS analysis as the reference standard",null,"After each patient has had coronary angiography",[14,17],{"measure":15,"description":11,"timeFrame":16},"Identify the optimal reconstruction method of PC-CTA data for measuring the PAV in the studied segment using the NIRS-IVUS estimations as the reference standard.","After each patient has had coronary angiography.",{"measure":18,"description":11,"timeFrame":16},"Compare the accuracy of PC-CTA and conventional CTA in measuring flow patterns.",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":20,"timePerspective":21,"maskingInfo":11},"COHORT","PROSPECTIVE","Patients with a chronic coronary syndrome",[24],{"label":25,"type":11,"description":11,"interventionNames":26},"Patients with Chronic Coronary Syndrome",[27],"Other: observational study",[29],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"observational study","Observation study comparing Photon-counting CT with intravascular coronary imaging in patients with chronic coronary syndrome",[25],[34],{"name":35,"affiliation":36,"role":37},"Christos V Bourantas, MD PhD","Barts Health NHS Trust and Queen Mary University of London","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":11,"email":43},"Ameer Hamid A Khan, MBBS BSc MSc","CONTACT","447780356028","a.h.a.khan@qmul.ac.uk",{"name":35,"role":41,"phone":11,"phoneExt":11,"email":45},"cbourantas@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":11,"zip":11,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":11},"William Harvey Research Institute, Barts and The London, Queen Mary University of London","RECRUITING","London","United Kingdom","UK",{"type":54,"coordinates":55},"Point",[56,57],-0.12574,51.50853,{"lat":57,"lon":56},{"type":60,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100659322","identification-of-lesion-characteristics-in-coronary-plaques-using-multimodality-intravascular-imaging-and-novel-photon-counting-ct-in-stable-angina-100659322",false,"NCT07864025","Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina","Next Generation Coronary Plaque Characterisation and Computation of Flow Patterns: Photon-Counting Computed Tomography Coronary Angiography Versus State-of-the-Art Multimodality Intravascular Imaging","ILUMINA","Inclusion Criteria:\n\n* Able and willing to give informed consent\n* Between ages 18-79\n* Patients with a stable coronary syndrome that had recent PC-CTA showing at least one lesion requiring further evaluation with intravascular imaging or fractional flow reserve and is considered suitable for PCI under IVUS guidance\n\nExclusion Criteria:\n\n* Unable to or unwilling to give informed consent\n* Age \\>80 years\n* Recent acute coronary syndrome within \\\u003C 3 months\n* Renal failure (eGFR \\\u003C60ml\u002Fmin\u002F1.73m²)\n* History of previous coronary artery bypass surgery\n* Decompensated heart failure, or left ventricular ejection fraction ≤30%\n* Previous heart transplantation\n* Intravenous contrast allergy\n* Unable to receive treatment with aspirin, heparin, or thienopyridines\n* Anticipated life expectancy \\\u003C1 year\n* Pregnancy\n* Patient that requires surgical revascularisation\n* Extensive coronary artery disease (i.e. multiple chronic total occlusions) or tortuous coronary anatomy that does not allow assessment of the coronary arteries with NIRS-IVUS imaging","ALL","18 Years","79 Years",{"count":73,"type":74},70,"ESTIMATED","OBSERVATIONAL","Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK. Despite existing therapies, adverse cardiovascular events remains high, especially in patients who have already had a heart attack, as some of these patients have aggressive atherosclerotic disease. If we could identify these vulnerable patients, then in wider clinical practice in the future we might be able to treat them better with new therapies that can otherwise be expensive or come with a risk of side-effects. Traditionally, the assessment of atherosclerotic disease and the identification of the plaques that will cause heart attacks is performed using invasive imaging - imaging taken by passing a wire into the arteries of the heart that has a camera on its tip. Invasive imaging, however, can be used only in patients with symptoms and has risks. Photon counting (PC) CT is a new CT system that has image quality comparable to invasive imaging and can be used in the community to examine individuals with stable angina symptoms. In this study we aim to compare how well PC-CT detects high-risk plaques compared with invasive imaging and in due course develop a platform that will expedite the analysis of CT images to allow its broad use in the clinical practice.",[78,79,80],"Coronary Artery Disease (CAD)","Stable Angina Pectoris","Ischaemic Heart Disease (IHD)",[82,83,84,85,86,87,78],"Photon-counting CT","Coronary plaque characterization","Lipid-rich plaque","Intravascular ultrasound","Near-infrared spectroscopy","Vulnerable plaque","2026-10-06",{"date":90,"type":91},"2026-10-07","ACTUAL",{"date":93,"type":91},"2026-08-19",{"date":95,"type":74},"2029-04-03",{"name":5,"class":6},1]