[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624622":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":38,"centralContacts":43,"locations":53,"responsibleParty":70,"collaborators":26,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":26,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":56,"whyStopped":26,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,15],{"label":9,"type":6,"description":10,"interventionNames":11},"Case","Patient with a Lipodystrophy Familial Partial due to a known pathogenic variant of the LMNA gene",[12,13,14],"Genetic: Genetic analysis","Other: Biological analysis","Other: imaging test",{"label":16,"type":6,"description":17,"interventionNames":18},"Control","Patient consulting for polycystic ovary syndrome in day hospital matched on age +\u002F-5 years and BMI+\u002F-5 kg\u002Fm2",[19],"Other: Standard intervention",[21,27,31,35],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"GENETIC","Genetic analysis","Analyses of the insulin resistance and lipodystrophy gene panel revealed pathogenic or highly susceptible variants in control PCOS patients",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Biological analysis","Measurement of adipokines",[9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"imaging test","DEXA (Dual-Energy X-ray Absorptiometry)",[9],{"type":6,"name":36,"description":36,"armGroupLabels":37,"otherNames":26},"Standard intervention",[16],[39],{"name":40,"affiliation":41,"role":42},"Sophie LAMOTHE","APHP","PRINCIPAL_INVESTIGATOR",[44,50],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"Sophie LAMOTHE, Doctor","CONTACT","0149282406","+33","sophie.lamothe@aphp.fr",{"name":51,"role":46,"phone":47,"phoneExt":48,"email":52},"Camille VATIER, Doctor","camille.vatier@aphp.fr",[54],{"facility":55,"status":56,"city":57,"state":26,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Service Endocrinologie, Hôpital St Antoine","RECRUITING","Paris","75012","France","FR",{"type":62,"coordinates":63},"Point",[64,65],2.3488,48.85341,{"lat":65,"lon":64},[68,69],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},{"name":51,"role":46,"phone":47,"phoneExt":48,"email":52},{"type":71,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100624622","identification-of-women-with-severe-insulin-resistant-syndromes-of-genetic-origin-among-patients-with-classic-polycystic-ovary-syndrome-pcos-100624622",false,"NCT07412028","Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With \"Classic\" Polycystic Ovary Syndrome (PCOS)","ANDROLIPO","Inclusion Criteria:\n\n* Women aged ≥ 18 years and \\\u003C 45 years ;\n* Discontinuation of estrogen-progestin therapyfor at least 3 months ;\n* Signed informed consent ;\n* Social security affiliation.\n\nCase (n=25):\n\n\\- Patient with a lipodystrophic syndrome due to a known pathogenic variant of the LMNA gene.\n\nControl (n=50), :\n\n\\- patient consulting for polycystic ovary syndrome (PCOS according to the Rotterdam criteria) in day hospital matched on age +\u002F-5 years and BMI+\u002F-5 kg\u002Fm2.\n\nExclusion Criteria:\n\n* \\- Severe renal insufficiency (GFR \\\u003C 30 ml\u002Fmin) ;\n* Hepato-cellular insufficiency (TP \\\u003C 50%) ;\n* Taking corticosteroids or antiretrovirals ;\n* Menopausal women ;\n* Taking estrogen-progestin therapy;\n* Diabetic patients on insulin : type 1 diabetes or pancreatectomised patients\n* Other known causes of hyperandrogenism (21-hydroxylase block, Cushing's syndrome, ovarian tumor).\n* Pregnant woman\n* Breastfeeding woman","FEMALE","18 Years","45 Years",{"count":83,"type":84},81,"ESTIMATED","INTERVENTIONAL",[87],"NA","Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+\u002F- 5 years) and Body mass index (+\u002F- 5kg\u002Fm2).",[90,91,92],"Polycystic Ovary Syndrome","Familial Partial Lipodystrophy","LMNA (LaMin Nuclear A) Related Disorders",[90,91,94],"LMNA related disorders","2026-08-07",{"date":97,"type":98},"2026-08-10","ACTUAL",{"date":100,"type":98},"2026-07-21",{"date":102,"type":84},"2028-01",{"name":5,"class":6},1]