[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631899":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":32,"responsibleParty":53,"collaborators":55,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":18,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":18,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":82,"whyStopped":18,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Calf muscle strengthening","EXPERIMENTAL","Older adults will complete a 3x\u002Fwk, 12 week calf strengthening exercise over zoom. The intervention will be delivered in small groups. Older adult baseline data will be compared to post-intervention data to understand the impact of exercise on aging muscle and fat within the muscle",[13],"Other: Calf muscle strengthening",[15],{"type":6,"name":9,"description":16,"armGroupLabels":17,"otherNames":18},"The calf intervention will be delivered 3x\u002Fwk for 12 weeks over zoom, in small groups. There are 3 exercises 1) standing heel rise, 2) seated heel rise, and 3) long sitting ankle plantarflexion. The exercises will be overloaded using a weighted vest, body weight, and\u002For theraband. Exercises will be progressed as strength improves.",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Gretchen Meyer, PhD","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Mary Hastings, PT, DPT, MSCI, ATC","CONTACT","1 314-286-1433","hastingsmk@wustl.edu",{"name":21,"role":26,"phone":30,"phoneExt":18,"email":31},"1-314-286-1456","meyerg@wustl.edu",[33],{"facility":34,"status":18,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Washington University","St Louis","Missouri","63108","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-90.19789,38.62727,{"lat":44,"lon":43},[47,49,50,52],{"name":25,"role":26,"phone":48,"phoneExt":18,"email":28},"314-286-1433",{"name":18,"role":26,"phone":18,"phoneExt":18,"email":28},{"name":25,"role":51,"phone":18,"phoneExt":18,"email":18},"SUB_INVESTIGATOR",{"name":21,"role":22,"phone":18,"phoneExt":18,"email":18},{"type":54,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[56],{"name":57,"class":58},"National Institute on Aging (NIA)","NIH","100631899","imat-quality-in-aging-100631899",false,"NCT07506681","IMAT Quality in Aging","Targeting Intramuscular Adipose Quality in Aging","Inclusion Criteria:\n\n* Rapid Assessment of Physical Activity scores between 3 and 5\n* Able to don and doff the weighted vest\n* Access to a smart phone and ability to navigate the phone to enter and manage a zoom intervention\n* Commitment and availability to attend a virtual 40-minute intervention 3x per week for 12 weeks\n\nExclusion Criteria:\n\n* Contraindications to radiation exposure (e.g. Women who are pregnant, previous high radiation exposure)\n* Bleeding disorders\n* Lower extremity trauma\u002Fsurgery\u002Finjury or neuropathy that would impact muscle structure and function or ability to complete exercise intervention\n* Diabetes mellitus, cardiovascular disease, peripheral vascular disease, cancer, stage 4 hypertension, anemia, connective tissue disorder\n* Neurological disorder (e.g. stroke, Parkinson's disease, multiple sclerosis, spinal cord injury)\n* Medications: insulin, glucagon-like peptide-1 (GLP1) agonists, sex hormone replacement therapy, chronic NSAIDs, anticoagulation therapy, cholesterol lowering medications such as statins\n* Unable to safely perform the progressive resistance exercise (e.g. Vestibular or balance issues that make performing the intervention unsafe, severe osteoporosis or general fragility that limits weighted vest tolerance)",true,"ALL","65 Years","80 Years",{"count":71,"type":72},16,"ESTIMATED","INTERVENTIONAL",[75],"NA","This study will test the central hypothesis that fat within the muscle, or intramuscular adipose tissue (IMAT), exhibits elevated damage and pro-inflammatory signaling with aging, both of which are reduced by progressive resistance exercise (PRE). Sixteen older adults 65-80 years old will be recruited and complete a 12 week calf PRE intervention. Calf muscle strength, composition (measured by computed tomography) and muscle biopsies will be collected before and after the intervention. Histology, transcriptomic and secretomic tests will be completed to assess signs of damage and inflammation.",[78],"Aging",[80,81],"aging","muscle","NOT_YET_RECRUITING","2026-08-17",{"date":85,"type":86},"2026-08-18","ACTUAL",{"date":88,"type":72},"2026-10-01",{"date":90,"type":72},"2028-01",{"name":5,"class":6},1]