[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657271":3},{"organization":4,"outcomesModule":7,"designInfo":13,"detailedDescription":11,"studyPopulation":11,"armGroups":19,"interventions":32,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":42,"collaborators":11,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":11,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":11,"enrollmentInfo":55,"targetDuration":11,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":75,"whyStopped":11,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":11},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Total Length of Hospital Stay",null,"Up to 3 months",{"allocation":14,"interventionModel":15,"interventionModelDescription":11,"primaryPurpose":16,"observationalModel":11,"timePerspective":11,"maskingInfo":17},"NON_RANDOMIZED","PARALLEL","TREATMENT",{"masking":18,"maskingDescription":11,"whoMasked":11},"NONE",[20,26],{"label":21,"type":22,"description":23,"interventionNames":24},"Group A: Immediate Laparoscopic Appendectomy","EXPERIMENTAL","Patients undergo immediate laparoscopic appendectomy within 24 hours of admission. The procedure utilizes a standard 3-port laparoscopic technique (one 10 mm umbilical camera port and two 5 mm working ports), blunt and sharp adhesiolysis to isolate the inflamed appendix, appendix resection via endoloop or endoscopic stapler, warm saline peritoneal lavage (3-5 L), and abdominal drain placement if indicated.",[25],"Procedure: Immediate Laparoscopic Appendectomy",{"label":27,"type":28,"description":29,"interventionNames":30},"Group B: Interval Laparoscopic Appendectomy","ACTIVE_COMPARATOR","Patients receive initial conservative medical treatment with intravenous antibiotics (third-generation cephalosporin, metronidazole, and amikacin) along with analgesics, monitored via clinical examination and ultrasound every 48 hours until symptom resolution and discharge. Patients subsequently undergo elective interval laparoscopic appendectomy 6 to 8 weeks later using the same standard 3-port technique.",[31],"Procedure: Interval Laparoscopic Appendectomy",[33,38],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"PROCEDURE","Immediate Laparoscopic Appendectomy","Laparoscopic appendectomy performed within 24 hours of admission. The procedure is executed using a standard 3-port technique (one 10 mm umbilical camera port and two 5 mm working ports). It includes careful blunt and sharp adhesiolysis to identify and mobilize the appendix, appendectomy using an endoloop ligature or endoscopic stapler, peritoneal lavage with 3-5 liters of warm normal saline, and abdominal drain placement when clinically indicated.",[21],{"type":34,"name":39,"description":40,"armGroupLabels":41,"otherNames":11},"Interval Laparoscopic Appendectomy","Initial conservative medical management with intravenous antibiotics (third-generation cephalosporin, metronidazole, and amikacin) and analgesics, monitored clinically and via ultrasonography every 48 hours until clinical improvement and discharge. Patients undergo elective interval laparoscopic appendectomy 6 to 8 weeks later using the standard 3-port laparoscopic technique.",[27],{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Youhanna Bahgat Hosny Loundy","Resident of General Surgery","100657271","immediate-laparoscopic-appendectomy-versus-interval-laparoscopic-appendectomy-for-early-appendicular-mass-100657271",false,"NCT07837531","Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass","Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass: A Comparative Study","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Clinical diagnosis of appendicular mass confirmed by abdominal ultrasonography and\u002For abdominal CT scan\n* Presentation within 72 hours of symptom onset\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Generalized peritonitis or perforation with free intraperitoneal air\n* Appendicular abscess \\> 5 cm not amenable to percutaneous drainage\n* History of previous abdominal surgeries (contraindication to laparoscopy)\n* American Society of Anesthesiologists (ASA) physical status classification ≥ IV\n* Severe shock or sepsis requiring preoperative intensive care unit (ICU) admission\n* Suspected cecal malignancy or colonic neoplasm\n* Pregnancy","ALL","18 Years",{"count":56,"type":57},100,"ESTIMATED","INTERVENTIONAL",[60],"NA","This study compares two standard treatment approaches for patients presenting with an appendicular mass, an inflammatory lump that forms when the appendix becomes severely inflamed and walled off by surrounding abdominal tissues.\n\nThe traditional treatment involves conservative medical therapy using intravenous antibiotics followed by an elective interval surgery to remove the appendix 6 to 8 weeks later. Alternatively, advances in minimally invasive surgery allow for an immediate keyhole operation (laparoscopic appendectomy) performed during the initial hospital admission. The goal of this study is to evaluate which approach leads to shorter total hospital stays, faster recovery, and fewer complications.\n\nParticipants will be assigned to one of two treatment groups:\n\n* Group A (Immediate Laparoscopic Appendectomy): Participants undergo laparoscopic surgery to remove the appendix within 24 hours of hospital admission.\n* Group B (Interval Laparoscopic Appendectomy): Participants receive initial intravenous antibiotics in the hospital until symptoms resolve. After discharge, they return 6 to 8 weeks later for elective laparoscopic surgery.\n\nParticipants in both groups will be monitored throughout their hospital stay and will attend follow-up visits at 1, 3, and 6 months postoperatively to assess recovery, wound healing, and any potential complications.",[63,64,65,66],"Appendicular Mass","Acute Appendicitis","Appendiceal Phlegmon","Appendicitis With Periappendicular Abscess",[68,69,70,71,72,73,74],"Immediate appendectomy","Interval appendectomy","Laparoscopic appendectomy","Conservative management","Plastron appendicitis","Minimally invasive surgery","Complicated appendicitis","NOT_YET_RECRUITING","2026-09-18",{"date":78,"type":79},"2026-09-23","ACTUAL",{"date":81,"type":57},"2026-10",{"date":83,"type":57},"2027-11",{"name":5,"class":6}]