[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648951":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":37,"locations":43,"responsibleParty":62,"collaborators":36,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":36,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":36,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":91,"whyStopped":36,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Gadjah Mada University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Carbohydrate Loading (CL)","EXPERIMENTAL","Participants receive 3 mL\u002Fkg body weight of a carbohydrate drink 2 hours before anesthesia induction.",[13],"Dietary Supplement: Carbohydrate",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Loading (PL)","PLACEBO_COMPARATOR","Participants receive 3 mL\u002Fkg body weight of plain water 2 hours before surgery, following the same timing and fasting protocol as the experimental group",[19],"Other: placebo solution",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Carbohydrate","Participants receive 3 mL\u002Fkg body weight of a carbohydrate drink 2 hours before anesthesia induction. The drink is used to lower insulin resistance and improve perioperative recovery.",[9],[27,28],"preoperative carbohydrate loading drink","Oral carbohydrate drink",{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"placebo solution","Participants receive 3 mL\u002Fkg body weight of plain water 2 hours before surgery, following the same timing and fasting protocol as the experimental group.",[15],[34,35],"Clear water placebo","Plain water",null,[38],{"name":39,"role":40,"phone":41,"phoneExt":36,"email":42},"Rifdhani Fakhrudin Nur","CONTACT","+6281390051037","rifdhani@mail.ugm.ac.id",[44],{"facility":45,"status":36,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RSUP Dr. Sardjito","Sleman","D.I. Yogyakarta","55281","Indonesia","ID",{"type":52,"coordinates":53},"Point",[54,55],110.35556,-7.71556,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":60,"phoneExt":36,"email":61},"Instalasi Diklat RSUP Dr. Sardjito","+628112910226","diklat@sardjitohospital.co.id",{"type":63,"investigatorFullName":39,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"SPONSOR_INVESTIGATOR","Principal Investigator","100648951","impact-of-preoperative-oral-carbohydrate-loading-on-insulin-resistance-in-pediatric-cardiac-surgery-patients-100648951",false,"NCT07729280","Impact of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Pediatric Cardiac Surgery Patients","The Effect of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Pediatric Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 2-16 years.\n* ASA physical status 2 or 3\n* Good tolerance of enteral feeding\n\nExclusion Criteria:\n\n* History of type 1 diabetes mellitus.\n* History of thyroid insufficiency treated with thyroid medication.\n* History of adrenal insufficiency treated with corticosteroids.\n* History of gastroesophageal reflux disease.\n* Patients receiving preoperative parenteral nutrition.\n* Emergency or urgent cardiac surgery.","ALL","2 Years","16 Years",{"count":76,"type":77},44,"ESTIMATED","INTERVENTIONAL",[80],"NA","Surgical stress and preoperative fasting can induce insulin resistance, characterized by impaired cellular response to insulin and resulting hyperglycemia. In pediatric patients undergoing cardiac surgery, this metabolic stress response may negatively affect postoperative recovery. Although preoperative oral carbohydrate loading, defined as administering a carbohydrate-rich beverage before surgery rather than prolonged fasting, has demonstrated efficacy in reducing postoperative insulin resistance in adults, evidence supporting its use in pediatric cardiac surgery remains limited.\n\nThis randomized controlled trial aims to determine whether preoperative oral carbohydrate loading reduces perioperative insulin resistance, as measured by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), in pediatric patients undergoing cardiac surgery. The study will compare outcomes between children who receive an oral carbohydrate beverage prior to surgery and those who follow standard preoperative fasting protocols.",[83,84,85],"Cardiac Surgery","Insulin Resistance","Pediatric Cardiac Surgery",[87,88,89,90],"Cardiac surgery","Carbohydrate loading","Insulin resistance","Glycemic variability","NOT_YET_RECRUITING","2026-07-24",{"date":94,"type":95},"2026-07-27","ACTUAL",{"date":97,"type":77},"2026-08-25",{"date":99,"type":77},"2026-11-01",{"name":39,"class":6},1]