[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599265":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":35,"centralContacts":39,"locations":48,"responsibleParty":65,"collaborators":27,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":27,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":27,"enrollmentInfo":77,"targetDuration":27,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":27,"overallStatus":50,"whyStopped":27,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Guided bone regeneration","ACTIVE_COMPARATOR","Guided bone regeneration with collagen membrane",[13,14],"Procedure: Dental implant placement","Procedure: Guided bone regeneration with collagen membrane",{"label":16,"type":17,"description":18,"interventionNames":19},"Guided bone regeneration with Phenotype modification.","EXPERIMENTAL","Guided bone regeneration with an allogenic dermal matrix",[13,20],"Procedure: Guided bone regeneration with acellular dermal matrix.",[22,28,31],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Dental implant placement","Participants will have a dental implant placed at a toothless site",[9,16],null,{"type":23,"name":11,"description":29,"armGroupLabels":30,"otherNames":27},"Participants will receive guided bone regeneration at a toothless site with bone substitute and a collagen membrane.",[9],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":27},"Guided bone regeneration with acellular dermal matrix.","Participants will receive guided bone regeneration at a toothless site with bone substitute and an acellular dermal matrix.",[16],[36],{"name":37,"affiliation":5,"role":38},"Muhammad Saleh, BDS, MSD","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":27,"email":44},"David Dunbar, DDS","CONTACT","734-763-3346","dgdunbar@umich.edu",{"name":46,"role":42,"phone":43,"phoneExt":27,"email":47},"Alice Ou, RDH, MS","aliceou@umich.edu",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-83.74088,42.27756,{"lat":60,"lon":59},[63],{"name":46,"role":42,"phone":64,"phoneExt":27,"email":47},"(734) 763-3346",{"type":38,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Muhammad Saleh","Clinical Assistant Professor of Dentistry, Department of Periodotnics and Oral Medicine, School of Dentistry","100599265","implant-phenotype-modification-via-gbr-and-adm-100599265",false,"NCT07082244","Implant Phenotype Modification Via GBR and ADM","Phenotype Modification Via Guided Bone Regeneration and Acellular Dermal Matrix Simultaneous to Delayed Implant Placement: A Double Arm Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Subjects with a physical status of systemically healthy or suffering from mild to moderate, but well-controlled disease; American Society of Anesthesiology (ASA) I or II.\n* Subjects must have one edentulous region, with at least 3 months of healing post-extraction, in the esthetic zone of the maxilla or the premolar and canine region of the mandible. This region includes the maxillary premolars, canines, and incisors.\n* Subjects must have a full mouth plaque and bleeding score of less than or equal to 20%, measured at four sites per tooth.\n* The patients should have a thin periodontal phenotype; bucco-lingual ridge thickness greater than 6mm.\n* Seibert class I deficiency (Seibert, 1983)\n* Patients willing to sign the informed consent.\n\nExclusion Criteria:\n\n* Presence of uncontrolled and\u002For untreated periodontal disease.\n* Patients currently smoking cigarettes, cannabis, and electronic cigarettes.\n* Subjects taking medications known to impact bone metabolism or have the capacity to affect wound healing. These drugs include bisphosphonates, corticosteroids, parathyroid hormone, RANKL inhibitors, past exposure to head and neck radiation, chemotherapy within the last 12 months, among others.\n* Subjects with systemic diseases that impact bone metabolism and wound healing. Namely, osteoporosis, osteopenia, hyperparathyroidism, Paget's disease.\n* Allergy to the graft materials.\n* Pregnant subjects or individuals who self-report as attempting to become pregnant.\n* Patient's unwilling to sign the informed consent.","ALL","18 Years",{"count":78,"type":79},40,"ESTIMATED","INTERVENTIONAL",[82],"NA","Single implant sites with bone loss can often be managed by bone grafting alone. The purpose of this study is to determine whether putting a soft tissue graft substitute over the bone graft will provide an increased benefit for improving the health, appearance, and stability of the bone and gums surrounding the implant.",[85],"Horizontal Ridge Deficiency","2026-07-28",{"date":88,"type":89},"2026-07-30","ACTUAL",{"date":91,"type":89},"2025-06-01",{"date":93,"type":79},"2027-09-01",{"name":5,"class":6},1]