[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533410":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":93,"collaborators":25,"id":96,"slug":97,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":25,"eligibilityCriteria":102,"healthyVolunteers":98,"sex":103,"minAge":104,"maxAge":25,"enrollmentInfo":105,"targetDuration":25,"studyType":108,"phases":109,"briefSummary":111,"conditions":112,"keywords":25,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Seoul National University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Individualized strategy","EXPERIMENTAL","Targeting mean arterial pressure and systolic blood pressure of ≥ -20% of their baseline values in each patient during surgery. The baseline values are defined as the average of all measurements between one day before surgery and the morning of the surgery. The target is applied until discharge from the post-anesthesia care unit. If the patient is transported to the intensive care unit after surgery, not the post-anesthesia care unit, then the strategy is applied until the end of surgery.\n\nThe target is applied until discharge from the post-anesthesia care unit. It the patient is transported to the intensive care unit after surgery, not the post-anesthesia care unit, then the strategy is applied until the end of surgery.",[13],"Other: Individualized perioperative blood pressure management strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional strategy","ACTIVE_COMPARATOR","Targeting a mean arterial pressure of 65 mmHg or higher and a systolic blood pressure of 90 mmHg or higher during surgery. The target is applied until discharge from the post-anesthesia care unit. If the patient is transported to the intensive care unit after surgery, not the post-anesthesia care unit, then the strategy is applied until the end of surgery.",[19],"Other: Conventional perioperative blood pressure management strategy",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Individualized perioperative blood pressure management strategy","In this group, perioperative mean arterial pressure and systolic blood pressure are maintained at no less than -20% of the baseline values of each patient.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Conventional perioperative blood pressure management strategy","In this group, perioperative mean arterial pressure and systolic blood pressure are maintained at ≥65 mmHg and ≥90 mmHg, respectively, in all patients.",[15],[31],{"name":32,"affiliation":5,"role":33},"Karam nam, M.D., Ph.D.","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Karam Nam, M.D., Ph.D.","CONTACT","82-2-2072-0643","karamnam@gmail.com",[41,55,66,74,82],{"facility":42,"status":43,"city":44,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Seoul National University Bundang Hospital","RECRUITING","Seongnam","South Korea",{"type":47,"coordinates":48},"Point",[49,50],127.7548,36.4052,{"lat":50,"lon":49},[53],{"name":54,"role":37,"phone":25,"phoneExt":25,"email":25},"Chang-Hoon Koo",{"facility":5,"status":43,"city":56,"state":25,"zip":57,"country":45,"countryCode":25,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Seoul","03080",{"type":47,"coordinates":59},[60,61],126.9784,37.566,{"lat":61,"lon":60},[64],{"name":65,"role":37,"phone":25,"phoneExt":25,"email":25},"Jae-Woo Ju, M.D.",{"facility":67,"status":43,"city":56,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":68,"geoPoint":70,"contacts":71},"Korea University Guro Hospital",{"type":47,"coordinates":69},[60,61],{"lat":61,"lon":60},[72],{"name":73,"role":37,"phone":25,"phoneExt":25,"email":25},"Hye-Bin Kim",{"facility":75,"status":43,"city":56,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"Samsung Medical Center",{"type":47,"coordinates":77},[60,61],{"lat":61,"lon":60},[80],{"name":81,"role":37,"phone":25,"phoneExt":25,"email":25},"Jungchan Park",{"facility":83,"status":43,"city":84,"state":25,"zip":25,"country":45,"countryCode":25,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Ajou University Hospital","Suwon",{"type":47,"coordinates":86},[87,88],127.00889,37.29111,{"lat":88,"lon":87},[91],{"name":92,"role":37,"phone":25,"phoneExt":25,"email":25},"Ha Yeon Kim",{"type":33,"investigatorFullName":94,"investigatorTitle":95,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Karam Nam, MD","Clinical Associate Professor","100533410","individualized-versus-conventional-perioperative-blood-pressure-management-100533410",false,"NCT06225453","Individualized Versus Conventional Perioperative Blood Pressure Management","Effect of Individualized Versus Conventional Blood Pressure Management on Major Adverse Cardiac, Cerebrovascular, and Renal Events After Major Non-cardiac Surgery: Multicenter, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged ≥65 or,\n* those aged ≥45 with a history of coronary artery disease, peripheral vascular disease, transient ischemic attack\u002Fstroke, or congestive heart failure,\n* undergoing non-cardiac surgery under general anesthesia with an anticipated duration of ≥2 hours.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Organ transplantation surgery\n* Brain\u002Fcarotid artery surgery\n* American Society of Anesthesiologists physical status 5 or 6\n* Pregnancy\n* Uncontrolled preoperative hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg)\n* Estimated glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73m2\n* Renal replacement therapy\n* Acute decompensated heart failure\n* Sepsis\n* Shock\n* Use of inotropes\u002Fvasopressor infusion (dopamine, norepinephrine, vasopressin, etc.)","ALL","45 Years",{"count":106,"type":107},1896,"ESTIMATED","INTERVENTIONAL",[110],"NA","Study objective: To compare the effect of different perioperative blood pressure management strategies on major postoperative adverse outcomes \u002F Study design: a multicenter, randomized controlled trial \u002F Participants: 1896 patients undergoing major non-cardiac surgery \u002F Methods: Patients are randomized into two groups, the individualized strategy (maintaining perioperative mean arterial pressure and systolic blood pressure more than -20% of their baseline values) or the conventional strategy (maintaining perioperative mean arterial pressure ≥65 mmHg and systolic blood pressure ≥90 mmHg in all patients). Then, the frequency of major postoperative adverse outcomes occurring within 7 postoperative days or before discharge (whichever occurs first). \u002F Primary outcome: a composite of all-cause death, stroke, myocardial infarction, new or worsening congestive heart failure, unplanned coronary revascularization, and acute kidney injury, occuring within 7 postoperative days or before discharge (whichever occurs first).",[113],"Major Non-cardiac Surgery","2026-07-05",{"date":116,"type":117},"2026-07-07","ACTUAL",{"date":119,"type":117},"2024-01-29",{"date":121,"type":107},"2026-12-31",{"name":5,"class":6},5]