[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652700":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":55,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":79,"overallStatus":90,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Fatih Sultan Mehmet Training and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"standard PEEP",null,"Patients receiving standard mechanical ventilation with a fixed PEEP of 5 cmH₂O throughout the surgical procedure. Ventilation is maintained in volume-controlled mode with tidal volume 6-8 ml\u002Fkg ideal body weight, I\u002FE ratio 1:2, and FiO₂ 0.40. Respiratory rate is adjusted to maintain EtCO₂ between 35-40 mmHg. Anesthesia is maintained with 1.5-2% sevoflurane and remifentanil infusion 0.05-0.5 mcg\u002Fkg\u002Fmin, titrated to BIS 40-60.",[13],"Procedure: Standard PEEP Ventilation",{"label":15,"type":10,"description":16,"interventionNames":17},"Individualized PEEP","Patients receiving individualized PEEP determined by a recruitment maneuver followed by PEEP titration, applied at 10 minutes after Trendelenburg positioning. The individualized PEEP level is maintained throughout the surgery. All other ventilation parameters are identical to the standard PEEP group: volume-controlled mode, tidal volume 6-8 ml\u002Fkg, I\u002FE ratio 1:2, FiO₂ 0.40, EtCO₂ 35-40 mmHg. Anesthesia maintained with 1.5-2% sevoflurane and remifentanil 0.05-0.5 mcg\u002Fkg\u002Fmin, BIS 40-60.",[18],"Procedure: Individualized PEEP Ventilation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Standard PEEP Ventilation","Mechanical ventilation with a fixed positive end-expiratory pressure (PEEP) of 5 cmH₂O applied throughout the surgical procedure. Volume-controlled ventilation mode with tidal volume 6-8 ml\u002Fkg ideal body weight, inspiratory-to-expiratory ratio 1:2, and fraction of inspired oxygen (FiO₂) 0.40. Respiratory rate adjusted to maintain end-tidal CO₂ (EtCO₂) between 35-40 mmHg. No recruitment maneuver is performed.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Individualized PEEP Ventilation","Individualized PEEP determined by a stepwise recruitment maneuver followed by PEEP titration, applied at 10 minutes after Trendelenburg positioning. The optimal PEEP level is identified based on best dynamic lung compliance and maintained for the remainder of surgery. All other ventilation parameters are identical: volume-controlled mode, tidal volume 6-8 ml\u002Fkg, I\u002FE ratio 1:2, FiO₂ 0.40, EtCO₂ 35-40 mmHg.",[15],[30],{"name":31,"affiliation":32,"role":33},"öznur demiroluk, MD","ISTANBUL PROVINCIAL HEALTH DIRECTORATE FATIH SULTAN MEHMET TRAINING AND RESEARCH HOSPITAL","STUDY_CHAIR",[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"sena solmaz, MD","CONTACT","+905428361205","sancaksenax@gmail.com",[41],{"facility":42,"status":10,"city":43,"state":10,"zip":44,"country":45,"countryCode":10,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Istanbul Provincial Health Directorate Fatih Sultan Mehmet Training and Research Hospital","Istanbul","34000","Turkey (Türkiye)",{"type":47,"coordinates":48},"Point",[49,50],28.94966,41.01384,{"lat":50,"lon":49},[53],{"name":54,"role":37,"phone":38,"phoneExt":10,"email":39},"sena sancak, MD",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","sena solmaz","Principal Investigator","100652700","individualized-vs-standard-peep-and-oxygen-reserve-index-in-laparoscopic-hernia-surgery-100652700",false,"NCT07775573","Individualized vs Standard PEEP and Oxygen Reserve Index in Laparoscopic Hernia Surgery","The Effect of Individualized Positive End-Expiratory Pressure Application on Perioperative Oxygenation Assessed by Oxygen Reserve Index Compared to Standard PEEP in Patients Undergoing Laparoscopic Inguinal Hernia Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Aged 18-75 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic unilateral inguinal hernia repair under general anesthesia\n* Body mass index (BMI) \\\u003C 35 kg\u002Fm²\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age below 18 or above 75 years\n* ASA physical status IV-V\n* Emergency surgical procedure\n* Severe chronic or restrictive pulmonary disease\n* Pulmonary hypertension\n* Obstructive sleep apnea syndrome\n* Preoperative peripheral oxygen saturation \\\u003C 94% on room air\n* Respiratory tract infection within the last two weeks\n* Severe cardiac failure (NYHA III-IV)\n* Pregnancy\n* Communication difficulties preventing NRS assessment\n* Surgical complications during the procedure\n* Operation duration exceeding 3 hours\n* Refusal to provide informed consent","ALL","18 Years","75 Years",{"count":70,"type":71},60,"ESTIMATED","OBSERVATIONAL","During laparoscopic surgery under general anesthesia, lung function can be affected by increased abdominal pressure and patient positioning. Positive end-expiratory pressure (PEEP) is a ventilator setting that helps keep the lungs open during surgery. In standard practice, a fixed PEEP level is applied to all patients. An individualized PEEP approach tailors this setting to each patient based on lung recruitment maneuvers.\n\nThis study investigates whether individualized PEEP improves oxygenation compared to standard PEEP in patients undergoing laparoscopic inguinal hernia surgery. Oxygenation will be continuously monitored using the Oxygen Reserve Index (ORI), a non-invasive sensor. Lung aeration will also be assessed before and after surgery using bedside lung ultrasound.",[75,76,77,78],"Atelectasis","Perioperative Oxygenation","Laparoscopic Inguinal Hernia Repair","Mechanical Ventilation",[80,81,82,83,84,85,86,87,88,89],"Positive End-Expiratory Pressure","PEEP titration","Oxygen Reserve Index","ORI","Lung Ultrasound","Recruitment Maneuver","Lung Protective Ventilation","Dynamic Compliance","Pneumoperitoneum","Trendelenburg Position","NOT_YET_RECRUITING","2026-08-18",{"date":93,"type":94},"2026-08-20","ACTUAL",{"date":96,"type":71},"2026-09",{"date":98,"type":71},"2027-10",{"name":5,"class":6},1]