[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646992":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"University of Roma La Sapienza","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Periodontal Regeneration Cohort",null,"This single cohort consists of patients with Stage III-IV periodontitis presenting at least one deep vertical infrabony defect. All patients receive periodontal regenerative surgery according to clinical indications. The cohort will be subsequently stratified into subgroups during data analysis based on the early wound healing assessment at 1 and 2 weeks to evaluate the impact of healing quality on 12-month clinical attachment level (CAL) and radiographic outcomes and to identify patient-related, site-specific, and\u002For technique-related factors associated with optimal early wound healing,",[13],"Procedure: Periodontal Regenerative Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Periodontal Regenerative Therapy","All subjects undergo surgical debridement of the intrabony defect followed by a regenerative approach (biologics with or without bone grafts, or blood clot alone) using papilla preservation techniques (MIST, M-MIST, MPPT, SPPF, or SFA).",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Andrea Pilloni","CONTACT","+39 3356409374","andrea.pilloni@uniroma1.it",[27],{"facility":28,"status":29,"city":30,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology","RECRUITING","Rome","00161","Italy","IT",{"type":35,"coordinates":36},"Point",[37,38],12.51133,41.89193,{"lat":38,"lon":37},[41],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Andrea Pilloni MD DDS MS","Professor","100646992","influence-of-early-wound-healing-on-the-outcomes-of-regenerative-periodontal-surgery-100646992",false,"NCT07683962","Influence of Early Wound Healing on the Outcomes of Regenerative Periodontal Surgery","Influence of Early Wound Healing on the 12-month Clinical and Radiographic Outcomes of Regenerative Periodontal Surgery: a Prospective Observational Cohort Study","EWH_reg","Inclusion Criteria:\n\n* Diagnosis of Stage III or IV Periodontitis.\n* Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth \\[PPD\\] \\>= 6 mm, radiographic depth \\>= 3 mm).\n* Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) \\\u003C 15% at the time of surgery.\n\nExclusion Criteria:\n\n* Systemic: ASA III-VI classification; uncontrolled diabetes; medications causing gingival overgrowth (e.g., nifedipine, cyclosporine, phenytoin); heavy smokers (\\>10 cigarettes\u002Fday); pregnancy or lactation.\n* Local: Third molars; Grade III tooth mobility; inadequate endodontic treatment; teeth undergoing orthodontic treatment; teeth supporting removable or implant-linked fixed prosthetics.","ALL","18 Years",{"count":57,"type":58},100,"ESTIMATED","OBSERVATIONAL","This study investigates whether early post-surgical healing (1-2 weeks) affects the 12-month clinical and radiographic success of periodontal regenerative therapy, and identifies patient-related, site-specific, and technique-related factors associated with optimal early wound healing, in patients with Stage III-IV periodontitis.",[62,63],"Intrabony Periodontal Defect","Wound Healing",[65,66],"periodontal regeneration","early wound healing","2026-07-29",{"date":69,"type":70},"2026-07-31","ACTUAL",{"date":72,"type":58},"2026-07",{"date":74,"type":58},"2027-10-01",{"name":5,"class":6},1]