[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653523":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":42,"studyPopulation":32,"armGroups":43,"interventions":56,"overallOfficials":32,"centralContacts":64,"locations":70,"responsibleParty":94,"collaborators":32,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":32,"eligibilityCriteria":104,"healthyVolunteers":100,"sex":105,"minAge":106,"maxAge":32,"enrollmentInfo":107,"targetDuration":32,"studyType":110,"phases":111,"briefSummary":113,"conditions":114,"keywords":32,"overallStatus":73,"whyStopped":32,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"October 6 University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":32},[9],{"measure":10,"description":11,"timeFrame":12},"Change in Radiographic Bone Fill at the Furcation Site","Radiographic bone fill at the furcation site will be assessed using cone-beam computed tomography (CBCT). The analysis will include measurement of the filled bone volume (FBV) at the furcation area using segmentation.","6 months after treatment",[14,17,20,23,26,29],{"measure":15,"description":16,"timeFrame":12},"Change in Horizontal Clinical Attachment Level","Horizontal clinical attachment level will be assessed using periodontal probing at baseline and 6 months after treatment.",{"measure":18,"description":19,"timeFrame":12},"Change in Vertical Clinical Attachment Level","Vertical clinical attachment levels will be assessed using periodontal probing at baseline and 6 months after treatment.",{"measure":21,"description":22,"timeFrame":12},"Change in Probing Pocket Depth","Probing pocket depth (PPD) will be measured in millimeters from the gingival margin to the base of the periodontal sulcus at six sites per tooth using a UNC-15 periodontal probe. Measurements will be recorded at baseline and 6 months after treatment.",{"measure":24,"description":25,"timeFrame":12},"Change in Gingival Margin Location","The location of the gingival margin will be assessed by measuring the distance from the cemento-enamel junction (CEJ) to the gingival margin. Measurements will be recorded at baseline and 6 months after treatment.",{"measure":27,"description":28,"timeFrame":12},"Change in Plaque Index","Plaque index (PI) will be assessed to evaluate oral hygiene status by measuring dental plaque accumulation in areas adjacent to the gingival margin. Plaque index will be recorded at baseline and 6 months after treatment.",{"measure":30,"description":31,"timeFrame":12},"Change in Bleeding on Probing","Bleeding on probing (BoP) will be assessed by gently inserting a periodontal probe into the gingival sulcus at the base of the interdental papilla and recording the intensity of bleeding after a short delay. BoP will be assessed at baseline and 6 months after treatment.",null,{"allocation":34,"interventionModel":35,"interventionModelDescription":32,"primaryPurpose":36,"observationalModel":32,"timePerspective":32,"maskingInfo":37},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":38,"maskingDescription":32,"whoMasked":39},"DOUBLE",[40,41],"PARTICIPANT","OUTCOMES_ASSESSOR","Periodontitis is a multifactorial inflammatory disease that occurs due to the challenge between the host response and specific periodontal pathogens, leading to a gradual destruction of the periodontal supporting tissues over time.\n\nDifferent regenerative approaches have been proposed including guided tissue regeneration (GTR); bone grafts, bioactive agents such as enamel matrix derivative (EMD) and platelet concentrates.\n\nUsing the minimally invasive nonsurgical technique (MINST) implements magnification with microscope\u002Floupes and delicate instruments, to perform the periodontal debridement with more effective root debridement and less soft tissue trauma. MINST significantly improve the visualization and root decontamination, and at the same time preserve the gingival margin and consequently improve the aesthetic results and tissue stability.",[44,50],{"label":45,"type":46,"description":47,"interventionNames":48},"Positive control group","ACTIVE_COMPARATOR","Patients will receive minimally invasive non-surgical technique (MINST) alone",[49],"Procedure: Minimally invasive non-surgical technique (MINST)",{"label":51,"type":52,"description":53,"interventionNames":54},"Test group","EXPERIMENTAL","Patients will receive minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection",[55],"Procedure: Minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection",[57,61],{"type":58,"name":59,"description":47,"armGroupLabels":60,"otherNames":32},"PROCEDURE","Minimally invasive non-surgical technique (MINST)",[45],{"type":58,"name":62,"description":53,"armGroupLabels":63,"otherNames":32},"Minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection",[51],[65],{"name":66,"role":67,"phone":68,"phoneExt":32,"email":69},"Moustafa A Ahmed, B.D.S","CONTACT","00201098378998","23110295.pg@o6u.edu.eg",[71],{"facility":72,"status":73,"city":74,"state":75,"zip":76,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"October 6 University (Faculty of Dentistry)","RECRUITING","Giza","Giza Governorate","12511","Egypt","EG",{"type":80,"coordinates":81},"Point",[82,83],31.20861,30.00944,{"lat":83,"lon":82},[86,87,90,92],{"name":66,"role":67,"phone":68,"phoneExt":32,"email":69},{"name":88,"role":89,"phone":32,"phoneExt":32,"email":32},"Reham L Aggour, MD","SUB_INVESTIGATOR",{"name":91,"role":89,"phone":32,"phoneExt":32,"email":32},"Shereen F Ahmed, MD",{"name":93,"role":89,"phone":32,"phoneExt":32,"email":32},"Wessam I Shehab, MD",{"type":95,"investigatorFullName":96,"investigatorTitle":97,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Moustafa Awadallah Elaref Ahmed","B.D.S Faculty of Dentistry, October 6 University, Egypt","100653523","injectable-platelet-rich-fibrin-with-minimally-invasive-non-surgical-technique-in-treatment-of-grade-ii-furcation-defects-100653523",false,"NCT07787949","Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Grade II Furcation Defects","Evaluation of Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Grade II Furcation Defects: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients of both genders \\>18 years old, medically free of systemic diseases affecting periodontal regeneration.\n* Diagnosis of stage III, grade B periodontitis (according to the AAP\u002FEFP classification 2018) with the presence of class II furcation defect in either the maxillary (buccal) or mandibular arch (buccal or lingual) as determined by clinical evaluation and confirmed by radiographic evaluation.\n* Gingival margin and interdental bone positioned coronally to the furcation entrance.\n* Commitment to maintenance visits and follow-up.\n* Absence of primary endodontic lesions.\n\nExclusion Criteria:\n\n* Patients suffering from any systemic diseases that may affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc;\n* Patients that received periodontal surgical treatments in the past 12 months.\n* Smoking (current or in past 5 years)\n* Prolonged treatment with antibiotics or anti-inflammatory agents within 6 months prior to periodontal therapy.\n* Pregnant and lactating females.\n* Teeth with hopeless prognosis\n* Third molars","ALL","18 Years",{"count":108,"type":109},30,"ESTIMATED","INTERVENTIONAL",[112],"NA","This study aims to compare the clinical and radiographic effectiveness of injectable platelet-rich fibrin (i-PRF) combined with minimally invasive non-surgical therapy (MINST) versus MINST alone in the management of class II furcation defects.",[115,116,117,118],"Injectable Platelet-Rich Fibrin","Minimally Invasive","Non-Surgical Technique","Grade II Furcation Defects","2026-08-23",{"date":121,"type":122},"2026-08-26","ACTUAL",{"date":124,"type":122},"2026-03-11",{"date":126,"type":109},"2027-03-11",{"name":5,"class":6},1]