[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651474":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":28,"responsibleParty":45,"collaborators":49,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"CLL",null,"Patients diagnosed with CLL",{"label":13,"type":10,"description":14,"interventionNames":10},"SMZL","Patients diagnosed with SMZL",{"label":16,"type":10,"description":17,"interventionNames":10},"HCL","Patients diagnosed with HCL",[19,24],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Cristina Scielzo, PhD","CONTACT","+390226436487","scielzo.cristina@hsr.it",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Lydia Scarfò, MD","+390226436119","scarfo.lydia@hsr.it",[29],{"facility":30,"status":10,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"IRCCS Ospedale San Raffaele","Milan","MI","20132","Italy","IT",{"type":37,"coordinates":38},"Point",[39,40],9.18951,45.46427,{"lat":40,"lon":39},[43,44],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Cristina Scielzo","Head, Malignant B cells biology and 3D modelling Unit",[50],{"name":51,"class":52},"Ministry of Health, Italy","OTHER_GOV","100651474","innovative-3d-preclinical-models-for-mature-b-cell-malignancies-to-advance-personalized-immuno-and-combination-therapies-100651474",false,"NCT07759661","Innovative 3D Preclinical Models for Mature B-cell Malignancies to Advance Personalized Immuno and Combination Therapies","IMPACT","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosis of CLL, SMZL or HCL\n* Participant is willing and able to autonomously give informed consent for participation in the study.\n\nExclusion Criteria:\n\n\\- Participant is unable or unwilling to provide informed consent for participation in the study","ALL","18 Years",{"count":63,"type":64},64,"ESTIMATED","OBSERVATIONAL","Adult patients with chronic lymphocytic leukemia (CLL), splenic marginal-zone lymphoma (SMZL) and hairy cell leukemia (HCL) followed at participating clinical sites will be enrolled and undergo sampling of additional amount of blood during the blood draws performed as part of standard clinical care.\n\nThe project aims to develop and validate innovative patient-derived 3D bioprinted models that faithfully reproduce the key microenvironments of lymphoid tissues, enabling a more physiologically relevant study of mature B-cell malignancies.",[68,69,70],"Chronic Lymphocytic Leukemia (CLL)","Splenic Marginal Zone Lymphoma","Hairy Cell Leukemia (HCL)",[72,73],"B-cell malignancies","3D models","NOT_YET_RECRUITING","2026-08-11",{"date":77,"type":78},"2026-08-13","ACTUAL",{"date":80,"type":64},"2026-11",{"date":82,"type":64},"2029-11",{"name":5,"class":6},1]