[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555295":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":20,"studyPopulation":20,"armGroups":29,"interventions":41,"overallOfficials":46,"centralContacts":50,"locations":56,"responsibleParty":71,"collaborators":74,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":20,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":20,"enrollmentInfo":87,"targetDuration":20,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":20,"overallStatus":59,"whyStopped":20,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Mayo Clinic","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Change in inspiratory muscle blood flow demand","Inspiratory muscle blood flow demand will be measured via indocyanine green dye venous bolus injection. This will be measured in umol.","Baseline, 8 weeks",[14,17],{"measure":15,"description":16,"timeFrame":12},"Change in locomotor muscle blood flow","Locomotor muscle blood flows will be measured via indocyanine green dye venous bolus injection. This will be measured in umol.",{"measure":18,"description":19,"timeFrame":12},"Change in exercise tolerance","Exercise tolerance will be measured via submaximal exercise test. This will be measured in minutes.",null,{"allocation":22,"interventionModel":23,"interventionModelDescription":20,"primaryPurpose":6,"observationalModel":20,"timePerspective":20,"maskingInfo":24},"RANDOMIZED","PARALLEL",{"masking":25,"maskingDescription":20,"whoMasked":26},"DOUBLE",[27,28],"PARTICIPANT","OUTCOMES_ASSESSOR",[30,36],{"label":31,"type":32,"description":33,"interventionNames":34},"Inspiratory muscle training (IMT) group","EXPERIMENTAL","IMT performed at 40% maximal inspiratory pressure (MIP) for 30 minutes 7 days a week for 8 weeks.",[35],"Other: Inspiratory Muscle Training",{"label":37,"type":38,"description":39,"interventionNames":40},"SHAM group","SHAM_COMPARATOR","IMT performed at 2% maximal inspiratory pressure (MIP) for 30 minutes 7 days a week for 8 weeks.",[35],[42],{"type":6,"name":43,"description":44,"armGroupLabels":45,"otherNames":20},"Inspiratory Muscle Training","Inspiratory muscle training (IMT) targets the inspiratory muscles and is used to improve inspiratory muscle strength.",[31,37],[47],{"name":48,"affiliation":5,"role":49},"Joshua Smith, PhD","PRINCIPAL_INVESTIGATOR",[51],{"name":52,"role":53,"phone":54,"phoneExt":20,"email":55},"Eric Bruhn, M.A.","CONTACT","507-266-2690","bruhn.eric@mayo.edu",[57],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":20},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-92.4699,44.02163,{"lat":69,"lon":68},{"type":49,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Joshua R. Smith","Principal Investigator",[75],{"name":76,"class":77},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100555295","inspiratory-muscle-training-in-hfpef-100555295",false,"NCT06510231","Inspiratory Muscle Training in HFpEF","Inspiratory Muscle Training in Heart Failure With Preserved Ejection Fraction","Inclusion Criteria:\n\n* ≥18 yrs of age\n* Receiving SGLT2 inhibitors and spironolactone (and beta-blocker use for HFpEF patients with hypertension) for \\>3 months\n* NYHA symptoms I-III\n* Body mass index ≤40 kg\u002Fm2\n* Currently non-smokers with \\\u003C20 pack year history\n* Able to exercise (i.e. without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise)\n\nExclusion Criteria:\n\n* Sustained ventricular tachycardia and\u002For ventricular fibrillation within 21 days of visit 1\n* Second or third degree heart block\n* Body mass index \\>40 kg\u002Fm2\n* Current smokers and\u002For smoking history \\>20 pack years\n* Pregnant women (testing will be done by research team if requested)\n* Glomerular filtration rate of \\\u003C30 mL\u002Fmin\u002F1.73m2 (initial screen via clinical record within the past 6 months and this will be assessed on Visit 1)\n* Individuals who are not able to engage in exercise\n* Uremia, history of allergy to iodides\n* Peripheral artery disease\n* Alanine transaminase and\u002For aspartate transaminase greater than 2 times the upper limit of normal (via clinical record within the past 6 months)\n* Asthmatic patients with a low symptom perception and suffer frequency, severe exacerbations or with an abnormally low perception of dyspnea\n* Ruptured eardrum or any other condition of the ear\n* History of spontaneous pneumothorax or osteoporosis with a history of rib fractures\n* History of lidocaine allergy.\n\nFor individuals agreeing to undergo dual energy x-ray absorptiometry (DEXA) scanning for measurement of body composition as part of their study visit, additional exclusion criteria apply: recently administered gastrointestinal contrast or radionuclides; severe degenerative changes or fracture deformity in measurement areas; or inability to attain correct position and\u002For remain motionless for the measurement period.","ALL","18 Years",{"count":88,"type":89},68,"ESTIMATED","INTERVENTIONAL",[92],"NA","This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.",[95],"Heart Failure","2026-08-05",{"date":98,"type":99},"2026-08-07","ACTUAL",{"date":101,"type":99},"2024-10-09",{"date":103,"type":89},"2028-04",{"name":5,"class":6},1]