[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648550":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":57,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":26,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":26,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"control","PLACEBO_COMPARATOR","Normal Saline boluses",[13],"Drug: Normal Saline",{"label":15,"type":16,"description":17,"interventionNames":18},"ephedrine","ACTIVE_COMPARATOR","ephedrine boluses",[19],"Drug: Ephedrine",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Normal Saline","four 10-mL syringes of normal saline, The patient will receive the first dose of the intervention with induction (0.1 ml\u002Fkg). After induction of anesthesia, the study drug will be given every 5 min for 20 min and will be withheld if MAP was ≥80 mmHg or if any vasopressor is given within 2 min of the current scheduled dose",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Ephedrine","four 10-mL syringes of ephedrine 1 mg\u002FmL. The patient will receive the first dose of the intervention with induction (0.1 ml\u002Fkg). After induction of anesthesia, the study drug will be given every 5 min for 20 min and will be withheld if MAP was ≥80 mmHg or if any vasopressor is given within 2 min of the current scheduled dose.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Maha Mostafa, MD","CONTACT","+201000365115","maha.mostafa@cu.edu.eg",[38],{"facility":39,"status":40,"city":41,"state":26,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Kasr Alainy Hospital","RECRUITING","Cairo","11562","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.24967,30.06263,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":55,"email":56},"ahmed hasanin","01095076954","+2","ahmedmohamedhasanin@gmail.com",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Ahmed Hasanin","Professor","100648550","intermittent-ephedrine-boluses-for-prophylaxis-against-postinduction-hypotension-100648550",false,"NCT07722013","Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension","Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension in High-risk Patients Undergoing Major Abdominal Surgery: a Randomized Double-blinded Controlled Trial: a Randomized Double-blinded Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged \\>50 years,\n* weight \\>50 kg,\n* American Society of Anesthesiologists (ASA) Physical Status score of \\> I,\n* undergoing major abdominal surgery\n\nExclusion Criteria:\n\n* Severe cardiac morbidities (impaired contractility with ejection fraction \\\u003C 40%, heart block, significant uncontrolled arrhythmias, tight stenotic valvular lesions)\n* Acute cardiovascular pathologies: acute\u002Fdecompensated heart failure, acute coronary syndrome\n* Uncontrolled hypertension (systolic blood pressure\\>150 mmHg)\n* Preoperative HR more than 110 bpm despite proper fluid management and patients with renal impairment\n* Renal impairment\n* Patients on vasopressor infusion,\n* Allergy of any of the study drugs","ALL","50 Years",{"count":71,"type":72},124,"ESTIMATED","INTERVENTIONAL",[75],"NA","The aim of this work is to assess the efficacy of intermittent ephedrine boluses in prophylaxis against postinduction hypotension in high-risk patients undergoing major abdominal surgery, compared to standard care.",[78],"Postinduction Hypotension",[80,81,15,82,83],"major abdominal surgery","high risk patients","prophylaxis","postinduction hypotension","2026-08-04",{"date":86,"type":87},"2026-08-06","ACTUAL",{"date":84,"type":87},{"date":90,"type":72},"2026-12",{"name":5,"class":6},1]