[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555136":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":30,"locations":36,"responsibleParty":322,"collaborators":324,"id":328,"slug":329,"hasResults":330,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":330,"sex":336,"minAge":10,"maxAge":10,"enrollmentInfo":337,"targetDuration":340,"studyType":341,"phases":10,"briefSummary":342,"conditions":343,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":354},{"fullName":5,"class":6},"Population Health Research Institute","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"CRDS",null,"Possesses a rare RYR2 variant characterized to be loss-of-function based on in vitro testing consistent with a CRDS diagnosis",{"label":13,"type":10,"description":14,"interventionNames":10},"Carrier of an RYR2 truncating variant or large copy number variant","Possesses a rare RYR2 truncating variant and\u002For large copy number variant involving the RYR2 gene.",{"label":16,"type":10,"description":17,"interventionNames":10},"Carrier of a non-functional RYR2 rare variant","Possesses a rare RYR2 variant that is NOT loss-of-function based on in vitro testing and has a clinical phenotype that was considered compatible with CRDS",[19,23,27],{"name":20,"affiliation":21,"role":22},"Thomas M Roston, MD, PhD","University of British Columbia","STUDY_CHAIR",{"name":24,"affiliation":25,"role":26},"Jason D Roberts, MD MAS","McMaster University","PRINCIPAL_INVESTIGATOR",{"name":28,"affiliation":29,"role":26},"SR Wayne Chen, PhD","University of Calgary",[31],{"name":24,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","905-297-3479","40632","crds@phri.ca",[37,57,71,85,99,115,131,144,159,173,183,196,209,222,236,248,263,279,294,310],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of California","RECRUITING","San Francisco","California","94143","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-122.41942,37.77493,{"lat":49,"lon":48},[52,55],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},"Project Manager","905-521-2100",{"name":56,"role":26,"phone":10,"phoneExt":10,"email":10},"Vasanth Vedantham, MD, PhD",{"facility":58,"status":39,"city":59,"state":60,"zip":61,"country":43,"countryCode":44,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Mayo Clinic","Rochester","Minnesota","55905",{"type":46,"coordinates":63},[64,65],-92.4699,44.02163,{"lat":65,"lon":64},[68,69],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":70,"role":26,"phone":10,"phoneExt":10,"email":10},"John Giudicessi, MD, PhD",{"facility":72,"status":39,"city":73,"state":74,"zip":75,"country":43,"countryCode":44,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Duke University","Durham","North Carolina","27710",{"type":46,"coordinates":77},[78,79],-78.89862,35.99403,{"lat":79,"lon":78},[82,83],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":84,"role":26,"phone":10,"phoneExt":10,"email":10},"Andrew Landstrom, MD, PhD",{"facility":86,"status":39,"city":87,"state":88,"zip":89,"country":43,"countryCode":44,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Inova Health Care Services","Fairfax","Virginia","22031",{"type":46,"coordinates":91},[92,93],-77.30637,38.84622,{"lat":93,"lon":92},[96,97],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":98,"role":26,"phone":10,"phoneExt":10,"email":10},"Robert Przybylski, MD",{"facility":100,"status":39,"city":101,"state":102,"zip":103,"country":104,"countryCode":105,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Garvan Institute of Medical Research","Darlinghurst","New South Wales","2010","Australia","AU",{"type":46,"coordinates":107},[108,109],151.21925,-33.87939,{"lat":109,"lon":108},[112,113],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":114,"role":26,"phone":10,"phoneExt":10,"email":10},"Jodie Ingles, PhD, MPH",{"facility":116,"status":39,"city":117,"state":118,"zip":119,"country":120,"countryCode":121,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Antwerp University Hospital","Edegem","Antwerp","2650","Belgium","BE",{"type":46,"coordinates":123},[124,125],4.44504,51.15662,{"lat":125,"lon":124},[128,129],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":130,"role":26,"phone":10,"phoneExt":10,"email":10},"Johan Saenen, MD, PhD",{"facility":132,"status":39,"city":133,"state":10,"zip":134,"country":120,"countryCode":121,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Universitair Ziekenhuis Brussel","Brussels","1090",{"type":46,"coordinates":136},[137,138],4.34878,50.85045,{"lat":138,"lon":137},[141,142],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":143,"role":26,"phone":10,"phoneExt":10,"email":10},"Luigi Pannone, MD",{"facility":29,"status":39,"city":145,"state":146,"zip":147,"country":148,"countryCode":149,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Calgary","Alberta","T2N 1N4","Canada","CA",{"type":46,"coordinates":151},[152,153],-114.08529,51.05011,{"lat":153,"lon":152},[156,157],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":158,"role":26,"phone":10,"phoneExt":10,"email":10},"Erkan Ilhan, MD",{"facility":160,"status":39,"city":161,"state":162,"zip":163,"country":148,"countryCode":149,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Children's & Women's Health Centre of British Columbia","Vancouver","British Columbia","V6H 3N1",{"type":46,"coordinates":165},[166,167],-123.11934,49.24966,{"lat":167,"lon":166},[170,171],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":172,"role":26,"phone":10,"phoneExt":10,"email":10},"Shubhayan Sanatani, MD",{"facility":174,"status":39,"city":161,"state":162,"zip":175,"country":148,"countryCode":149,"cosmosGeoPoint":176,"geoPoint":178,"contacts":179},"The University of British Columbia","V6T 1Z3",{"type":46,"coordinates":177},[166,167],{"lat":167,"lon":166},[180,181],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":182,"role":26,"phone":10,"phoneExt":10,"email":10},"Thomas M Roston, MD",{"facility":184,"status":39,"city":185,"state":186,"zip":187,"country":148,"countryCode":149,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"Hamilton General Hospital","Hamilton","Ontario","L8L 2X2",{"type":46,"coordinates":189},[190,191],-79.84963,43.25011,{"lat":191,"lon":190},[194,195],{"name":10,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":24,"role":26,"phone":10,"phoneExt":10,"email":10},{"facility":197,"status":39,"city":198,"state":186,"zip":199,"country":148,"countryCode":149,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"London Health Sciences Centre - University Hospital","London","N6A 5A5",{"type":46,"coordinates":201},[202,203],-81.23304,42.98339,{"lat":203,"lon":202},[206,207],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":208,"role":26,"phone":10,"phoneExt":10,"email":10},"Habib R Khan, MD",{"facility":210,"status":39,"city":211,"state":186,"zip":212,"country":148,"countryCode":149,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"Ottawa Heart Institute","Ottawa","K1Y 4W7",{"type":46,"coordinates":214},[215,216],-75.69812,45.41117,{"lat":216,"lon":215},[219,220],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":221,"role":26,"phone":10,"phoneExt":10,"email":10},"Simon Hansom, MD",{"facility":223,"status":39,"city":224,"state":225,"zip":226,"country":148,"countryCode":149,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"Montréal Heart Institute","Montreal","Quebec","H1T 1C8",{"type":46,"coordinates":228},[229,230],-73.58781,45.50884,{"lat":230,"lon":229},[233,234],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":235,"role":26,"phone":10,"phoneExt":10,"email":10},"Rafik Tadros, MD PhD",{"facility":237,"status":39,"city":238,"state":225,"zip":10,"country":148,"countryCode":149,"cosmosGeoPoint":239,"geoPoint":243,"contacts":244},"Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval","Québec",{"type":46,"coordinates":240},[241,242],-71.21454,46.81228,{"lat":242,"lon":241},[245,246],{"name":10,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":247,"role":26,"phone":10,"phoneExt":10,"email":10},"Christian Steinberg, MD",{"facility":249,"status":39,"city":250,"state":10,"zip":251,"country":252,"countryCode":253,"cosmosGeoPoint":254,"geoPoint":258,"contacts":259},"Aarhus University Hospital","Aarhus","DK-8200 N","Denmark","DK",{"type":46,"coordinates":255},[256,257],10.21076,56.15674,{"lat":257,"lon":256},[260,261],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":262,"role":26,"phone":10,"phoneExt":10,"email":10},"Henrik Jensen, MD",{"facility":264,"status":39,"city":265,"state":266,"zip":267,"country":268,"countryCode":269,"cosmosGeoPoint":270,"geoPoint":274,"contacts":275},"CHU de Bordeaux","Bordeaux","New Aquitaine","33404","France","FR",{"type":46,"coordinates":271},[272,273],-0.58046,44.84124,{"lat":273,"lon":272},[276,277],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":278,"role":26,"phone":10,"phoneExt":10,"email":10},"Frédéric Sacher, MD",{"facility":280,"status":39,"city":281,"state":10,"zip":282,"country":283,"countryCode":284,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"Shaare Zedek Medical Center","Jerusalem","9103102","Israel","IL",{"type":46,"coordinates":286},[287,288],35.21633,31.76904,{"lat":288,"lon":287},[291,292],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":293,"role":26,"phone":10,"phoneExt":10,"email":10},"Ziv Dadon, MD",{"facility":295,"status":39,"city":296,"state":297,"zip":298,"country":299,"countryCode":300,"cosmosGeoPoint":301,"geoPoint":305,"contacts":306},"Oxford University Hospitals","Oxford","Oxfordshire","0X3 9DU","United Kingdom","UK",{"type":46,"coordinates":302},[303,304],-1.25596,51.75222,{"lat":304,"lon":303},[307,308],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":309,"role":26,"phone":10,"phoneExt":10,"email":10},"Julian Ormerod, BM, Bch, FRCP",{"facility":311,"status":39,"city":198,"state":10,"zip":312,"country":299,"countryCode":300,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"City St George's, University of London","EC1V 0HB",{"type":46,"coordinates":314},[315,316],-0.12574,51.50853,{"lat":316,"lon":315},[319,320],{"name":53,"role":32,"phone":54,"phoneExt":10,"email":35},{"name":321,"role":26,"phone":10,"phoneExt":10,"email":10},"Mark Specterman, MBBS, MRCP, PhD",{"type":323,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[325],{"name":326,"class":327},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV","100555136","international-crds-registry-100555136",false,"NCT06508164","International CRDS Registry","International Calcium Release Deficiency Syndrome Registry","CRDS Registry","CRDS Cohort\n\nInclusion Criterion:\n\n\\- Presence of a rare\\* RYR2 variant that is characterized to be loss-of-function based on in vitro testing#\n\nRYR2 Truncating and Large CNV Cohort\n\nInclusion Criterion:\n\n\\- Presence of a rare\\* RYR2 truncating variant and\u002For large copy number variant involving the RYR2 gene.\n\nCarriers of a Non-Functional RYR2 variant\n\nInclusion Criterion:\n\n\\- Presence of a rare\\* RYR2 variant that is characterized to be neither loss- nor gain-of-function based on in vitro testing#\n\n\\*rare defined as gnomAD prevalence \\\u003C 0.1%\n\n#RYR2 in vitro functional testing will be performed in the laboratory of Dr. Wayne Chen (University of Calgary)","ALL",{"count":338,"type":339},500,"ESTIMATED","26 Years","OBSERVATIONAL","Calcium Release Deficiency Syndrome (CRDS) is a newly discovered genetic arrhythmia syndrome that confers a risk of life-threatening arrhythmias secondary to RYR2 loss-of-function. The International CRDS registry has been designed to facilitate large-scale evaluation of CRDS, including its phenotypic spectrum, approaches to risk stratification, and optimal treatment strategies.",[344],"Calcium Release Deficiency Syndrome","2026-07-31",{"date":347,"type":348},"2026-08-04","ACTUAL",{"date":350,"type":348},"2024-11-21",{"date":352,"type":339},"2050-12-31",{"name":5,"class":6},20]