[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648509":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":39,"centralContacts":47,"locations":55,"responsibleParty":82,"collaborators":86,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":92,"sex":98,"minAge":99,"maxAge":34,"enrollmentInfo":100,"targetDuration":34,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":113,"overallStatus":123,"whyStopped":34,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"University Hospital of Cologne","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intrahospital vaccination offer","EXPERIMENTAL","Patients receive standardized active influenza vaccination counseling and are additionally offered bedside intrahospital vaccination against seasonal influenza according to the latest STIKO recommendations at any time prior to discharge during the index hospitalization.",[13,14],"Biological: Intrahospital seasonal influenza vaccination offer","Behavioral: Standardized active influenza vaccination counseling",{"label":16,"type":17,"description":18,"interventionNames":19},"Active counseling alone (standard of care)","ACTIVE_COMPARATOR","Patients receive standardized active influenza vaccination counseling and the current standard of care in Germany, i.e., the recommendation to obtain ambulatory influenza vaccination as stated in the discharge papers. No intrahospital influenza vaccination is administered during the index hospitalization.",[14,20],"Behavioral: Standard of care discharge recommendation for ambulatory vaccination",[22,29,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"BIOLOGICAL","Intrahospital seasonal influenza vaccination offer","Offer of bedside vaccination against seasonal influenza during the index hospitalization, administered in a standardized manner by trained treating physicians according to the latest STIKO recommendations and the respective product information. The appropriate vaccine is selected according to current recommendations (e.g., high-dose quadrivalent vaccine for patients aged 60 years and older, standard-dose quadrivalent vaccine otherwise). Vaccination is offered from September 1 to February 28 of the respective influenza season.",[9],[28],"Seasonal influenza vaccine (high-dose or standard-dose according to STIKO recommendations)",{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"BEHAVIORAL","Standardized active influenza vaccination counseling","Standardized active counseling on influenza vaccination using a cardiovascular gain-framed information sheet, including the recommendation to be vaccinated and the opportunity to discuss vaccination with the treating physician. Counseling is provided to all patients in both arms after completion of the baseline 7C questionnaire and prior to randomization.",[16,9],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Standard of care discharge recommendation for ambulatory vaccination","Current standard of care in Germany: the recommendation to obtain ambulatory influenza vaccination from the primary care physician, stated in the discharge papers.",[16],[40,44],{"name":41,"affiliation":42,"role":43},"Stephan Baldus, Prof. Dr. med.","Clinic III for Internal Medicine, University Hospital of Cologne","PRINCIPAL_INVESTIGATOR",{"name":45,"affiliation":42,"role":46},"Sebastian Heyne, Dr. med.","STUDY_DIRECTOR",[48,52],{"name":45,"role":49,"phone":50,"phoneExt":34,"email":51},"CONTACT","+49 221 478-82019","sebastian.heyne@uk-koeln.de",{"name":41,"role":49,"phone":53,"phoneExt":34,"email":54},"+49 221 478-32511","stephan.baldus@uk-koeln.de",[56,70],{"facility":42,"status":34,"city":57,"state":34,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Cologne","50937","Germany","DE",{"type":62,"coordinates":63},"Point",[64,65],6.95,50.93333,{"lat":65,"lon":64},[68,69],{"name":45,"role":49,"phone":50,"phoneExt":34,"email":51},{"name":41,"role":43,"phone":34,"phoneExt":34,"email":34},{"facility":71,"status":34,"city":72,"state":34,"zip":73,"country":59,"countryCode":60,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Department of Cardiology, University Heart and Vascular Centre Hamburg","Hamburg","20246",{"type":62,"coordinates":75},[76,77],9.99302,53.55073,{"lat":77,"lon":76},[80],{"name":81,"role":43,"phone":34,"phoneExt":34,"email":34},"Natalie Arnold, Dr. med.",{"type":83,"investigatorFullName":84,"investigatorTitle":85,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"SPONSOR_INVESTIGATOR","Stephan Baldus","Principal Investigator, Director of Clinic III for Internal Medicine",[87],{"name":88,"class":89},"Sanofi","INDUSTRY","100648509","intrahospital-influenza-vaccination-in-patients-at-high-cardiovascular-risk-vacc-up-100648509",false,"NCT07721649","Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)","Intrahospital Vaccination and Active Counseling Versus Active Counseling Alone to Increase Seasonal Influenza immUnization in Patients at High Cardiovascular Risk in Germany: The Randomized Controlled VACC-UP Study","VACC-UP","Inclusion Criteria:\n\n* Age 18 years or older\n* Hospitalized due to acute coronary syndrome (ACS) or congestive heart failure (CHF) and fulfilling the criteria for influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO)\n* Written informed consent\n\nExclusion Criteria:\n\n* Already received seasonal influenza vaccination in the current season, based on self-reported vaccination status and\u002For vaccination certificate\n* Laboratory-confirmed active influenza infection during the index hospitalization\n* Contraindication for vaccination (e.g., known allergy)\n* Inability to provide written informed consent","ALL","18 Years",{"count":101,"type":102},482,"ESTIMATED","INTERVENTIONAL",[105],"NA","The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS) or congestive heart failure (CHF), compared with active counseling alone, on influenza vaccination rates in patients at high cardiovascular risk.\n\nPatients are randomized 1:1 to either an offer of bedside intrahospital influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO) in addition to standardized active counseling (intervention group), or standardized active counseling plus the standard-of-care recommendation for ambulatory vaccination in the discharge papers (control group). The primary endpoint is the influenza vaccination rate at the end of the index season (March 31).",[108,109,110,111,112],"Acute Coronary Syndrome","Heart Failure","Influenza, Human","Cardiovascular Diseases","Vaccination Refusal",[114,115,116,117,118,119,120,121,122],"Influenza vaccination","Vaccination rate","Intrahospital vaccination","Acute coronary syndrome","Congestive heart failure","Health services research","Vaccine hesitancy","7C psychological antecedents of vaccination","Cardiovascular prevention","NOT_YET_RECRUITING","2026-07-18",{"date":126,"type":127},"2026-07-23","ACTUAL",{"date":129,"type":102},"2026-09",{"date":131,"type":102},"2029-06",{"name":84,"class":6},2]