[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646370":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":55,"collaborators":39,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":39,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":39,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":43,"whyStopped":39,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Alexandria University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"group 1","EXPERIMENTAL","Bupivacaine 100 mg (20 mL, plain bupivacaine HCl 0.5%) + dexmedetomidine (1 µg\u002Fkg).",[13],"Other: Bupivacaine 100 mg + dexmedetomidine 1 µg\u002Fkg",{"label":15,"type":16,"description":17,"interventionNames":18},"group 2","ACTIVE_COMPARATOR","Bupivacaine 100 mg (20 mL, plain bupivacaine HCl 0.5%) + magnesium sulphate (50 mg\u002Fkg).",[19],"Other: Bupivacaine 100 mg + magnesium sulphate 50 mg\u002Fkg",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Bupivacaine 100 mg + dexmedetomidine 1 µg\u002Fkg","20 ml bupivacaine + 1 µg\u002Fkg dexmedetomidine . The total volume will be adjusted to 50 mL with saline.",[9],[9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Bupivacaine 100 mg + magnesium sulphate 50 mg\u002Fkg","20 ml bupivacaine + 50 mg\u002Fkg magnesium sulphate . The total volume will be adjusted to 50 mL with saline.",[15],[15],[32],{"name":33,"affiliation":5,"role":34},"sarah m elgamal, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","01005496440",null,"sarahelgamal1990@yahoo.com",[42],{"facility":5,"status":43,"city":44,"state":39,"zip":39,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Alexandria","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],29.91582,31.20176,{"lat":51,"lon":50},[54],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},{"type":34,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"sarah mohamed","lecturer","100646370","intraperitoneal-dexmedetomidine-versus-magnesium-as-adjuvants-to-bupivacaine-in-laparoscopic-cholecystectomy-100646370",false,"NCT07693621","Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy","Intraperitoneal Instillation of Dexmedetomidine Versus Magnesium Sulphate as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients aged 18-60 years\n* ASA physical status I-II\n* scheduled for elective laparoscopic cholecystectomy under general anesthesia.\n\nExclusion Criteria:\n\n* Known hypersensitivity to study drugs\n* history of cardiac arrhythmias or conduction abnormalities\n* severe hepatic\u002Frenal impairment\n* chronic opioid or analgesic use\n* pregnancy\n* conversion to open surgery\n* drain insertion.","ALL","18 Years","60 Years",{"count":69,"type":70},80,"ESTIMATED","INTERVENTIONAL",[73],"NA","Although both dexmedetomidine and magnesium sulphate have been individually evaluated as adjuvants to local anesthetics, direct comparisons between the two agents in intraperitoneal instillation during laparoscopic cholecystectomy remain limited. Understanding their relative efficacy and safety could provide valuable guidance for optimizing perioperative analgesia in these patients.",[76,77,78],"Dexmedetomidine","Magnesium Sulfate","Laparoscopic Cholecystectomy",[80,81,82],"bupivacaine","dexmedetomidine","cholecystectomy","2026-07-04",{"date":85,"type":86},"2026-07-09","ACTUAL",{"date":88,"type":86},"2026-05-03",{"date":90,"type":70},"2027-01-01",{"name":5,"class":6},1]