[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652717":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":59,"collaborators":30,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":30,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":30,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":30,"overallStatus":45,"whyStopped":30,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (Morphine group)","EXPERIMENTAL","Patients will receive intrathecal morphine (0,3 mg) in 2 ml normal saline at the end of the operation through a 25G spinal needle through the lumbar intervertebral space (L3-L4 or L4-L5).",[13],"Drug: Intrathecal Morphine",{"label":15,"type":10,"description":16,"interventionNames":17},"Group II (Dexmedetomidine group)","Patients will receive intrathecal dexmedetomidine (8mcg) in 2 ml normal saline at the end of the operation through a 25G spinal needle through the lumbar intervertebral space (L3-L4 or L4-L5).",[18],"Drug: Intrathecal Dexmedetomidine",{"label":20,"type":21,"description":22,"interventionNames":23},"Group III (Placebo group)","PLACEBO_COMPARATOR","Patients will receive intrathecal 2 ml normal saline at the end of the operation through a 25G spinal needle through the lumbar intervertebral space (L3-L4 or L4-L5).",[24],"Drug: Normal Saline",[26,31,34],{"type":27,"name":28,"description":11,"armGroupLabels":29,"otherNames":30},"DRUG","Intrathecal Morphine",[9],null,{"type":27,"name":32,"description":22,"armGroupLabels":33,"otherNames":30},"Intrathecal Dexmedetomidine",[15],{"type":27,"name":35,"description":22,"armGroupLabels":36,"otherNames":30},"Normal Saline",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Abdelhamed I Badreldin, MSc","CONTACT","00201090690631","bedobadr30@gmail.com",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Tanta","El-Gharbia","31527","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.00192,30.78847,{"lat":55,"lon":54},[58],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Abdelhamed Ibrahim Abdelhamed Badreldin","Asisstent Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Egypt","100652717","intrathecal-morphine-versus-intrathecal-dexmedetomidine-compared-to-placebo-for-postoperative-pain-relief-after-spine-fixation-surgeries-100652717",false,"NCT07777627","Intrathecal Morphine Versus Intrathecal Dexmedetomidine Compared to Placebo for Postoperative Pain Relief After Spine Fixation Surgeries","Intrathecal Morphine Versus Intrathecal Dexmedetomidine Compared to Placebo for Postoperative Pain Relief After Spine Fixation Surgeries: A Randomized Double-Blinded Study","Inclusion Criteria:\n\n* Aged between 21 and 60 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) Physical Status I or II.\n* Scheduled for elective lumbar spine fixation surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients' refusal.\n* Decompensated hepatic or renal or cardiac disease.\n* Coagulation disorder.\n* Pregnancy and lactation.\n* Body mass index above 30 kg\u002Fm2.\n* Severe pulmonary disorders.\n* Patients on opioid, alcohol or allergy to any of the study drugs.","ALL","21 Years","60 Years",{"count":74,"type":75},90,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study aims to compare the efficacy of intrathecal morphine and intrathecal dexmedetomidine in reducing pain following lumbar spine fixation surgeries.",[28,32,81,82,83],"Placebo","Postoperative Pain","Spine Fixation Surgeries","2026-08-17",{"date":86,"type":87},"2026-08-20","ACTUAL",{"date":89,"type":87},"2026-07-01",{"date":91,"type":75},"2028-07-01",{"name":5,"class":6},1]