[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654053":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":11,"studyPopulation":11,"armGroups":23,"interventions":35,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":41,"collaborators":11,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":11,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":11,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":71,"whyStopped":11,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":11},{"fullName":5,"class":6},"Lady Reading Hospital, Pakistan","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9,13,15],{"measure":10,"description":11,"timeFrame":12},"heart rate 5minutes after endotracheal intubation",null,"5 minutes after endotracheal intubation",{"measure":14,"description":11,"timeFrame":12},"systolic blood pressure 5 minutes after endo tracheal intubation",{"measure":16,"description":11,"timeFrame":12},"mean arterial pressure 5 minutes after endotracheal intubation",{"allocation":18,"interventionModel":19,"interventionModelDescription":11,"primaryPurpose":20,"observationalModel":11,"timePerspective":11,"maskingInfo":21},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":22,"maskingDescription":11,"whoMasked":11},"NONE",[24,30],{"label":25,"type":26,"description":27,"interventionNames":28},"intravenous Magnesiumm sulphate","EXPERIMENTAL","participants will receive intravenous magnesium Sulphate 30mg\u002Fkg diluted in 100ml normal saline ,administered 90 seconds before induction of general anesthesia",[29],"Drug: Magnesium Sulphate infusion",{"label":31,"type":32,"description":33,"interventionNames":34},"intravenous lignocaine","ACTIVE_COMPARATOR","participants will receive intravenous lignocaine 2mg\u002Fkg ,administered 90 seconds before induction of general anesthesia",[29],[36],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":11},"DRUG","Magnesium Sulphate infusion","intravenous magnesium Sulphate 30mg \u002Fkg diluted in 100ml normal saline, administered 90 sec before induction of general anesthesia",[25,31],{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Syed Muhtaram Shah","Training Medical Officer, Department of Anesthesiology","100654053","intravenous-magnesium-sulphate-versus-lignocaine-for-attenuating-hemodynamic-responses-to-laryngoscopy-and-endotracheal-intubation-100654053",false,"NCT07793955","Intravenous Magnesium Sulphate Versus Lignocaine for Attenuating Hemodynamic Responses to Laryngoscopy and Endotracheal Intubation","Comparison of Intravenous Magnesium Sulphate and Lignocaine in Attenuation of Hemodynamic Responses to Laryngoscopy and Endotracheal Intubation","Inclusion Criteria:\n\n* age 18-70 yrs\n* male and female patients\n* patients undergoing elective or emergency procedures under general anesthesia\n\nExclusion Criteria:\n\n* pregnancy\n* anticipated difficult airway",true,"ALL","18 Years","70 Years",{"count":57,"type":58},78,"ESTIMATED","INTERVENTIONAL",[61],"NA","This study will compare intravenous magnesium sulfate with intravenous lidocaine for reducing the cardiovascular response to endotracheal intubation in adult patients undergoing general anesthesia. Eligible participants will receive either magnesium sulfate or lidocaine before endotracheal intubation. Heart rate and blood pressure will be recorded at predefined time points before and after intubation to compare the effectiveness of the two interventions in attenuating the hemodynamic response to laryngoscopy and endotracheal intubation.",[64],"Hemodynamic Response to Laryngoscopy and Tracheal Intubation",[66,67,68,69,70],"magnesium suplhate","lignocaine","endotracheal intubation","hemodynamic response","laryngoscopy","NOT_YET_RECRUITING","2026-09-02",{"date":74,"type":75},"2026-09-08","ACTUAL",{"date":77,"type":58},"2026-08-20",{"date":79,"type":58},"2026-09-20",{"name":5,"class":6}]