[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659592":3},{"organization":4,"outcomesModule":7,"designInfo":22,"detailedDescription":28,"studyPopulation":21,"armGroups":29,"interventions":40,"overallOfficials":21,"centralContacts":48,"locations":54,"responsibleParty":74,"collaborators":21,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":21,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":105,"whyStopped":21,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"University of British Columbia","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":21,"otherOutcomes":21},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"Isolated mitochondria maximal state 3 respiration (pmols O2\u002Fmicrogram) measured via an ouroborous oxygraph (mitochondrial respirometry)","This measure quantifies the maximal rate of oxygen consumption (picomoles O2\u002F micogram of mitochondrial protein) when ADP, Malate, Succinate, Pyruvate and Glutamate have all been addded to the chamber.","Baseline",{"measure":14,"description":15,"timeFrame":12},"Maximal state 3 respiration in permeabilized Fibers (pmols O2\u002Fmg) measured via an ouroborous oxygraph (mitochondrial respirometry)","This measure quantifies the maximal rate of oxygen consumption (picomoles O2\u002F milligram of muscle tissue) when ADP, Malate, Succinate, Pyruvate and Glutamate have all been added to the chamber.",{"measure":17,"description":18,"timeFrame":12},"Fiber type 1 specific maximal state 3 respiration (pmols O2\u002Fmg) measured via an ouroborous oxygraph (mitochondrial respirometry)","This measure quantifies the maximal rate of oxygen consumption (picomoles O2\u002F micogram of mitochondrial protein) when ADP, Malate, Succinate, Pyruvate and Glutamate have all been added to the chamber.",{"measure":20,"description":11,"timeFrame":12},"Fiber type 2 specific maximal state 3 respiration (pmols O2\u002Fmg) measured via an ouroborous oxygraph (mitochondrial respirometry)",null,{"allocation":23,"interventionModel":24,"interventionModelDescription":25,"primaryPurpose":6,"observationalModel":21,"timePerspective":21,"maskingInfo":26},"NON_RANDOMIZED","PARALLEL","Males and Females will be compared.",{"masking":27,"maskingDescription":21,"whoMasked":21},"NONE","This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35. Participants will complete five laboratory visits over 2-3 weeks, including cycling and single-leg knee extension exercise tests, a dual-energy X-ray absorptiometry (DXA) body composition scan, one resting thigh muscle biopsy, ultrasound blood-flow measurements, muscle oxygen and activity measurements, intramuscular pressure measurement, OMNI perceived exertion ratings, and a finger-prick hemoglobin sample. The study will examine whether sex-related differences in muscle energy use, muscle torque, and muscle pressure help explain blood-flow delivery during exercise.",[30,36],{"label":31,"type":32,"description":33,"interventionNames":34},"Healthy Males","ACTIVE_COMPARATOR","Endurance Trained Healthy Males",[35],"Other: Exercise",{"label":37,"type":32,"description":38,"interventionNames":39},"Healthy Females","Endurance Trained Healthy Females",[35],[41,45],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":21},"Exercise","Exercise - Men",[31],{"type":6,"name":42,"description":46,"armGroupLabels":47,"otherNames":21},"Exercise - Females",[37],[49],{"name":50,"role":51,"phone":52,"phoneExt":21,"email":53},"Lucas Wiens, MSc","CONTACT","1+778-837-7665","wiensl55@student.ubc.ca",[55],{"facility":56,"status":21,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Gateway Health Building","Vancouver","British Columbia","V6T 1Z1","Canada","CA",{"type":63,"coordinates":64},"Point",[65,66],-123.11934,49.24966,{"lat":66,"lon":65},[69,71],{"name":50,"role":51,"phone":52,"phoneExt":21,"email":70},"Wiensl55@student.ubc.ca",{"name":72,"role":73,"phone":21,"phoneExt":21,"email":21},"Robert Boushel, PhD","PRINCIPAL_INVESTIGATOR",{"type":73,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Robert Boushel","Dr. Robert Boushel","100659592","investigating-sex-differences-in-mitochondrial-function-and-leg-blood-flow-during-exercise-100659592",false,"NCT07866651","Investigating Sex Differences in Mitochondrial Function and Leg Blood Flow During Exercise","MITOP","Inclusion Criteria:\n\n* can understand and communicate in English;\n* are 19 to 35 years old;\n* answer \"No\" to all questions on the Canadian Society for Exercise Physiology Get Active Questionnaire (CSEP-GAQ), or have approval from a doctor to do maximal exercise testing;\n* are healthy enough to do hard exercise;\n* are an endurance athlete; and\n* have done at least 6 hours per week of planned endurance training, such as running, cycling, swimming, or rowing, over the past 12 months.\n\nExclusion Criteria:\n\n* • currently use cigarettes, vaping products, or other nicotine products, or have used them in the past 2 years;\n\n  * have a major uncontrolled heart, blood vessel, muscle, metabolic, or nervous system condition\n  * have a medical condition that makes maximal exercise unsafe for you\n  * have heart or lung disease, or a condition that affects your heart, lungs, blood vessels, or muscles\n  * have type 1 or type 2 diabetes\n  * have cancer or have had cancer treatment in the past 12 months\n  * take blood-thinning medicine or have a bleeding disorder\n  * are allergic to lidocaine or other local freezing medicine\n  * are pregnant, think you may be pregnant, or are trying to become pregnant\n  * are unable to follow the study instructions safely",true,"ALL","19 Years","35 Years",{"count":89,"type":90},24,"ESTIMATED","INTERVENTIONAL",[93],"NA","This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35.",[96,97],"Healthy Adult Male","Healthy Adult Females",[99,100,101,102,103,104],"mitochondrial function","intramuscular pressure","VO2max regulation","Sex Differences","muscle torque","Muscle Physiology","NOT_YET_RECRUITING","2026-10-05",{"date":108,"type":109},"2026-10-08","ACTUAL",{"date":111,"type":90},"2026-10-02",{"date":113,"type":90},"2027-05",{"name":5,"class":6},1]