[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646521":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":36,"responsibleParty":52,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":25,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":83,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Personalized optimal gamma auditory frequency stimulation","EXPERIMENTAL","The patient receives personalized optimal gamma auditory frequency stimulation at home for 1 month, 5 days per week, and 1 hour per day. The stimulation frequency is selected based on the frequency that produces the strongest neural entrainment.",[13],"Device: Personalized optimal gamma auditory frequency stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-optimal gamma auditory frequency stimulation","ACTIVE_COMPARATOR","The patient receives non-optimal gamma auditory frequency stimulation at home for 1 month, 5 days per week, and 1 hour per day. The stimulation frequency is selected based on the frequency that produces the weakest neural entrainment.",[19],"Device: Non-optimal gamma auditory frequency stimulation",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Participants will receive personalized optimal gamma auditory frequency stimulation using our app downloaded in the mobile device to play the sound for 1 hour per day, 5 days a week, over 1 month.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants will receive non-optimal gamma auditory frequency stimulation using our app downloaded in the mobile device to play the sound for 1 hour per day, 5 days a week, over 1 month.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Chia-Hsiung Cheng, Ph.D.","CONTACT","+886-3-211800","3854","ch.cheng@mail.cgu.edu.tw",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Chang Gung University","Taoyuan","Guishan","33302","Taiwan","TW",{"type":45,"coordinates":46},"Point",[47,48],121.29696,24.99368,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},{"type":53,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100646521","investigating-the-effectiveness-of-personalized-optimal-gamma-auditory-frequency-stimulation-intervention-on-cognitive-function-enhancement-100646521",false,"NCT07690865","Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement","Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement: An Intervention Study","Inclusion Criteria:\n\n1. Age between 18 to 40 years old.\n2. The Cognitive Abilities Screening Instrument (CASI) score is within normal ranges adjusted for age and education.\n3. Participants have no history of severe neurological or psychiatric disorders (such as stroke, epilepsy, depression, migraine, etc.) that could affect cognitive function.\n4. Participants have not used drugs that may affect cognitive function (e.g., benzodiazepines, anticholinergic medications, etc.).\n5. Participants with normal or corrected vision (e.g., glasses or contact lenses) to normal levels.\n6. Auditory stimuli induce significant neural entrainment.\n7. Self-reported normal hearing\n\nExclusion Criteria:\n\n1. Participants enrolled in any cognitive enhancement study within the past two months.\n2. Participants with a history of disease that could affect cognitive function (e.g., cancer, autoimmune diseases, etc.).\n3. Individuals with tinnitus or hyperacusis",true,"ALL","18 Years","40 Years",{"count":66,"type":67},20,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study aims to evaluate whether personalized gamma-frequency auditory stimulation enhances cognitive function and brain synchronization. While 40 Hz auditory stimulation has been widely studied, recent evidence suggests optimal frequencies vary by individual. Using a cross-over design with 20 healthy adults, the research compares \"optimal\" versus \"non-optimal\" frequencies over one-month intervention periods. Effectiveness is measured through EEG recordings and executive function tasks. The goal is to determine if personalized sensory intervention provides a more effective, non-invasive strategy for enhancing cognitive performance.",[73,74,75,76],"Gamma Oscillations","Healthy Adults","Alzheimer's Disease (AD)","Gamma Entrainment Using Sensory Stimuli (GENUS)",[78,79,80,81,82],"Gamma stimulation","Alzheimer's disease","EEG","cognitive function","intervention","NOT_YET_RECRUITING","2026-07-15",{"date":86,"type":87},"2026-07-16","ACTUAL",{"date":89,"type":67},"2026-08",{"date":91,"type":67},"2027-12",{"name":5,"class":6},1]