[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650671":3},{"organization":4,"armGroups":7,"interventions":51,"overallOfficials":70,"centralContacts":78,"locations":84,"responsibleParty":102,"collaborators":105,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":116,"sex":117,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":57,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":86,"whyStopped":57,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"Wuerzburg University Hospital","OTHER",[8,16,19,22,25,28,31,36,39,42,45,48],{"label":9,"type":10,"description":11,"interventionNames":12},"Striatal tTIS -> Hippocampal tTIS -> Striatal high-frequency control","EXPERIMENTAL","Striatal tTIS and hippocampal tTIS are active experimental conditions. High-frequency control is a placebo comparator. \"Striatal\" in \"striatal high-frequency control\" refers to the electrode set-up (no actual stimulation of the striatum occurs in that condition).",[13,14,15],"Device: Hippocampal intermittent-theta burst stimulation","Device: Striatal intermittent-theta burst stimulation","Device: High-frequency control stimulation with striatal electrode set-up",{"label":17,"type":10,"description":11,"interventionNames":18},"Striatal tTIS -> Striatal high-frequency control -> Hippocampal tTIS",[13,14,15],{"label":20,"type":10,"description":11,"interventionNames":21},"Hippocampal tTIS -> Striatal high-frequency control -> Striatal tTIS",[13,14,15],{"label":23,"type":10,"description":11,"interventionNames":24},"Hippocampal tTIS -> Striatal tTIS -> Striatal high-frequency control",[13,14,15],{"label":26,"type":10,"description":11,"interventionNames":27},"Striatal high-frequency control -> Striatal tTIS -> Hippocampal tTIS",[13,14,15],{"label":29,"type":10,"description":11,"interventionNames":30},"Striatal high-frequency control -> Hippocampal tTIS -> Striatal tTIS",[13,14,15],{"label":32,"type":10,"description":33,"interventionNames":34},"Striatal tTIS -> Hippocampal tTIS -> Hippocampal high-frequency control","Striatal tTIS and hippocampal tTIS are active experimental conditions. High-frequency control is a placebo comparator. \"Hippocampal\" in \"hippocampal high-frequency control\" refers to the electrode set-up (no actual stimulation of the hippocampus occurs in that condition).",[13,14,35],"Device: High-frequency control stimulation with hippocampal electrode set-up",{"label":37,"type":10,"description":33,"interventionNames":38},"Striatal tTIS -> Hippocampal high-frequency control -> Hippocampal tTIS",[13,14,35],{"label":40,"type":10,"description":33,"interventionNames":41},"Hippocampal tTIS -> Hippocampal high-frequency control -> Striatal tTIS",[13,14,35],{"label":43,"type":10,"description":33,"interventionNames":44},"Hippocampal tTIS -> Striatal tTIS -> Hippocampal high-frequency control",[13,14,35],{"label":46,"type":10,"description":33,"interventionNames":47},"Hippocampal high-frequency control -> Striatal tTIS -> Hippocampal tTIS",[13,14,35],{"label":49,"type":10,"description":33,"interventionNames":50},"Hippocampal high-frequency control -> Hippocampal tTIS -> Striatal tTIS",[13,14,35],[52,58,62,66],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":57},"DEVICE","Hippocampal intermittent-theta burst stimulation","Transcranial temporal interference stimulation using intermittent theta-burst protocol and targeting right hippocampus. Unlike the striatal set-up, the hippocampal electrode set-up is asymmetrical and can only stimulate unilaterally (Beanato, Moon et al., 2024; Violante et al., 2023). In the present study, \\*right\\* hippocampus is targeted because it showed cognitive map-compatible activity in a similar task in a previous study (Garvert et al., 2023) and because it has been suggested to be involved in map-based navigation (Iglói et al., 2010).",[49,46,40,20,43,23,29,26,37,32,9,17],null,{"type":53,"name":59,"description":60,"armGroupLabels":61,"otherNames":57},"Striatal intermittent-theta burst stimulation","Transcranial temporal interference stimulation using intermittent theta-burst protocol and targeting bilateral striatum.",[49,46,40,20,43,23,29,26,37,32,9,17],{"type":53,"name":63,"description":64,"armGroupLabels":65,"otherNames":57},"High-frequency control stimulation with striatal electrode set-up","Analoguous to transcranial temporal interference stimulation except both high-frequency electric fields are oscillating at the exact same frequency, meaning there is no biologically active envelope modulation. This high-frequency stimulation is applied with the striatal electrode set-up in 50 % of the subjects (hippocampal set-up in the other 50 %). No stimulation actually occurs because the stimulation frequency is too high to be biologically active (Grossman et al., 2017).",[20,23,29,26,9,17],{"type":53,"name":67,"description":68,"armGroupLabels":69,"otherNames":57},"High-frequency control stimulation with hippocampal electrode set-up","Analoguous to transcranial temporal interference stimulation except both high-frequency electric fields are oscillating at the exact same frequency, meaning there is no biologically active envelope modulation. This high-frequency stimulation is applied with the hippocampal electrode set-up in 50 % of the subjects (striatal set-up in the other 50 %). No stimulation actually occurs because the stimulation frequency is too high to be biologically active (Grossman et al., 2017).",[49,46,40,43,37,32],[71,75],{"name":72,"affiliation":73,"role":74},"Maximilian J. Wessel, Prof. Dr.","University Hospital Würzburg (UKW)","PRINCIPAL_INVESTIGATOR",{"name":76,"affiliation":77,"role":74},"Mona M. Garvert, Prof. Dr.","Julius-Maximilians-Universität Würzburg (JMU)",[79],{"name":80,"role":81,"phone":82,"phoneExt":57,"email":83},"Jana S. Ludwig, M. Sc.","CONTACT","0049 931 3183395","ludwig_j5@ukw.de",[85],{"facility":73,"status":86,"city":87,"state":88,"zip":89,"country":90,"countryCode":91,"cosmosGeoPoint":92,"geoPoint":97,"contacts":98},"RECRUITING","Würzburg","Bavaria","97080","Germany","DE",{"type":93,"coordinates":94},"Point",[95,96],9.95121,49.79391,{"lat":96,"lon":95},[99,100,101],{"name":80,"role":81,"phone":82,"phoneExt":57,"email":83},{"name":72,"role":74,"phone":57,"phoneExt":57,"email":57},{"name":76,"role":74,"phone":57,"phoneExt":57,"email":57},{"type":74,"investigatorFullName":103,"investigatorTitle":104,"investigatorAffiliation":5,"oldNameTitle":57,"oldOrganization":57},"Maximilian Jonas Wessel","Prof. Dr.",[106],{"name":107,"class":6},"University of Wuerzburg","100650671","investigating-the-mechanisms-of-decision-making-using-non-invasive-brain-stimulation-100650671",false,"NCT07749378","Investigating the Mechanisms of Decision-Making Using Non-Invasive Brain Stimulation","Investigating the Interplay of Striatal and Hippocampal Processing in Decision-Making Using Transcranial Temporal Interference Stimulation","StimMaps_YH","Inclusion Criteria:\n\n* No diagnosis of any neurological or psychiatric disease\n\nExclusion Criteria:\n\n* Severe neuropsychiatric or unstable systemic disease\n* Severe sensory or cognitive impairment or musculoskeletal dysfunction that would prevent subjects from understanding the task instructions or executing the tasks\n* Implanted medical devices\n* Diagnosis of epilepsy or history of one or more epileptic seizure(s)\n* Pieces of metal in\u002Faround the head\n* Regular consumption of narcotics (also excluded: cannabis within past month, alcohol abuse or dependence)\n* Pregnancy and breast feeding\n* Incapability of giving informed consent\n* Left-handedness\n\nSubjects included in the study will be excluded from analyses if their datasets are incomplete. To ensure full counterbalancing, excluded subjects will be replaced by new ones.",true,"ALL","18 Years","40 Years",{"count":121,"type":122},36,"ESTIMATED","INTERVENTIONAL",[125],"NA","This study aims to investigate which of two brain regions is important for which decision-making strategy. The investigators suppose that one brain region - the \\*striatum\\* - is important for repeatedly choosing objects that have previously been paired with rewards (strategy 1). They suppose that a different region - the \\*hippocampus\\* - is important for extending such reasoning to RELATED objects (strategy 2).\n\nThe investigators will repeatedly ask young and healthy subjects to choose between two objects. The two objects are repeatedly drawn from a pool of seven. Relations between the seven objects have been learned on the first day of the experiment. The investigators will record subjects' choices and will use an automated way to assess the extent to which any given subject uses either decision-making strategy.\n\n* On one day, subjects will perform the task while their right hippocampus is being stimulated with non-invasive electrical stimulation (\"condition A\").\n* On another day, subjects will perform the same task but with their striatum being stimulated (\"condition B\").\n* On yet another day, a control stimulation (\"condition C\") will be applied that looks and feels like the real stimulation but does not influence brain activity.\n\nWhich stimulation (A, B, C) happens on which day is assigned by computer code and differs between subjects. Subjects do not know, and investigators mostly do not know, whether real or control stimulation is applied on each day.\n\nThe investigators will check whether subjects use strategy 1 more when their striatum is being stimulated and strategy 2 more when their hippocampus is being stimulated, as compared to when the control stimulation is applied.",[128],"Young Healthy Adults",[130,131,132,133,134,135],"Cognitive maps","Model-based vs. model-free decision-making","Reinforcement learning","Computational modeling","Transcranial electric stimulation","Transcranial temporal interference stimulation","2026-08-02",{"date":138,"type":139},"2026-08-06","ACTUAL",{"date":141,"type":139},"2026-04-27",{"date":143,"type":122},"2027-04",{"name":5,"class":6},1]