[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657851":3},{"organization":4,"outcomesModule":7,"designInfo":13,"detailedDescription":11,"studyPopulation":11,"armGroups":19,"interventions":30,"overallOfficials":11,"centralContacts":37,"locations":43,"responsibleParty":60,"collaborators":11,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":11,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":11,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":87,"overallStatus":45,"whyStopped":11,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Connecticut","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Change in serum concentration of large HDL particles between diet periods",null,"4 weeks",{"allocation":14,"interventionModel":15,"interventionModelDescription":11,"primaryPurpose":16,"observationalModel":11,"timePerspective":11,"maskingInfo":17},"RANDOMIZED","CROSSOVER","BASIC_SCIENCE",{"masking":18,"maskingDescription":11,"whoMasked":11},"NONE",[20,25],{"label":21,"type":22,"description":11,"interventionNames":23},"Egg whites","ACTIVE_COMPARATOR",[24],"Other: Egg whites",{"label":26,"type":27,"description":11,"interventionNames":28},"Whole eggs","EXPERIMENTAL",[29],"Other: Whole eggs",[31,34],{"type":6,"name":21,"description":32,"armGroupLabels":33,"otherNames":11},"3 large egg equivalent of liquid egg whites per day for 4 weeks",[21],{"type":6,"name":26,"description":35,"armGroupLabels":36,"otherNames":11},"3 large whole eggs per day for 4 weeks",[26],[38],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},"Catherine J Andersen, PhD, RDN","CONTACT","860-486-1704","catherine.andersen@uconn.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Storrs","Connecticut","06269","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-72.24952,41.80843,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":41,"phoneExt":11,"email":42},"Catherine J. Andersen, PhD, RDN",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Catherine Andersen","Principal Investigator","100657851","investigation-of-egg-intake-and-the-relationship-between-gut-microbiome-metabolic-and-immune-profiles-100657851",false,"NCT07844616","Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles","Inclusion Criteria:\n\n* 18-50 years old (at time of screening)\n* Premenopausal status for women\n* Body mass index (BMI) 18.5 to \\\u003C 25 kg\u002Fm2; or ³ 30 kg\u002Fm2 and \\>30% and \\>40% body fat for men and women, respectively\n* Willing to consume whole eggs and egg whites provided during the study on a daily basis, and refrain from other eggs or egg-based foods and beverages during the study\n* Do not fit any exclusion criteria\n\nExclusion Criteria:\n\n* \\\u003C18 years old and ≥ 51 years old\n* BMI \\\u003C18.5, 25-29.9, or body weight \\\u003C 110 pounds\n* Experienced \\>10% weight change in the past 4 weeks\n* Elevated fasting glucose levels (fasting glucose higher than 126 mg\u002FdL) and triglycerides greater than 500 mg\u002FdL, or total cholesterol \\\u003C 120 mg\u002FdL and HDL- cholesterol \\\u003C 15 mg\u002FdL\n* Self-reported and\u002For physician-diagnosed history of severe constipation, diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and\u002For relapsing\u002Fremitting autoimmune, inflammatory, intestinal or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation, postmenopausal\n* Allergy to eggs\n* Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedence\n* Currently taking lipid-lowering medications (e.g., statins, fibrates), glucose-regulating medications, anti-inflammatory medications (e.g., NSAIDs, corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin), long-term antibiotics or probiotics in the last 3 months or during the intervention\n* Active smoker",true,"ALL","18 Years","50 Years",{"count":75,"type":76},78,"ESTIMATED","INTERVENTIONAL",[79],"NA","The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in normal and obesity ranges. This study further aims to determine whether egg effects are associated with baseline gut microbiome profiles, and whether egg effects are different between males and females and by BMI status. The study will address the following objectives:\n\nObjective 1: Evaluate the effects of daily egg white vs. whole egg intake on gut health, microbiome, and metabolome profiles.\n\nObjective 2: Evaluate the effects of daily egg white vs. whole egg intake on HDL composition and function.\n\nObjective 3: Evaluate the effects of daily egg white vs. whole egg intake on immune profiles and function in culture (ex vivo).\n\nParticipants will be asked to consume egg whites and whole eggs on a daily basis for 4-weeks each, and avoid eating eggs for a total of 8 weeks at different points in the study. Participants will be asked to complete surveys about dietary intake and physical activity, as well as provide blood and stool samples throughout the course of the study.",[82,83,84,85,86],"Obesity (BMI Equal to or >30)","Immune Function","HDL","Gut Microbiome","Healthy Adult Participants",[88,84,89,90,91,92,93],"Eggs","Obesity","Diet intervention","Nutrition","Gut microbioome","Immune function","2026-09-22",{"date":96,"type":97},"2026-09-28","ACTUAL",{"date":99,"type":76},"2026-09",{"date":101,"type":76},"2027-12-31",{"name":5,"class":6},1]