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Prior imatinib is allowed in adjuvant or neoadjuvant setting, as long as imatinib was stopped over 1 year ago.\n* Adequate organ function and performance status\n\nExclusion Criteria\n\nParticipants are excluded from the study if any of the following criteria apply:\n\n* Unable to swallow or GI condition that prevents absorption.\n* Other active malignancies within the last 2 years.\n* History of hypersensitivity to any component of KQB198 or imatinib.","ALL","18 Years",{"count":216,"type":217},46,"ESTIMATED","INTERVENTIONAL",[220],"PHASE2","This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at treating GIST. Imatinib has been approved by the FDA for the treatment of different types of cancer including GIST.",[223,224,225,226,227],"GIST - Gastrointestinal Stromal Tumor","GIST","GIST Metastatic Cancer","Gastro Intestinal Stromal Tumour","Gastrointestinal Tumors",[18,229,230,231,232,233,234,235,236,237,238,239,240],"imatinib","gleevec","gist","gastrointestinal stromal tumor","gastro intestinal stromal tumor","gist first line","gist 1st line","KQB198-103","SynerGIST","SynerGIST-1","SynerGIST-1st","SynerGIST-1st Line","2026-08-05",{"date":243,"type":244},"2026-08-10","ACTUAL",{"date":246,"type":244},"2026-06-23",{"date":248,"type":217},"2028-10",{"name":5,"class":6},17]