[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100656231":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":17,"studyPopulation":17,"armGroups":24,"interventions":37,"overallOfficials":17,"centralContacts":17,"locations":17,"responsibleParty":46,"collaborators":17,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":17,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":17,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":17,"overallStatus":71,"whyStopped":17,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":17},{"fullName":5,"class":6},"University of Health Sciences Lahore","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":17},[9,13],{"measure":10,"description":11,"timeFrame":12},"Incidence of Surgical Site Infection (SSI)","Proportion of patients who develop a surgical site infection, defined as either superficial\u002Fdeep wound infection (presence of purulent discharge, erythema, localized swelling, or requiring reopening) or intra-abdominal abscess (confirmed via ultrasound in patients presenting with abdominal pain, fever, or fullness)","Up to 30 days postoperatively",{"measure":14,"description":15,"timeFrame":16},"Length of Hospital Stay","The total number of days the patient remained in the hospital postoperatively until meeting discharge criteria (afebrile, tolerating a regular diet, and achieving good pain control).","From day of surgery up to discharge (up to 30 days postoperatively)",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":23,"maskingDescription":17,"whoMasked":17},"NONE",[25,31],{"label":26,"type":27,"description":28,"interventionNames":29},"Open Appendectomy","ACTIVE_COMPARATOR","Participants undergo open appendectomy using a standard grid-iron incision under general anesthesia. Appendiceal base ligation and closure are performed in standard anatomical layers.",[30],"Procedure: Open Appendectomy",{"label":32,"type":33,"description":34,"interventionNames":35},"Group 2: Laparoscopic Appendectomy","EXPERIMENTAL","Participants undergo laparoscopic appendectomy using a standard 3-port technique (umbilical, left iliac fossa, and lower midline ports) under general anesthesia.",[36],"Procedure: Laparoscopic Appendectomy",[38,42],{"type":39,"name":26,"description":40,"armGroupLabels":41,"otherNames":17},"PROCEDURE","Open surgical removal of the appendix performed via a standard grid-iron incision under general anesthesia with standard prophylactic antibiotics.",[26],{"type":39,"name":43,"description":44,"armGroupLabels":45,"otherNames":17},"Laparoscopic Appendectomy","Laparoscopic surgical removal of the appendix using a standard 3-port configuration (umbilical, left iliac fossa, and lower midline ports) under general anesthesia with standard prophylactic antibiotics.",[32],{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Saira Khan","Principle Investigator","100656231","laparoscopic-vs-open-appendectomy-in-obese-patients-100656231",false,"NCT07822503","Laparoscopic vs Open Appendectomy in Obese Patients","Evaluation of Post Operative Outcomes of Laparoscopic and Open Appendectomy in Obese Patients","Inclusion Criteria:\n\n1. Obese patients with Body Mass Index (BMI) ≥ 30 kg\u002Fm².\n2. Clinical diagnosis of acute appendicitis based on Alvarado score (history of right lower quadrant or periumbilical pain shifting to RLQ, nausea and\u002For vomiting, fever \\> 38 °C, RLQ guarding and tenderness, and\u002For leukocytosis \\> 10,000 cells\u002FmL).\n3. Age between 15 and 50 years.\n4. Both male and female patients.\n\nExclusion Criteria:\n\n1. Immunocompromised patients (e.g., HIV infection or current steroid therapy).\n2. History of prior chemotherapy, radiotherapy, or recurrent infections.\n3. History of drug or alcohol abuse.\n4. Severe hepatic, renal, or cardiovascular dysfunction.\n5. History of previous abdominal surgery.\n6. Appendicular malignancy.\n7. Pregnant women.\n8. Preoperative findings indicating appendiceal perforation.","ALL","15 Years","50 Years",{"count":61,"type":62},166,"ESTIMATED","INTERVENTIONAL",[65],"NA","Acute appendicitis is one of the most common surgical emergencies globally. While surgical removal of the appendix (appendectomy) is the definitive treatment, the optimal surgical approach-laparoscopic versus open-remains widely debated, particularly in obese patients. Obese individuals present unique surgical challenges due to increased abdominal wall thickness, which often necessitates larger skin incisions during open procedures, potentially increasing postoperative pain, wound healing times, and wound complications.\n\nThis study aims to compare the postoperative outcomes of laparoscopic appendectomy versus standard open appendectomy in obese patients (BMI ≥ 30 kg\u002Fm²) presenting with acute appendicitis. Participants will be randomly assigned to undergo either open appendectomy or laparoscopic appendectomy. The primary outcomes evaluated will be the incidence of surgical site infections (including superficial wound infections and intra-abdominal abscesses) up to 30 days post-procedure and the total length of hospital stay (in days).",[68,69,70],"Acute Appendicitis","Appendicitis (Diagnosis)","Obesity","NOT_YET_RECRUITING","2026-09-10",{"date":74,"type":75},"2026-09-16","ACTUAL",{"date":77,"type":62},"2026-10-02",{"date":79,"type":62},"2027-04-30",{"name":5,"class":6}]