[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655022":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":17,"studyPopulation":17,"armGroups":26,"interventions":39,"overallOfficials":53,"centralContacts":62,"locations":71,"responsibleParty":90,"collaborators":17,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":101,"sex":102,"minAge":17,"maxAge":17,"enrollmentInfo":103,"targetDuration":17,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":120,"whyStopped":17,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},{"fullName":5,"class":6},"University of Bari Aldo Moro","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Periodontal probing depth","Will be measured with dental prob the probing depth before 3 month of the surgery","3 month",[14],{"measure":15,"description":16,"timeFrame":12},"Bleeding on probing","The % os BoP will be value after 3 months.",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":23,"maskingDescription":17,"whoMasked":24},"SINGLE",[25],"PARTICIPANT",[27,33],{"label":28,"type":29,"description":30,"interventionNames":31},"Mechanical Open Flap debridement","ACTIVE_COMPARATOR","Patients with periodontal defects ( more than 5 mm probing after step I and II). Intervention: Following flap elevation, the defects will be instrumented using manual and ultrasonic instruments.",[32],"Procedure: Mechanical Open Flap debridement",{"label":34,"type":35,"description":36,"interventionNames":37},"Laser assisted open Flap debridement","EXPERIMENTAL","The defects will be instrumented using manual and ultrasonic instruments follow by laser debridement and decontamination of the pockets.",[38],"Procedure: Laser assisted open flap debridement",[40,47],{"type":41,"name":28,"description":42,"armGroupLabels":43,"otherNames":44},"PROCEDURE","Open-flap debridement will be performed under local anesthesia. Following incisions, a full-thickness mucoperiosteal flap will be elevated to provide adequate access to the periodontal defect and root surfaces. Granulation tissue will be carefully removed, and thorough root surface debridement will be performed using manual and ultrasonic devices. After instrumentation surgical site, the flap will be repositioned and stabilized with sutures to achieve appropriate wound closure.",[28],[45,46],"Periodontal flap surgery","Access flap surgery",{"type":41,"name":48,"description":49,"armGroupLabels":50,"otherNames":51},"Laser assisted open flap debridement","Open-flap debridement will be performed under local anesthesia. Following intrasulcular incisions, a full-thickness mucoperiosteal flap will be elevated to provide adequate access to the periodontal defect and root surfaces. Granulation tissue will be carefully removed, and thorough root surface debridement will be performed using manual and ultrasonic instrumentation. In the test group, laser irradiation will subsequently be performed within the periodontal pocket and on the exposed root surface as an adjunctive decontamination procedure. After instrumentation, laser treatment, and irrigation of the surgical site, the flap will be repositioned and stabilized with sutures to achieve appropriate wound closure.",[34],[52],"Laser assisted Periodontal surgery",[54,57,59],{"name":55,"affiliation":5,"role":56},"Giuseppe D'Albis, Dr","PRINCIPAL_INVESTIGATOR",{"name":58,"affiliation":5,"role":56},"Mattia Marra, Dr",{"name":60,"affiliation":5,"role":61},"Saverio Capodiferro, Prof","STUDY_DIRECTOR",[63,68],{"name":64,"role":65,"phone":66,"phoneExt":17,"email":67},"Giuseppe D'Albis, Dr.","CONTACT","3495103642","giuseppe.dalbis@uniba.it",{"name":69,"role":65,"phone":17,"phoneExt":17,"email":70},"Mattia Marra, Dr.","mattiamarra21@gmail.com",[72],{"facility":5,"status":17,"city":73,"state":74,"zip":75,"country":76,"countryCode":77,"cosmosGeoPoint":78,"geoPoint":83,"contacts":84},"Bari","BA","70042","Italy","IT",{"type":79,"coordinates":80},"Point",[81,82],16.86982,41.12066,{"lat":82,"lon":81},[85,86,87,88,89],{"name":64,"role":65,"phone":66,"phoneExt":17,"email":67},{"name":69,"role":65,"phone":17,"phoneExt":17,"email":70},{"name":55,"role":56,"phone":17,"phoneExt":17,"email":17},{"name":58,"role":56,"phone":17,"phoneExt":17,"email":17},{"name":60,"role":56,"phone":17,"phoneExt":17,"email":17},{"type":56,"investigatorFullName":91,"investigatorTitle":92,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Giuseppe D'Albis","Principal investigator","100655022","laser-assisted-open-flap-debridement-100655022",false,"NCT07807215","Laser Assisted Open Flap Debridement","A Comparative Evaluation of Laser Assisted Open Flap Debridement: A Clinical Trial","LaserOpen","Inclusion Criteria:\n\n* Adults in good general health\n* Signed informed consent\n* Periodontal disease treated with non surgical step.\n\nExclusion Criteria:\n\n* Systemic conditions affecting bone healing\n* Uncontrolled periodontal disease\n* Smoking \\>10 cigarettes\u002Fday\n* Pregnancy or lactation\n* Use of medications interfering with bone metabolism",true,"ALL",{"count":104,"type":105},20,"ESTIMATED","INTERVENTIONAL",[108],"NA","The study involves the surgical treatment of patients with Stage I to III of periodontitis. Following completion of Steps 1 and 2 of periodontal therapy according to the EFP guidelines for the treatment of periodontitis, sites presenting with residual probing depths greater than 5 mm and non-contained periodontal defects will undergo open-flap debridement and decontamination.\n\nIn one group, debridement and decontamination will be performed using manual and ultrasonic instrumentation, whereas in the other group, the same treatment will be supplemented with laser therapy.",[111,112],"Periodontal Disease","Periodontal Bone Loss",[114,115,116,117,118,119],"Periodontitis","Laser","Open Flap","Minimally invasive","Coagulation","decontamination","NOT_YET_RECRUITING","2026-09-05",{"date":123,"type":124},"2026-09-10","ACTUAL",{"date":123,"type":105},{"date":127,"type":105},"2026-11-10",{"name":5,"class":6},1]