[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100658120":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":20,"studyPopulation":13,"armGroups":21,"interventions":34,"overallOfficials":42,"centralContacts":46,"locations":13,"responsibleParty":52,"collaborators":13,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":13,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":13,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":85,"whyStopped":13,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":13},{"fullName":5,"class":6},"Allied Hospital Faisalabad","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Postoperative pain score","Postoperative pain will be assessed using the Visual Analogue Scale (VAS), ranging from 0 to 10, where 0 represents no pain and 10 represents the worst imaginable pain.","24 hours after surgery (postoperative day 1), before administration of the scheduled postoperative analgesic",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":13},"NONE","Hemorrhoidal disease is associated with symptomatic enlargement and\u002For prolapse of the anal cushions and is a common anorectal condition. Although many patients can be managed conservatively or with office-based procedures, symptomatic hemorrhoids with persistent symptoms or significant prolapse may require surgical treatment.\n\nOpen Milligan-Morgan hemorrhoidectomy is an established surgical treatment for advanced symptomatic hemorrhoidal disease. Its effectiveness is accompanied by postoperative surgical wounds, which may contribute to postoperative pain and delayed recovery. Laser hemorrhoidoplasty is a less invasive, non-excisional technique in which laser energy is delivered submucosally to produce thermal coagulation and subsequent shrinkage of hemorrhoidal tissue.\n\nPrevious comparative evidence has suggested that laser hemorrhoidoplasty may be associated with less postoperative pain and reduced analgesic requirements compared with conventional excisional hemorrhoidectomy. However, comparative evidence from South Asian populations remains limited. In addition, the use of laser hemorrhoidoplasty in a high-volume public-sector tertiary care setting involves specialized equipment and consumables, making evaluation of its clinical outcomes in the local setting relevant.\n\nThis randomized controlled trial has been designed to directly compare postoperative pain following laser hemorrhoidoplasty and open Milligan-Morgan hemorrhoidectomy. Pain will be evaluated using a standardized Visual Analogue Scale, with assessment performed before administration of scheduled postoperative analgesia to reduce the potential influence of analgesic administration on pain measurement.\n\nThe study will also examine postoperative analgesic requirements and relevant postoperative complications. The findings are intended to provide locally relevant clinical evidence regarding postoperative pain and early postoperative recovery following these two surgical approaches.",[22,28],{"label":23,"type":24,"description":25,"interventionNames":26},"Open Milligan-Morgan Hemorrhoidectomy","ACTIVE_COMPARATOR","Participants allocated to this group will undergo open Milligan-Morgan hemorrhoidectomy for symptomatic grade II, III, or IV internal hemorrhoids.",[27],"Procedure: Open Milligan-Morgan Hemorrhoidectomy",{"label":29,"type":30,"description":31,"interventionNames":32},"Laser Hemorrhoidoplasty","EXPERIMENTAL","Participants allocated to this group will undergo laser hemorrhoidoplasty (LHP) for symptomatic grade II, III, or IV internal hemorrhoids.",[33],"Procedure: Laser Hemorrhoidoplasty",[35,39],{"type":36,"name":23,"description":37,"armGroupLabels":38,"otherNames":13},"PROCEDURE","Participants allocated to this group will undergo open Milligan-Morgan hemorrhoidectomy for the treatment of symptomatic grade II, III, or IV internal hemorrhoids. The procedure will be performed as per the standard surgical practice of the institution.",[23],{"type":36,"name":29,"description":40,"armGroupLabels":41,"otherNames":13},"Participants allocated to this group will undergo laser hemorrhoidoplasty (LHP) for the treatment of symptomatic grade II, III, or IV internal hemorrhoids. Laser energy will be applied using a submucosal approach to produce thermal coagulation followed by shrinkage of the hemorrhoidal tissue.",[29],[43],{"name":44,"affiliation":5,"role":45},"Muhammad Faisal Bilal Lodhi, MBBS, FCPS General Surgery","STUDY_CHAIR",[47],{"name":48,"role":49,"phone":50,"phoneExt":13,"email":51},"Abdul Basit, MBBS","CONTACT","+92 301 6705830","abdulbasit.ab361@gmail.com",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Abdul Basit","Postgraduate resident","100658120","laser-hemorrhoidoplasty-versus-open-hemorrhoidectomy-for-postoperative-pain-100658120",false,"NCT07846904","Laser Hemorrhoidoplasty Versus Open Hemorrhoidectomy for Postoperative Pain","Comparison of Postoperative Pain Between Laser Haemorrhoidoplasty and Open Haemorrhoidectomy","Inclusion Criteria Adult patients aged 20-50 years. Patients of either sex. Patients diagnosed with symptomatic Grade II, III, or IV internal hemorrhoids based on clinical examination and proctoscopy\u002Fanoscopy.\n\nPatients fit for elective surgery under anesthesia, classified as ASA physical status I or II.\n\nPatients providing written informed consent to participate in the study. Exclusion Criteria Pregnant females. Patients with Grade I hemorrhoids or purely external hemorrhoids. Patients presenting with strangulated, thrombosed, or gangrenous hemorrhoids requiring emergency surgical intervention.\n\nPatients with associated anorectal pathologies, including anal fissure, fistula-in-ano, inflammatory bowel disease, or anorectal malignancy.\n\nPatients with bleeding diathesis or deranged coagulation profiles, including prolonged PT, APTT, or INR.\n\nPatients with chronic liver disease or portal hypertension. Patients classified as ASA physical status III or IV. Immunocompromised patients, including those with confirmed HIV infection.","ALL","20 Years","50 Years",{"count":67,"type":68},68,"ESTIMATED","INTERVENTIONAL",[71],"NA","Hemorrhoidal disease is a common condition that can cause symptoms such as rectal bleeding and protrusion of tissue through the anal canal. For patients with symptomatic grade II, III, or IV internal hemorrhoids who require surgery, different surgical techniques are available.\n\nThis randomized controlled trial will compare postoperative pain between two surgical treatments for hemorrhoids: laser hemorrhoidoplasty and open Milligan-Morgan hemorrhoidectomy. The study will include adult patients aged 20-50 years with symptomatic grade II, III, or IV internal hemorrhoids who are suitable for elective surgery.\n\nA total of 68 participants will be enrolled and randomly allocated in a 1:1 ratio to either open Milligan-Morgan hemorrhoidectomy or laser hemorrhoidoplasty. Postoperative pain will be assessed using the Visual Analogue Scale (VAS), which ranges from 0 (no pain) to 10 (worst imaginable pain). The primary outcome will be the VAS pain score 24 hours after surgery. Pain will also be assessed 72 hours after surgery as a secondary outcome.\n\nThe study will also record the need for rescue analgesia and the total amount of rescue tramadol administered during the first 72 hours after surgery. Relevant postoperative complications will also be monitored.\n\nThe purpose of the study is to determine whether there is a difference in postoperative pain between laser hemorrhoidoplasty and open Milligan-Morgan hemorrhoidectomy. The findings may provide locally relevant information regarding postoperative pain and early recovery following these two surgical approaches.",[74],"Hemorrhoid",[76,77,78,79,80,81,82,83,84],"Hemorrhoids","Internal hemorrhoids","Laser hemorrhoidoplasty","Milligan-Morgan hemorrhoidectomy","Postoperative pain","Visual Analogue Scale","Hemorrhoidectomy","Rescue analgesia","Randomized controlled trial","NOT_YET_RECRUITING","2026-09-23",{"date":88,"type":89},"2026-09-29","ACTUAL",{"date":91,"type":68},"2026-11",{"date":93,"type":68},"2027-03",{"name":5,"class":6}]