[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654288":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":31,"studyPopulation":32,"armGroups":27,"interventions":27,"overallOfficials":33,"centralContacts":38,"locations":27,"responsibleParty":44,"collaborators":27,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":27,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":27,"enrollmentInfo":57,"targetDuration":60,"studyType":61,"phases":27,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":75,"whyStopped":27,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":27},{"fullName":5,"class":6},"Assiut University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":27},[9],{"measure":10,"description":11,"timeFrame":12},"6-month major adverse cardiovascular events (MACE)","Composite of cardiac death, recurrent myocardial infarction, heart failure hospitalization, or life-threatening arrhythmia occurring within 6 months of admission.","6 months",[14,18,21,24],{"measure":15,"description":16,"timeFrame":17},"Left atrial reservoir strain","Peak atrial longitudinal strain (PALS) during the reservoir phase measured by two-dimensional speckle tracking echocardiography (EchoPAC software), expressed as percentage (%). Higher values indicate better left atrial function.","Baseline",{"measure":19,"description":20,"timeFrame":12},"Change in risk discrimination with addition of LA reservoir strain","Change in risk discrimination for 6-month MACE when left atrial reservoir strain is added to the GRACE 2.0 score, left ventricular ejection fraction (LVEF), and left atrial volume index (LAVI), assessed by change in C-statistic, Net Reclassification Improvement (NRI), and Integrated Discrimination Improvement (IDI).",{"measure":22,"description":23,"timeFrame":12},"Optimal cutoff value of LA reservoir strain","Optimal cutoff value of left atrial reservoir strain for predicting 6-month MACE determined by receiver operating characteristic (ROC) curve analysis.",{"measure":25,"description":26,"timeFrame":17},"Correlation of LA reservoir strain with clinical parameters","Correlation between left atrial reservoir strain (expressed as percentage) and the following parameters: GRACE 2.0 score, peak troponin level (ng\u002FL), left ventricular ejection fraction (%), and E\u002Fe' ratio. Correlation will be assessed using Pearson or Spearman correlation coefficient.",null,{"allocation":27,"interventionModel":27,"interventionModelDescription":27,"primaryPurpose":27,"observationalModel":29,"timePerspective":30,"maskingInfo":27},"COHORT","PROSPECTIVE","Non-ST-elevation myocardial infarction (NSTEMI) carries significant short- and long-term risk of major adverse cardiovascular events despite advances in management. Current risk stratification relies on clinical scores such as GRACE 2.0 and conventional echocardiographic parameters including left ventricular ejection fraction (LVEF) and left atrial volume index (LAVI). These tools have limitations, as LVEF may remain preserved and LAVI mainly reflects chronic remodeling.\n\nLeft atrial (LA) reservoir strain assessed by two-dimensional speckle tracking echocardiography is a sensitive marker of left ventricular filling pressure and diastolic function. Reduced LA reservoir strain has been associated with adverse outcomes after NSTEMI, but data on its incremental prognostic value beyond established risk models remain limited.\n\nThis prospective observational study will assess whether LA reservoir strain independently predicts 6-month MACE and improves risk discrimination when added to the GRACE 2.0 score and conventional echocardiographic parameters in patients with NSTEMI.","Adult patients admitted with NSTEMI to the Cardiology Department \u002F Coronary Care Unit of Assiut University Hospital who meet the eligibility criteria.",[34],{"name":35,"affiliation":36,"role":37},"Hatem A Helmy, prof","Department of Cardiology, Faculty of Medicine, Assiut University","STUDY_CHAIR",[39],{"name":40,"role":41,"phone":42,"phoneExt":27,"email":43},"Ahmed A Abu Al-Abbass","CONTACT","0 10 03702766","ahmed.18313356@med.aun.edu.eg",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Ahmed Ali Abu Al-Abbass","Resident","100654288","left-atrial-strain-for-predicting-mace-in-nstemi-100654288",false,"NCT07797634","Left Atrial Strain for Predicting MACE in NSTEMI","Incremental Prognostic Value of Left Atrial Reservoir Strain Beyond the GRACE 2.0 Score and Conventional Echocardiographic Parameters for Predicting 6-Month MACE in Patients With NSTEMI","Inclusion Criteria:\n\n* Age \\> 18 years\n* Confirmed diagnosis of NSTEMI according to current ESC\u002FACC guidelines\n* Willingness to provide informed consent and complete 6-month follow-up\n* Undergoing coronary angiography or revascularization during the index hospitalization\n\nExclusion Criteria:\n\n* ST-elevation myocardial infarction (STEMI)\n* Atrial fibrillation or other significant arrhythmia at presentation\n* Moderate to severe valvular heart disease (especially mitral valve disease)\n* Prior cardiac surgery or valve replacement\n* Poor echocardiographic image quality precluding reliable strain analysis\n* Chronic kidney disease on dialysis\n* Known cardiomyopathy (hypertrophic, dilated, or infiltrative)\n* Pregnancy\n* Refusal to participate","ALL","18 Years",{"count":58,"type":59},150,"ESTIMATED","6 Months","OBSERVATIONAL","This prospective observational study aims to evaluate whether left atrial reservoir strain, measured by two-dimensional speckle tracking echocardiography, independently predicts 6-month major adverse cardiovascular events (MACE) and provides incremental prognostic value beyond the GRACE 2.0 score, left ventricular ejection fraction, and left atrial volume index in patients with non-ST-elevation myocardial infarction.",[64,65,66],"Non-ST Elevation Myocardial Infarction (NSTEMI)","Acute Coronary Syndrome","Myocardial Infarction",[68,69,70,71,72,73,74],"Left atrial strain","Reservoir strain","Speckle tracking echocardiography","GRACE score","Major adverse cardiovascular events","NSTEMI","Prognostic value","NOT_YET_RECRUITING","2026-08-28",{"date":78,"type":79},"2026-09-01","ACTUAL",{"date":81,"type":59},"2026-08-26",{"date":83,"type":59},"2028-05-25",{"name":5,"class":6}]