[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630778":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":35,"responsibleParty":52,"collaborators":20,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":20,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":20,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Test Leucine Intakes","EXPERIMENTAL","Randomized to receive 1 of 7 leucine intake levels (10, 20, 30, 40, 50, 60 or 80 mg\u002Fkg\u002Fd). Participants will complete up to 5 test intake allocations.",[13],"Dietary Supplement: Leucine Intake",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","Leucine Intake","Participants consume 8 hourly meals that contain the assigned test leucine intake. Each meal will provide one-twelfth of the participants' daily energy requirements as estimated by 1.7 x Resting Energy Expenditure (REE) and adequate protein at 1.5 g\u002Fkg\u002Fd, to maintain a metabolic steady state. The meals are in the form of a crystalline amino acid protein shake, and protein-free cookies.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Rajavel Elango","PRINCIPAL_INVESTIGATOR",[26,32],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Kendall Plant","CONTACT","604-875-2000","4607","kendall.plant@bcchr.ca",{"name":23,"role":28,"phone":29,"phoneExt":33,"email":34},"4911","relango@bcchr.ubc.ca",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"BC Children's Hospital Research Institute","RECRUITING","Vancouver","British Columbia","V5Z 4H4","Canada","CA",{"type":45,"coordinates":46},"Point",[47,48],-123.11934,49.24966,{"lat":48,"lon":47},[51],{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Rajavel Elango, PhD","Principal Investigator","100630778","leucine-requirements-in-school-age-children-100630778",false,"NCT07492095","Leucine Requirements in School-Age Children","Determination of Leucine Requirements in Healthy School-Age Children Using the Indicator Amino Acid Oxidation Method","Inclusion Criteria:\n\n* Healthy children\n* Aged 6 to 10 years at enrollment\n* Body weight between the 3rd and 85th percentile according to WHO Child Growth Standards\n* Assent from the child and written informed consent from parent(s) and\u002For legal guardian(s)\n\nExclusion Criteria:\n\n* Diagnosis of any acute or chronic medical condition\n* Current use of prescription medication that may affect protein or energy metabolism\n* Recent weight loss\n* Recent illness (fever, vomiting, severe runny nose within the past 5 days)\n* Inability to comply with study procedures",true,"ALL","6 Years","10 Years",{"count":67,"type":68},7,"ESTIMATED","INTERVENTIONAL",[71],"NA","Leucine is an essential amino acid, which serves a special purpose of signaling cell growth in muscle in addition to making up protein. Essential amino acids like leucine need to be eaten every day from our foods like meat, dairy, eggs, beans, and nuts, as they cannot be made by our bodies. The current recommendation for leucine in the diet of school-age children are based upon adult needs. This study will measure the leucine requirement in children aged 6-10 years old using an non-invasive technique with special diets, safe stable isotopes, and simple breath collections. Creating guidelines based on measured requirements for leucine in this age group is essential for supporting optimal growth in healthy children.",[74],"Nutrient Intake",[76,77,78,79],"Leucine","School-Age Children","Amino Acid","Isotope","2026-07-06",{"date":82,"type":83},"2026-07-08","ACTUAL",{"date":85,"type":83},"2026-06-25",{"date":87,"type":68},"2027-12-31",{"name":5,"class":6},1]