[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646680":3},{"organization":4,"outcomesModule":7,"designInfo":22,"detailedDescription":28,"studyPopulation":21,"armGroups":29,"interventions":36,"overallOfficials":21,"centralContacts":42,"locations":48,"responsibleParty":65,"collaborators":21,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":21,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":21,"studyType":82,"phases":83,"briefSummary":84,"conditions":85,"keywords":21,"overallStatus":88,"whyStopped":21,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Virginia Polytechnic Institute and State University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":21,"otherOutcomes":21},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Safety - monitoring of possible symptoms","Symptom monitoring before and after LIFU applications and throughout 6 months of follow-up. Each symptom is presented with a likert scale (absent, mild, moderate, severe) - along with a free response option for any symptoms not included in the list.","Throughout study participation at multiple time points, approximately 6 months.",{"measure":14,"description":15,"timeFrame":16},"Changes in Chronic Pain - self report","Participants will complete the Brief Pain Inventory (BPI) at multiple time points throughout the 6 month period. This questionnaire asks participants to rate their pain on a 10 point scale (10 being the most pain).","Multiple timepoints throughout the 6 month experimental timeframe.",{"measure":18,"description":19,"timeFrame":20},"Changes in Anxiety - self report","Participants will complete the Beck Anxiety Inventory (BAI) at multiple time points before and after LIFU application to track changes in anxiety throughout the 6 month timeframe. The BAI probes different symptoms of anxiety and participants rate it on a likert scale (not at all, mildly, moderately, or severely).","Throughout the experimental timeframe, approximately 6 months.",null,{"allocation":23,"interventionModel":24,"interventionModelDescription":21,"primaryPurpose":25,"observationalModel":21,"timePerspective":21,"maskingInfo":26},"NA","SINGLE_GROUP","TREATMENT",{"masking":27,"maskingDescription":21,"whoMasked":21},"NONE","A single-arm, open label, 2 cohort (chronic pain\u002FGAD) case study with extended (6 months) follow-up following accelerated low-intensity focused ultrasound for neuromodulation.",[30],{"label":31,"type":32,"description":33,"interventionNames":34},"Low-intensity focused ultrasound for neuromodulation","EXPERIMENTAL","Accelerated (repeat) LIFU application for neuromodulation",[35],"Device: Low Intensity Focused Ultrasound",[37],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":21},"DEVICE","Low Intensity Focused Ultrasound","Low-Intensity Focused Ultrasound applied multiple times in a single study visit.",[31],[43],{"name":44,"role":45,"phone":46,"phoneExt":21,"email":47},"Jessica Research Associate, MPH","CONTACT","540-526-2261","jnw@vtc.vt.edu",[49],{"facility":50,"status":21,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Fralin Biomedical Research Institute at VTC","Roanoke","Virginia","24016","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-79.94143,37.27097,{"lat":60,"lon":59},[63],{"name":44,"role":45,"phone":64,"phoneExt":21,"email":47},"5405262261",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Wynn Legon","Assistant Professor","100646680","lifu-for-chronic-pain-and-generalized-anxiety-disorder-100646680",false,"NCT07686354","LIFU for Chronic Pain and Generalized Anxiety Disorder","Accelerated Low-Intensity Focused Ultrasound (LIFU) for Chronic Pain and Generalized Anxiety Disorder: A Proof-of-Concept Case Series","Inclusion Criteria:\n\n* GAD Symptoms - GAD-7 score \\>= 10, OASIS score \\>= 8, or PSWQ score \\>= 45. OR Chronic pain symptoms - moderate to severe pain, present for at least 3 months.\n\nExclusion Criteria:\n\n* Claustrophobia\n* Contraindications to MRI or CT\n* Active medical disorder with CNS effects\n* History of neurologic disorder\n* History of head injury with LOC \\> 10 minutes\n* Active drug or alcohol dependence","ALL","18 Years","65 Years",{"count":80,"type":81},10,"ESTIMATED","INTERVENTIONAL",[23],"A proof of concept case study to investigate accelerated LIFU protocol in chronic pain and anxiety populations.",[86,87],"Chronic Pain","Generalized Anxiety Disorder","NOT_YET_RECRUITING","2026-09-10",{"date":91,"type":92},"2026-09-11","ACTUAL",{"date":94,"type":81},"2026-10",{"date":96,"type":81},"2027-12",{"name":5,"class":6},1]