[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650720":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":37,"centralContacts":42,"locations":30,"responsibleParty":47,"collaborators":30,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":30,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":72,"whyStopped":30,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":30},{"fullName":5,"class":6},"Taipei Medical University Shuang Ho Hospital","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"LLM Conversation Cognitive Interaction","EXPERIMENTAL","Participants will complete a 12-week, home-based cognitive intervention using a large language model-driven conversation platform. They will use the platform five times per week for approximately 20 minutes per session.\n\nThe platform will begin each session with a brief conversation about the participant's recent experiences. Participants will then select a topic based on their interests and discuss a short topic summary with the platform. The conversations will include activities designed to engage memory, attention, language, executive function, and social cognition. The platform will adjust the depth of questions and follow-up prompts based on the participant's responses.\n\nResearch staff will provide two initial in-person training sessions and weekly video-call follow-up. Technical support and adherence reminders will be provided through the LINE platform.",[13],"Behavioral: LLM Conversation Cognitive Interaction",{"label":15,"type":16,"description":17,"interventionNames":18},"Interest-Based Knowledge Reading","ACTIVE_COMPARATOR","Participants will complete a 12-week, home-based reading intervention using an interest-based knowledge reading platform. They will use the platform five times per week for approximately 20 minutes per session.\n\nDuring each session, participants will briefly report on their recent experiences and select topics based on their interests. The platform will provide four short news summaries, including familiar and unfamiliar topics and both preferred and non-preferred topics. Participants will answer five multiple-choice questions after each summary to support attention and understanding of the content.\n\nResearch staff will provide two initial in-person training sessions and weekly video-call follow-up. Technical support and adherence reminders will be provided through the LINE platform.",[19],"Behavioral: Interest-Based Knowledge Reading",{"label":21,"type":6,"description":22,"interventionNames":23},"Waitlist Health Education","Participants will receive general health education materials once per week for 12 weeks through the LINE platform. They will not receive the conversation or reading intervention during the initial 12-week study period.\n\nAfter completing the post-intervention assessments, participants will be offered an opportunity to receive one of the two cognitive interventions. Their later intervention assignment will not be included in the primary comparison of the randomized trial.",[24],"Behavioral: Waitlist Health Education",[26,31,34],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","A voice-based cognitive stimulation program delivered through a large language model-driven conversational platform. The platform uses topics selected according to each participant's interests and guides natural conversations designed to engage memory, attention, language, executive function, and social cognition.\n\nThe platform provides topic summaries, asks questions, responds to participants' answers, and adjusts the depth of follow-up questions based on response quality. Conversation responses are converted into text and used to generate indicators of cognitive performance. The platform is intended for cognitive stimulation and does not provide a clinical diagnosis.",[9],null,{"type":27,"name":15,"description":32,"armGroupLabels":33,"otherNames":30},"A digital cognitive activity that provides short news and knowledge summaries based on participants' interests. The content includes both familiar and unfamiliar topics, as well as preferred and non-preferred topics, to provide varied cognitive challenges.\n\nParticipants answer multiple-choice questions about each summary. The questions are designed to engage reading comprehension, attention, and memory for the presented information.",[15],{"type":27,"name":21,"description":35,"armGroupLabels":36,"otherNames":30},"General health education materials for older adults delivered through the LINE platform. The materials provide information related to healthy aging and general health management but do not include structured conversational cognitive stimulation or interest-based reading exercises.",[21],[38],{"name":39,"affiliation":40,"role":41},"Hsinchieh Lee","Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei","PRINCIPAL_INVESTIGATOR",[43],{"name":39,"role":44,"phone":45,"phoneExt":30,"email":46},"CONTACT","0929722265","kyoko70385@gmail.com",{"type":48,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100650720","llm-driven-daily-conversation-for-cognitive-health-in-older-adults-100650720",false,"NCT07751510","LLM-Driven Daily Conversation for Cognitive Health in Older Adults","A Large Language Model-Driven Daily Conversation Cognitive Interaction Platform: Feasibility and Preliminary Efficacy in Older Adults at High Risk of Dementia","LLM-DCI","Inclusion Criteria\n\nStage 1: Feasibility Study\n\nParticipants must belong to one of the following groups:\n\nHealthy younger adults aged 18 to 40 years. Older adults with normal cognitive function aged 65 years or older and a Montreal Cognitive Assessment score of 24 or higher.\n\nOlder adults with cognitive impairment aged 65 years or older and a Montreal Cognitive Assessment score of 18 to 23.\n\nParticipants must have completed at least elementary school, corresponding to 6 or more years of education.\n\nParticipants must be able to read and write Chinese, communicate in Chinese, and understand the study content.\n\nParticipants must be able to use a tablet or smartphone independently or with assistance from a family member.\n\nParticipants must have sufficient hearing and vision, with usual corrective devices if needed, to complete the study tasks.\n\nStage 2: Preliminary Efficacy Study\n\nParticipants must be aged 65 years or older.\n\nParticipants must be considered at high risk of dementia by meeting at least one of the following conditions:\n\n1. Subjective cognitive decline:\n\n   A Subjective Cognitive Decline Questionnaire score greater than 7 out of 24.\n\n   A response of yes to both of the following questions:\n\n   Compared with your previous usual condition, do you have memory problems? Have your family members or close contacts noticed memory problems compared with your previous condition? Performance within the normal range on standardized cognitive tests, defined as scores no more than 1.5 standard deviations below age- and education-adjusted norms on the Color Trails Test and memory-related assessments.\n2. Mild cognitive impairment:\n\n   A diagnosis of mild cognitive impairment made by a neurologist or psychiatrist according to accepted diagnostic criteria.\n\n   Evidence of memory performance at least 1.5 standard deviations below age- and education-adjusted normative values on at least one subtest of the Wechsler Memory Scale, Third Edition.\n3. Limited social interaction:\n\n   Living alone, living with a person who cannot provide care, or living with a person who is absent for at least 3 days per week; or A score below 12 on the 6-item Lubben Social Network Scale.\n4. Chronic disease:\n\nA physician diagnosis of hypertension or diabetes for at least 1 year; and A need for ongoing medication or lifestyle management. Participants must have completed at least elementary school, corresponding to 6 or more years of education.\n\nParticipants must be able to read and write Chinese, communicate in Chinese, and understand news and study-related content.\n\nParticipants must be able to use a tablet or smartphone independently or with assistance from a family member.\n\nParticipants must have sufficient hearing and vision, with usual corrective devices if needed, to complete the conversation and reading tasks.\n\nExclusion Criteria\n\nA diagnosis of dementia or a severe neurodegenerative disorder, such as moderate-to-advanced Parkinson disease or Huntington disease.\n\nA history of a severe psychiatric disorder, such as schizophrenia or severe bipolar disorder, or current acute psychiatric symptoms that may interfere with understanding or responding during conversations.\n\nA major neurological event within the previous 6 months, such as stroke or severe traumatic brain injury, that may substantially affect cognitive or language function.\n\nSevere hearing, speech, or language impairment that prevents basic verbal communication, even when assistive devices are used.\n\nAn acute medical illness, active infection, or any condition considered by a physician to make study participation inappropriate.\n\nInability to complete a 20-minute conversation task or unwillingness to allow collection of interaction data.",true,"ALL","18 Years","90 Years",{"count":62,"type":63},75,"ESTIMATED","INTERVENTIONAL",[66],"NA","This study will develop and test a daily conversation platform that uses a large language model, a type of artificial intelligence, to support cognitive health in older adults at high risk of dementia.\n\nThe platform will guide participants through voice-based conversations about topics that interest them. The conversations are designed to engage memory, attention, language, planning and problem-solving, and the ability to understand social situations. The platform will also analyze conversation data and create a report describing the participant's cognitive performance.\n\nThe study has two stages. In the first stage, 15 participants will test the platform through two 20-minute conversation sessions. This group will include healthy younger adults, older adults with normal cognitive function, and older adults with cognitive difficulties. Participants will provide feedback on how easy and acceptable the platform is to use.\n\nIn the second stage, 60 older adults at high risk of dementia will be randomly assigned to one of three groups. The groups will receive either conversation-based cognitive activities using the platform, interest-based news reading activities, or weekly health education while waiting to receive the intervention. The study activities will continue for 12 weeks. Researchers will compare changes in cognitive function, emotional well-being, loneliness, social connection, and user experience before and after the study.\n\nThe main goals are to learn whether the platform is practical and acceptable for home use and whether it may help support cognitive and psychosocial health.",[69],"Subjective Cognitive Decline",[71],"Large Language Model; Conversational Cognitive Stimulation; Older Adults at High Risk of Dementia; Cognitive Function; Psychosocial Function","NOT_YET_RECRUITING","2026-08-03",{"date":75,"type":76},"2026-08-07","ACTUAL",{"date":78,"type":63},"2026-09-01",{"date":80,"type":63},"2027-06-30",{"name":5,"class":6}]