[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650825":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":32,"collaborators":26,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":26,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":26,"enrollmentInfo":45,"targetDuration":26,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":26,"overallStatus":55,"whyStopped":26,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":61,"leadSponsor":63,"locationsCount":26},{"fullName":5,"class":6},"Seoul National University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Local Anesthetic Infiltration Group","EXPERIMENTAL","Participants receive a subcutaneous\u002Fsubfascial injection at the incision site before skin closure, containing 0.75% ropivacaine 20 mL, morphine 10 mg, ketorolac 30 mg, epinephrine 0.3 mg, and cefuroxime 750 mg (total 50 mL).",[13],"Combination Product: Ropivacaine-Morphine-Ketorolac-Epinephrine-Cefuroxime Mixture",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Control Group","PLACEBO_COMPARATOR","Participants receive a subcutaneous\u002Fsubfascial injection at the incision site before skin closure, containing cefuroxime 750 mg and normal saline (total 50 mL).",[19],"Drug: Cefuroxime-Saline Mixture",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","Ropivacaine-Morphine-Ketorolac-Epinephrine-Cefuroxime Mixture","A single subcutaneous\u002Fsubfascial injection administered at the incision site before skin closure, consisting of 0.75% ropivacaine 20 mL, morphine sulfate 10 mg, ketorolac 30 mg, epinephrine 0.3 mg, and cefuroxime 750 mg, mixed to a total volume of 50 mL.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Cefuroxime-Saline Mixture","A single subcutaneous\u002Fsubfascial injection administered at the incision site before skin closure, consisting of cefuroxime 750 mg and normal saline, mixed to a total volume of 50 mL.",[15],{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Chang-Hoon Koo","Clinical Associate Professor","100650825","local-anesthetic-infiltration-for-pain-control-after-orthopedic-wide-excision-100650825",false,"NCT07753629","Local Anesthetic Infiltration for Pain Control After Orthopedic Wide Excision","Analgesic Effect of Subcutaneous Local Infiltration Anesthesia Before Skin Closure on Postoperative Pain in Patients Undergoing Orthopedic Wide Excision: A Prospective Double-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Scheduled to undergo elective orthopedic wide excision surgery under general anesthesia\n* American Society of Anesthesiologists (ASA) Physical Status Classification 1, 2, or 3\n* Age 19 years or older\n\nExclusion Criteria:\n\n* Unwilling to provide informed consent\n* History of allergy to local anesthetics\n* History of chronic pain\n* Use of opioid analgesics within 24 hours before surgery\n* Active infection at the surgical site","ALL","19 Years",{"count":46,"type":47},58,"ESTIMATED","INTERVENTIONAL",[50],"NA","This study evaluates whether injecting a local anesthetic mixture (ropivacaine, morphine, ketorolac, and epinephrine) under the skin at the incision site before wound closure reduces pain after orthopedic wide excision surgery for bone or soft tissue tumors. Participants will be randomly assigned to receive either the local anesthetic mixture or a saline control injection. Neither participants nor the study team assessing outcomes will know which treatment was given. The main goal is to determine whether this injection reduces the amount of opioid pain medication needed during the first 24 hours after surgery. The study will also assess pain scores, nausea and vomiting, and quality of recovery.",[53,54],"Wide Excision","Postoperative Pain","NOT_YET_RECRUITING","2026-08-03",{"date":58,"type":59},"2026-08-07","ACTUAL",{"date":58,"type":47},{"date":62,"type":47},"2028-07-31",{"name":5,"class":6}]