[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100467920":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":49,"responsibleParty":69,"collaborators":32,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":32,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":32,"enrollmentInfo":81,"targetDuration":32,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":32,"overallStatus":51,"whyStopped":32,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Rehabilitation","EXPERIMENTAL","Participants will be assigned to the Exercise+Placebo or Exercise+Mito-Q rehabilitation interventions using block randomization (block size 10).",[13],"Dietary Supplement: Mitoquinone",{"label":15,"type":16,"description":17,"interventionNames":18},"Exercise Rehabilitation with Placebo","PLACEBO_COMPARATOR","Participants will be assigned to Exercise+Placebo rehabilitation using block randomization (block size 10)",[13,19],"Dietary Supplement: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Mitoquinone","Mito-Q is a supplement that targets mitochondrial function. Linking a triphenyl-phosphonium cation to coenzyme-Q, to produce Mito-Q, results in a lipophilic compound, which, due to the large mitochondrial membrane potential, selectively accumulates within mitochondria. This targeted antioxidant approach results in 50- to 100-fold more Mito-Q accumulation compared to non-targeted antioxidant delivery.",[9,15],[27],"MitoQ",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo","A placebo will be used in combination with exercise rehabilitation allowing for a double blinded placebo controlled design.",[15],null,[34],{"name":35,"affiliation":36,"role":37},"Joel Douglas Trinity, PhD","VA Salt Lake City Health Care System, Salt Lake City, UT","PRINCIPAL_INVESTIGATOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Joel D Trinity, PhD","CONTACT","(801) 582-1565","1199","Joel.Trinity@va.gov",{"name":46,"role":41,"phone":42,"phoneExt":47,"email":48},"Russell S Richardson, PhD","4344","r.richardson@hsc.utah.edu",[50],{"facility":36,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Salt Lake City","Utah","84148-0001","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-111.89105,40.76078,{"lat":61,"lon":60},[64,68],{"name":65,"role":41,"phone":42,"phoneExt":66,"email":67},"P Jon White, MD","4897","Paul.White2@va.gov",{"name":35,"role":37,"phone":32,"phoneExt":32,"email":32},{"type":70,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100467920","long-term-covid-and-rehabilitation-100467920",false,"NCT05373043","Long-term COVID and Rehabilitation","Evaluating the Long-term Health Consequences of COVID-19 and Rehabilitation Therapies to Speed Convalescence","Inclusion Criteria:\n\n* Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis\n* Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis\n* Ability to sign informed consent\n\nExclusion Criteria:\n\n* BMI \\>45 kg\u002Fm2\n* Unstable (\\\u003C6 months) or severe coronary artery disease (CAD-RADS score = 4A), peripheral artery disease (Ankle Brachial Index \\\u003C0.40), cerebrovascular disease (identified by previous stroke in last 12 months), severe COPD (=Stage III), uncontrolled hypertension (\\>160\u002F100 mmHg), chronic kidney disease requiring dialysis, severe renal insufficiency (creatinine clearance \\\u003C30 by the Cockcroft-Gault formula), Alzheimer's disease, dementia\n* Orthopedic limitations that would prohibit exercise\n* Current smokers and individuals that stopped smoking in the last 10 years\n* Already taking Mito-Q or unwilling to cease dietary supplements for participation\n* Any other condition or event considered exclusionary by the PIs or a physician",true,"ALL","18 Years",{"count":82,"type":83},300,"ESTIMATED","INTERVENTIONAL",[86],"NA","The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.",[89],"Long-COVID","2026-07-28",{"date":92,"type":93},"2026-07-30","ACTUAL",{"date":95,"type":93},"2022-11-01",{"date":97,"type":83},"2028-10-31",{"name":5,"class":6},1]