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Poisson regression (piece-wise exponential models) and Cox regression will be the primary methods of risk-factor analysis. When comparing study cohort with national rates, Poisson regression will be used. When the comparison is internal (ie, no use of national standard rates), Cox regression will be used.",{"measure":24,"description":11,"timeFrame":12},"Collection of cumulative therapeutic exposure data","PRIMARY OBJECTIVES:\n\nI. To develop a mechanism for tracking and retaining patients enrolled on Children's Oncology Group (COG) protocols.\n\nII. To maintain regular, lifetime contact with patients in order to obtain current identification and contact information, and self\u002Fparent-reported quality of life and health status.\n\nIII. To locate patients who are lost-to-follow-up for COG (or Legacy Group) protocols targeted for follow-up by the Long-Term Follow-Up Center (LTFC).\n\nIV. To provide current patient contact information and self\u002Fparent-reported health status updates to the COG Statistics and Data Center (SDC) and to each patient's COG institution.\n\nV. To facilitate collection of protocol-specific outcome data through collaboration with the LTFC Oversight Committee, the SDC, and the member institutions.\n\nOUTLINE: This is an umbrella protocol for all long-term follow-up at COG institutions.\n\nWithin 3 months of enrollment on ALTE05N1, patients receive a packet introducing the Long-Term Follow-Up Center (LTFC). Patients are asked to complete a patient response form, verify information provided in packet, and update contact and health status information. The Health Status Update Form is a brief document including questions about current health status, disease status, and cancer therapy received since the last mailing. Patients may respond by use of postage prepaid envelopes, secure online form, or 24-hour toll-free telephone number. After initial contact, the LTFC will contact the patient annually.",[27],{"label":28,"type":11,"description":29,"interventionNames":30},"Observational (long-term follow-up)","Within 3 months of enrollment on ALTE05N1, patients receive a packet introducing the Long-Term Follow-Up Center (LTFC). Patients are asked to complete a patient response form, verify information provided in packet, and update contact and health status information. The Health Status Update Form is a brief document including questions about current health status, disease status, and cancer therapy received since the last mailing. Patients may respond by use of postage prepaid envelopes, secure online form, or 24-hour toll-free telephone number. After initial contact, the LTFC will contact the patient annually",[31,32],"Procedure: Assessment of Therapy Complications","Other: Questionnaire Administration",[34,39],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":11},"PROCEDURE","Assessment of Therapy Complications","Complete patient response form and Health Status Update Form",[28],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":11},"OTHER","Questionnaire Administration","Complete patient response form, Health Status Update Form (called the \"Keep in Touch\" form), and Quality of Life Questionnaire (PROMIS)",[28],[45],{"name":46,"affiliation":5,"role":47},"Smita Bhatia","PRINCIPAL_INVESTIGATOR",[49,69,75,89,104,118,132,138,153,168,178,191,204,215,225,238,253,266,279,293,306,315,326,340,353,367,382,398,413,423,438,447,457,466,478,493,508,520,525,530,539,548,561,570,583,597,607,618,632,646,657,669,683,696,710,724,739,751,765,779,794,803,813,823,835,851,863,877,892,906,921,933,946,960,970,984,999,1013,1026,1041,1052,1068,1077,1086,1095,1111,1126,1140,1153,1164,1173,1186,1195,1211,1226,1241,1255,1269,1281,1294,1308,1322,1337,1351,1367,1382,1391,1403,1417,1432,1446,1462,1476,1489,1503,1515,1528,1541,1555,1561,1577,1591,1605,1617,1627,1636,1649,1662,1672,1685,1700,1716,1729,1741,1746,1762,1772,1786,1799,1813,1827,1840,1854,1866,1879,1894,1907,1913,1924,1938,1954,1964,1977,1986,2000,2014,2027,2040,2052,2066,2082,2096,2111,2126],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Children's Hospital of Alabama","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-86.80249,33.52066,{"lat":61,"lon":60},[64,68],{"name":65,"role":66,"phone":11,"phoneExt":11,"email":67},"Site Public Contact","CONTACT","helpdesk@childrensoncologygroup.org",{"name":46,"role":47,"phone":11,"phoneExt":11,"email":11},{"facility":70,"status":71,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":72,"geoPoint":74,"contacts":11},"University of Alabama at Birmingham Cancer Center","ACTIVE_NOT_RECRUITING",{"type":58,"coordinates":73},[60,61],{"lat":61,"lon":60},{"facility":76,"status":51,"city":77,"state":53,"zip":78,"country":55,"countryCode":56,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"USA Health Strada Patient Care Center","Mobile","36604",{"type":58,"coordinates":80},[81,82],-88.04305,30.69436,{"lat":82,"lon":81},[85,87],{"name":65,"role":66,"phone":86,"phoneExt":11,"email":11},"800-388-8721",{"name":88,"role":47,"phone":11,"phoneExt":11,"email":11},"Hamayun Imran",{"facility":90,"status":51,"city":91,"state":92,"zip":93,"country":55,"countryCode":56,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Phoenix Childrens Hospital","Phoenix","Arizona","85016",{"type":58,"coordinates":95},[96,97],-112.07404,33.44838,{"lat":97,"lon":96},[100,102],{"name":65,"role":66,"phone":101,"phoneExt":11,"email":11},"602-546-0920",{"name":103,"role":47,"phone":11,"phoneExt":11,"email":11},"Jessica Boklan",{"facility":105,"status":51,"city":106,"state":92,"zip":107,"country":55,"countryCode":56,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"The University of Arizona Medical Center-University Campus","Tucson","85724",{"type":58,"coordinates":109},[110,111],-110.92648,32.22174,{"lat":111,"lon":110},[114,116],{"name":65,"role":66,"phone":115,"phoneExt":11,"email":11},"520-626-9008",{"name":117,"role":47,"phone":11,"phoneExt":11,"email":11},"Yi Zeng",{"facility":119,"status":51,"city":120,"state":121,"zip":122,"country":55,"countryCode":56,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Arkansas Children's Hospital","Little Rock","Arkansas","72202-3591",{"type":58,"coordinates":124},[125,126],-92.28959,34.74648,{"lat":126,"lon":125},[129,130],{"name":65,"role":66,"phone":11,"phoneExt":11,"email":67},{"name":131,"role":47,"phone":11,"phoneExt":11,"email":11},"David L. 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