[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653052":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":29,"studyPopulation":30,"armGroups":31,"interventions":37,"overallOfficials":42,"centralContacts":46,"locations":56,"responsibleParty":77,"collaborators":79,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":25,"studyType":97,"phases":25,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":59,"whyStopped":25,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"University of North Carolina, Chapel Hill","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":25,"otherOutcomes":25},[9,13,16,19,22],{"measure":10,"description":11,"timeFrame":12},"Salivary Proteomic Profile","Unbiased and untargeted mass spectrometric analysis of saliva proteins to obtain a specific proteomic profile","During active infection through three months post infection",{"measure":14,"description":15,"timeFrame":12},"Salivary Metabolomic Profile","Unbiased and untargeted mass spectrometric analysis of saliva metabolites to obtain a specific metabolomic profile",{"measure":17,"description":18,"timeFrame":12},"Validated Health Questionnaires: SBQ-LC (Symptom Burden Questionnaire - Long COVID)","This instrument assesses PASC-related symptom burden following COVID-19 infection.\n\nScoring: 0- None, 1- Mild, 2- Moderate, 3-Severe - Higher score reflects greater severity.",{"measure":20,"description":21,"timeFrame":12},"Validated Health Questionnaire: C19-YRS (COVID-19 Yorkshire Rehabilitation Scale)","This instrument assesses the long-term physical, cognitive, and psychological outcomes following COVID-19 infection.\n\nScoring: 0-10 numerical scale; a higher score reflects greater severity.",{"measure":23,"description":24,"timeFrame":12},"Validated Health Questionnaire: EFTER-COVID survey","This instrument assesses the long-term physical, cognitive, and psychological outcomes following COVID-19 infection. EFTER is not an abbreviation; it is the name of the survey, and it is the Danish word for \"After\"\n\nScoring: Yes\u002FNo - Higher score reflects More affected.",null,{"allocation":25,"interventionModel":25,"interventionModelDescription":25,"primaryPurpose":25,"observationalModel":27,"timePerspective":28,"maskingInfo":25},"COHORT","PROSPECTIVE","Post-Acute Sequelae of COVID-19 (PASC), also known as Long COVID, is characterized by persistent or newly developed symptoms following SARS-CoV-2 infection. The biological mechanisms underlying persistent symptoms remain incompletely understood, particularly among individuals experiencing symptoms more than two years after infection.\n\nThis observational study will evaluate individuals with a history of SARS-CoV-2 infection to characterize the prevalence, severity, and persistence of PASC symptoms and identify demographic, clinical, and biological factors associated with these outcomes. Participants will complete questionnaires about their health and symptoms and provide saliva specimens for biological analyses.\n\nSaliva will be evaluated for biological factors that may be associated with persistent symptoms, including proteins, metabolites, microorganisms, and immune-related markers.\n\nMachine learning approaches will be used to integrate demographic, clinical, symptom, and saliva-based biological data to identify patterns associated with PASC. The study will evaluate whether these combined characteristics can be used to identify individuals who are more likely to experience persistent or severe symptoms following SARS-CoV-2 infection. The resulting models may help identify factors that contribute to Long COVID risk and inform future approaches for predicting persistent symptoms.\n\nThe study will include both newly enrolled participants and participants who previously participated in related SARS-CoV-2 research. Findings from this study may improve understanding of Long COVID and the factors associated with persistent symptoms following SARS-CoV-2 infection.","Adults aged 18 to 75 years with a history of SARS-CoV-2 infection will be enrolled. The study will include individuals with and without persistent symptoms following infection to characterize the prevalence, severity, and persistence of PASC and identify demographic, clinical, and biological factors associated with Long COVID. Approximately 500 participants will be enrolled at the University of North Carolina at Chapel Hill.",[32],{"label":33,"type":25,"description":34,"interventionNames":35},"COVID-19+","Adults who have previously had COVID-19 and may be experiencing ongoing symptoms or changes in their health following infection.",[36],"Other: This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms.",[38],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":25},"This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms.","Other:",[33],[43],{"name":44,"affiliation":5,"role":45},"Laura Jacox, PhD, DMD, MS","PRINCIPAL_INVESTIGATOR",[47,52],{"name":48,"role":49,"phone":50,"phoneExt":25,"email":51},"Laura A Jacox, PhD, DMD, MS","CONTACT","+1 847-702-0988","ljacox@live.unc.edu",{"name":53,"role":49,"phone":54,"phoneExt":25,"email":55},"Jeannene L Matthews, MA, M.Ed., CCC-SLP","+1 919-907-9685","jlab@unc.edu",[57],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"University of North Carolina","RECRUITING","Chapel Hill","North Carolina","27599-7555","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-79.05584,35.9132,{"lat":69,"lon":68},[72,73,76],{"name":48,"role":49,"phone":50,"phoneExt":25,"email":51},{"name":53,"role":49,"phone":74,"phoneExt":25,"email":75},"919-907-9685","jeannene_matthews@med.unc.edu",{"name":48,"role":45,"phone":25,"phoneExt":25,"email":25},{"type":78,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[80],{"name":81,"class":82},"National Institute of Dental and Craniofacial Research (NIDCR)","NIH","100653052","long-term-study-of-covid-19-infection-and-long-covid-100653052",false,"NCT07781501","Long-Term Study of COVID-19 Infection and Long COVID","Longitudinal Study of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Post-Acute Sequelae of COVID-19 (PASC)","PASC","Inclusion Criteria:\n\n* Age 18 to 75 years.\n* Previous laboratory-confirmed SARS-CoV-2 infection.\n* Willing and able to provide informed consent.\n* Able to complete study questionnaires and study procedures.\n\nExclusion Criteria:\n\n* Current severe periodontal disease with bleeding gums.\n* Current oral herpes flare, aphthous ulcer, or oral candidiasis (thrush).\n* Oral viral or bacterial infection within the previous 30 days.\n* Dry mouth that would prevent adequate saliva collection.\n* Active alcohol or drug abuse.\n* Medical or genetic syndrome or developmental delay that would prevent completion of study procedures or questionnaires.","ALL","18 Years","75 Years",{"count":95,"type":96},500,"ESTIMATED","OBSERVATIONAL","This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19. Researchers will collect information about participants' health and symptoms through questionnaires and may collect saliva and other non-invasive oral samples. The study will also examine biological factors in these samples that may be associated with persistent symptoms. The goal is to better understand why some people develop Long COVID and identify factors that may help predict who is more likely to experience persistent symptoms.",[100],"SARS CoV-2 Post-Acute Sequelae",[102,103,104],"COVID-19","SARS-CoV-2","Long COVID","2026-09-24",{"date":107,"type":108},"2026-09-28","ACTUAL",{"date":110,"type":108},"2024-09-04",{"date":112,"type":96},"2029-12-31",{"name":5,"class":6},1]