[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649880":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":37,"responsibleParty":54,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":88,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Low-Intensity Extracorporeal Shock Wave Therapy","EXPERIMENTAL","Participants will receive active low-intensity extracorporeal shock wave therapy using the PiezoWave 2 focused extracorporeal shock wave therapy device. Treatment will be administered once weekly for 6 weeks. Before each session, participants will drink 1000 mL of water, and treatment will begin when the bladder reaches approximately 50% of the participant's functional bladder capacity, confirmed by bladder scan. The probe will be placed over the lower abdomen approximately two fingerbreadths above the pubic symphysis and directed toward the bladder dome and bilateral bladder walls. Each session will deliver 1000 impulses to each target area, for a total of 3000 impulses, at an energy density of 0.25 mJ\u002Fmm² and a frequency of 3 pulses per second.",[13],"Device: Low-Intensity Extracorporeal Shock Wave Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Low-Intensity Extracorporeal Shock Wave Therapy","SHAM_COMPARATOR","Participants will receive a sham procedure once weekly for 6 weeks. The procedure will be similar to the active treatment in participant positioning, bladder preparation, probe placement, session duration, and device sound. A sham probe or zero-energy device setting will be used so that no therapeutic shock wave energy is delivered.",[19],"Device: Sham Low-Intensity Extracorporeal Shock Wave Therapy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Low-Intensity Extracorporeal Shock Wave Therapy","Focused low-intensity extracorporeal shock wave therapy will be delivered using the PiezoWave 2 device. Each session will deliver a total of 3000 impulses at an energy density of 0.25 mJ\u002Fmm² and a frequency of 3 pulses per second. Treatment will be administered once weekly for 6 weeks.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"A sham procedure will be administered using the same treatment setup, participant positioning, probe placement, session duration, and device sound as active therapy. A sham probe or zero-energy setting will be used so that no therapeutic shock wave energy is delivered. The procedure will be performed once weekly for 6 weeks.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Abdelrahman F Senosy, MBBCh","CONTACT","010 95324741","+02","Abdelrahmanadam96@gmail.com",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Ain Shams University Hospital","Cairo","Cairo Governorate","11511","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.24967,30.06263,{"lat":49,"lon":48},[52],{"name":32,"role":33,"phone":34,"phoneExt":53,"email":36},"+2",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Abdelrahman Farid Adam Senosy","Resident of Urology","100649880","low-intensity-shock-wave-therapy-for-refractory-overactive-bladder-in-women-100649880",false,"NCT07739550","Low-Intensity Shock Wave Therapy for Refractory Overactive Bladder in Women","Therapeutic Effects of Low-Intensity Extracorporeal Shock Wave Therapy on Refractory Overactive Bladder Symptoms in Females","Inclusion Criteria:\n\n* Female participants aged 18 to 70 years.\n* Symptoms of overactive bladder with an Overactive Bladder Questionnaire 8-Item total score greater than 8.\n* Failure of behavioral therapy and medical treatment for overactive bladder.\n* Refusal of medical treatment for overactive bladder. Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Current use of medical treatment for overactive bladder.\n* Cardiac pacemaker or metallic implant in the treatment area.\n* Coagulation disorder or use of anticoagulants that cannot be temporarily discontinued.\n* Active urinary tract infection; participants may be reconsidered after successful treatment and recovery.\n* Urinary bladder stones.\n* Post-void residual urine volume greater than 100 mL.\n* Lower urinary tract surgery within the previous 6 months.\n* Previous pelvic radiation therapy.\n* History of neuropathic disease.\n* Pregnancy or planning to become pregnant.\n* Hepatic, renal, or cardiac impairment.","FEMALE","18 Years","70 Years",{"count":69,"type":70},40,"ESTIMATED","INTERVENTIONAL",[73],"NA","Overactive bladder is a condition characterized by a sudden and difficult-to-control need to urinate, which may occur with frequent urination, nighttime urination, and urine leakage. Some women continue to experience these symptoms despite lifestyle changes, behavioral therapy, and medication, or they cannot tolerate or decline medical treatment.\n\nThis study will evaluate whether low-intensity extracorporeal shock wave therapy (Li-ESWT), a non-surgical treatment delivered externally over the lower abdomen, can safely improve refractory overactive bladder symptoms in women.\n\nA total of 40 women will be randomly assigned in equal numbers to receive either active Li-ESWT or a sham treatment. Both groups will attend one treatment session each week for six weeks. The sham procedure will be similar to the active treatment in positioning, session duration, and device sound but will not deliver shock wave energy.\n\nSymptoms will be assessed using the validated Arabic version of the 8-item Overactive Bladder Questionnaire (OAB-V8) before treatment and during follow-up. The main purpose of the study is to compare the change in OAB-V8 symptom score between the two groups after one month. Additional assessments at three months will include post-void residual urine volume, information from a 3-day voiding diary, the participant's overall impression of improvement, and any treatment-related adverse events.\n\nThe study hypothesis is that Li-ESWT will improve overactive bladder symptoms and quality of life compared with sham treatment.",[76],"Urinary Bladder, Overactive",[78,23,79,80,81,82,83,84,85,86,87],"Refractory Overactive Bladder","Female Lower Urinary Tract Symptoms","Urinary Urgency","Urinary Frequency","Nocturia","Urgency Urinary Incontinence","Functional Bladder Capacity","Post-Void Residual Urine","Sham-Controlled Clinical Trial","Overactive Bladder Questionnaire, 8-Item","NOT_YET_RECRUITING","2026-07-28",{"date":91,"type":92},"2026-07-31","ACTUAL",{"date":94,"type":70},"2026-08-01",{"date":96,"type":70},"2027-02-01",{"name":5,"class":6},1]