[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657449":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":25,"studyPopulation":25,"armGroups":32,"interventions":39,"overallOfficials":45,"centralContacts":49,"locations":59,"responsibleParty":75,"collaborators":25,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":25,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":25,"studyType":91,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Mayo Clinic","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":25,"otherOutcomes":25},[9,13,16,19,22],{"measure":10,"description":11,"timeFrame":12},"Arterial Oxygen Saturation During Lower Body Negative Pressure","Arterial oxygen saturation will be measured during lower body negative pressure using noninvasive physiological monitors","During the single study visit, from baseline through completion of the lower body negative pressure protocol, up to 40 minutes",{"measure":14,"description":15,"timeFrame":12},"ECG Waveform During Lower Body Negative Pressure","ECG waveform will be measured during lower body negative pressure using noninvasive physiological monitor",{"measure":17,"description":18,"timeFrame":12},"Respiratory Rate During Lower Body Negative Pressure","Respiratory rate will be measured during lower body negative pressure using noninvasive physiological monitors",{"measure":20,"description":21,"timeFrame":12},"Plethysmography Signals During Lower Body Negative Pressure via physiological monitors","Plethysmography signals will be measured during lower body negative pressure from the pulse oximetry. Reported as a non-invasive research metric of central blood volume.",{"measure":23,"description":24,"timeFrame":12},"Heart rate During Lower Body Negative Pressure","Heart rate will be measured during lower body negative pressure using noninvasive physiological monitors",null,{"allocation":27,"interventionModel":28,"interventionModelDescription":25,"primaryPurpose":29,"observationalModel":25,"timePerspective":25,"maskingInfo":30},"NA","SINGLE_GROUP","BASIC_SCIENCE",{"masking":31,"maskingDescription":25,"whoMasked":25},"NONE",[33],{"label":34,"type":35,"description":36,"interventionNames":37},"Healthy Volunteers Undergoing Lower Body Negative Pressure","EXPERIMENTAL","Healthy adult participants will complete one study visit involving graded lower body negative pressure while standard physiological reference measurements and noninvasive investigational physiological monitor data are collected.",[38],"Diagnostic Test: Lower Body Negative Pressure with Noninvasive Physiological Monitoring",[40],{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":25},"DIAGNOSTIC_TEST","Lower Body Negative Pressure with Noninvasive Physiological Monitoring","Participants will undergo a graded lower body negative pressure protocol using suction levels of 15, 30, 45, 60, 70, 80, 90, and 100 mmHg, each for up to 5 minutes or until presyncopal symptoms or other termination criteria occur. During the procedure, validated reference physiological measurements and investigational noninvasive monitor signals will be collected simultaneously.",[34],[46],{"name":47,"affiliation":5,"role":48},"Michael J. Joyner, MD","PRINCIPAL_INVESTIGATOR",[50,55],{"name":51,"role":52,"phone":53,"phoneExt":25,"email":54},"Pamela Engrav","CONTACT","507-255-6938","engrav.pamela@mayo.edu",{"name":56,"role":52,"phone":57,"phoneExt":25,"email":58},"Ronee Harvey","507-255-1466","harvey.ronee@mayo.edu",[60],{"facility":5,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":68,"coordinates":69},"Point",[70,71],-92.4699,44.02163,{"lat":71,"lon":70},[74],{"name":51,"role":52,"phone":53,"phoneExt":25,"email":25},{"type":48,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Michael J. Joyner, M.D.","Principal Investigator","100657449","lower-body-negative-pressure-to-validate-physiological-monitors-100657449",false,"NCT07840144","Lower Body Negative Pressure to Validate Physiological Monitors","Inclusion Criteria:\n\n* Non-obese (BMI\\\u003C30)\n* Non-smokers\n* Free of any systemic diseases including hypertension, diabetes, coronary artery disease, neurologic disease, or any other major medical co-morbidity.\n* Women will be either surgically sterilized or non-pregnant as determined by a urine pregnancy test (within 48 hours of the study day)\n\nExclusion Criteria:\n\n* Individuals taking GLP-1 medications or compounds known to affect responses of the autonomic nervous system to orthostatic stress (e.g., β-blockers)\n* Pregnant women",true,"ALL","18 Years","55 Years",{"count":89,"type":90},50,"ESTIMATED","INTERVENTIONAL",[27],"The purpose of this research is to test the accuracy of non-invasive physiological monitors while the body responds to different levels of lower body negative pressure (LBNP).",[95],"Physiological Stress",[97],"Hemodynamic Monitoring","2026-09-21",{"date":100,"type":101},"2026-09-24","ACTUAL",{"date":103,"type":90},"2026-09-30",{"date":105,"type":90},"2028-09-28",{"name":5,"class":6},1]