[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646261":3},{"organization":4,"outcomesModule":7,"designInfo":38,"detailedDescription":37,"studyPopulation":37,"armGroups":44,"interventions":57,"overallOfficials":37,"centralContacts":67,"locations":37,"responsibleParty":73,"collaborators":37,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":37,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":37,"enrollmentInfo":86,"targetDuration":37,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":102,"whyStopped":37,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":37},{"fullName":5,"class":6},"The New England Baptist Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":37},[9],{"measure":10,"description":11,"timeFrame":12},"Numeric Rating Scale on Pain Level","Range: 0-10 Higher score means more painful.","4 months post-treatment",[14,16,20,24,26,27,29,31,32,34,36],{"measure":10,"description":11,"timeFrame":15},"1 month post-treatment",{"measure":17,"description":18,"timeFrame":19},"Oswestry Disability Index","Range: 0-100% Higher score means greater disability.","1 Month post-procedure",{"measure":21,"description":22,"timeFrame":23},"Patient Global Impression of Change","7-point Likert scale\n\n1 = very much improved, 7 = very much worse","1 month post-procedure",{"measure":17,"description":18,"timeFrame":25},"4 months post-procedure",{"measure":21,"description":22,"timeFrame":25},{"measure":10,"description":11,"timeFrame":28},"6 months post-treatment",{"measure":17,"description":18,"timeFrame":30},"6 months post-procedure",{"measure":21,"description":22,"timeFrame":30},{"measure":10,"description":11,"timeFrame":33},"12 months post-treatment",{"measure":17,"description":18,"timeFrame":35},"12 months post-procedure",{"measure":21,"description":22,"timeFrame":35},null,{"allocation":39,"interventionModel":40,"interventionModelDescription":37,"primaryPurpose":41,"observationalModel":37,"timePerspective":37,"maskingInfo":42},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":43,"maskingDescription":37,"whoMasked":37},"NONE",[45,51],{"label":46,"type":47,"description":48,"interventionNames":49},"Platelet-Rich-Plasma Injection","EXPERIMENTAL","Participants will receive fluoroscopically guided intra-periarticular lumbar facet platelet-rich plasma (PRP) injection for the treatment of chronic lumbar facet-mediated pain.",[50],"Procedure: Platelet Rich Plasma Joint Injection",{"label":52,"type":53,"description":54,"interventionNames":55},"Radiofrequency Ablation","ACTIVE_COMPARATOR","Participants will undergo lumbar medial branch radiofrequency ablation (RFA) for the treatment of chronic lumbar facet-mediated pain.",[56],"Procedure: Medial branch radiofrequency ablation",[58,63],{"type":59,"name":60,"description":61,"armGroupLabels":62,"otherNames":37},"PROCEDURE","Platelet Rich Plasma Joint Injection","Autologous platelet-rich plasma (PRP) will be prepared using the Arthrex ACP double-syringe system according to manufacturer instructions. PRP will be injected into the lumbar facet joint and\u002For periarticular region under fluoroscopic guidance using sterile technique.",[46],{"type":59,"name":64,"description":65,"armGroupLabels":66,"otherNames":37},"Medial branch radiofrequency ablation","Lumbar medial branch radiofrequency ablation will be performed under fluoroscopic guidance using standard thermal radiofrequency lesioning techniques targeting the medial branch nerves supplying the symptomatic lumbar facet joints.",[52],[68],{"name":69,"role":70,"phone":71,"phoneExt":37,"email":72},"Ruijia Niu","CONTACT","617-754-6732","research@nebh.org",{"type":74,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"PRINCIPAL_INVESTIGATOR","Andrew Lederman","Chief of Physiatry and Interventional Pain Physician","100646261","lumbar-facet-platelet-rich-plasma-injection-versus-medial-branch-radiofrequency-ablation-for-chronic-lumbar-facet-mediated-pain-100646261",false,"NCT07692737","Lumbar Facet Platelet-Rich Plasma Injection Versus Medial Branch Radiofrequency Ablation for Chronic Lumbar Facet-Mediated Pain","A Randomized Controlled Trial Comparing Intra-Periarticular Lumbar Facet Platelet-Rich Plasma Injection Versus Medial Branch Radiofrequency Ablation for Chronic Lumbar Facet-Mediated Pain","Inclusion Criteria:\n\n* Adults with chronic lumbar back pain suspected to be facet-mediated\n* ≥80% pain relief following two diagnostic medial branch blocks\n* Ability to provide informed consent\n* Ability to complete patient-reported outcome measures\n\nExclusion Criteria:\n\n* Active radiculopathy or alternate dominant spinal pain generator\n* Prior lumbar fusion at target level\n* Active systemic infection or local infection at injection site\n* Thrombocytopenia, less than 100,000\u002FuL\n* Anemia, Hemoglobin less than 10 g\u002FdL\n* Pregnancy\n* Inability to complete follow-up assessments","ALL","18 Years",{"count":87,"type":88},30,"ESTIMATED","INTERVENTIONAL",[91],"NA","The first clinical research effort under this initiative is a pilot randomized controlled trial comparing intra-periarticular lumbar facet platelet-rich plasma (PRP) injection to standard-of-care medial branch radiofrequency ablation (RFA) for chronic lumbar facet-mediated pain.\n\nThe study is designed to:\n\n* Use contemporary best-practice techniques for both treatment arms\n* Minimize incremental risk beyond standard care\n* Generate feasibility, safety, and preliminary comparative effectiveness data\n* Inform future definitive trials and potential program expansion",[94,95],"Chronic Lower Back Pain (CLBP)","Lumbar Facet Joint Pain",[97,98,52,99,100,101],"Platelet-Rich Plasma","PRP","Lumbar Facet Joint","Medial Branch Neurotomy","Spine Injection","NOT_YET_RECRUITING","2026-07-07",{"date":105,"type":106},"2026-07-09","ACTUAL",{"date":108,"type":88},"2026-06",{"date":110,"type":88},"2028-06",{"name":5,"class":6}]