[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652878":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":11,"centralContacts":26,"locations":32,"responsibleParty":44,"collaborators":46,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":11,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":76,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"National University Hospital, Singapore","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Individualized, resting-state functional connectivity-guided accelerated iTBS","EXPERIMENTAL",null,[13,14],"Device: Individualized resting-state functional connectivity-guided iTBS","Diagnostic Test: Symptom-titrated algorithm-based longitudinal ECT (STABLE) algorithm",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":11},"DEVICE","Individualized resting-state functional connectivity-guided iTBS","MagPro X100, Axilium Cobot, Localite Camera",[9],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"DIAGNOSTIC_TEST","Symptom-titrated algorithm-based longitudinal ECT (STABLE) algorithm","The STABLE relapse detection algorithm provides a symptom-driven retreatment scheduling. It is validated to prolong TRD response to electroconvulsive therapy (ECT) while minimizing overtreatment. The algorithm will be adapted for TMS and will be used to determine the need for maintenance iTBS treatment.",[9],[27],{"name":28,"role":29,"phone":30,"phoneExt":11,"email":31},"Phern Chern Tor, MBBS","CONTACT","+65 6908 2222","cip@nuhs.edu.sg",[33],{"facility":5,"status":11,"city":34,"state":11,"zip":11,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Singapore","SG",{"type":37,"coordinates":38},"Point",[39,40],103.85007,1.28967,{"lat":40,"lon":39},[43],{"name":28,"role":29,"phone":30,"phoneExt":11,"email":31},{"type":45,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[47],{"name":48,"class":6},"National University of Singapore","100652878","maintenance-individualized-neuromodulation-and-depression-detection-via-sensors-for-early-treatment-100652878",false,"NCT07779330","Maintenance Individualized Neuromodulation and Depression-detection Via Sensors for Early Treatment","MINDSET: Maintenance Individualized Neuromodulation and Depression-detection Via Sensors for Early Treatment","MINDSET","Inclusion Criteria:\n\n* Male\u002F female aged ≥ 21 to ≤ 70 years old\n* Able to give informed consent\n* Able to understand English\n* DSM-V diagnosis of current\u002F past major depressive disorder (MDD) episode\n* Non-response to an adequate trial (4 weeks) of at least 1 MDD medication as verified by a study clinician\n* Ability to comply with passive wearable use and weekly mobile assessments\n* Have previously completed a course of individualized, functional connectivity-guided accelerated iTBS and shown a clinical response (as defined by a ≥50% improvement in MADRS score against baseline, any time within 3 months following an acute iTBS course)\n* Able to comply with the full 12-month protocol inclusive of continuous digital monitoring\n\nExclusion Criteria:\n\n* DSM-5 psychotic disorder\n* Drug or alcohol abuse or dependence (preceding 3 months)\n* Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy\n* Metal in the cranium, skull defects, pacemaker, cochlear implant, medication infusion pump or any other electronic implants or devices\n* Tattoos containing ferromagnetic ink or permanent piercings\n* Pregnancy\n* Currently on multiple CNS stimulant medications (2 or more at maximal clinical doses)\n* Participant does not have the capacity to provide consent","ALL","21 Years","70 Years",{"count":61,"type":62},24,"ESTIMATED","INTERVENTIONAL",[65],"NA","This proposal seeks to carry out a prospective, single-arm open label study aimed at sustaining treatment-resistant depression (TRD) response in patients with TRD who had responded to prior individualized resting-state functional connectivity (rs-FC)-guided intermittent theta burst stimulation (iTBS). It also seeks to detect and predict relapse risk by integrating rs-FC iTBS with a TMS-adapted needs-based symptom-titrated algorithm based longitudinal ECT (STABLE) maintenance scheduling algorithm, and passive digital biomarkers.",[68],"Depression Disorder",[70,71,72,73,74,75],"Depression","iTBS","Neuronavigated","Maintenance","Relapse","Treatment resistant depression","NOT_YET_RECRUITING","2026-08-18",{"date":79,"type":80},"2026-08-21","ACTUAL",{"date":82,"type":62},"2026-09",{"date":84,"type":62},"2029-12",{"name":5,"class":6},1]