[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563618":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":55,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":25,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":25,"overallStatus":75,"whyStopped":25,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Manual debridement","ACTIVE_COMPARATOR","Manual debridement is a technique that has existed since 1952 and whose objective is to remove the irregular epithelium by scraping with an instrument, thus allowing the formation of a new superficial layer. Some surgeons use 20% ethanol which they apply to the cornea to debride it before using a blade or sponge to complete the procedure. In this technique, the basement membrane is preserved. This method is still used being simple and cost effective. Its effectiveness in the treatment of recurrent corneal erosions is demonstrated by a success rate estimated at 85%. Thus, it is one of the methods of treating epithelial basement membrane dystrophy. However, the recurrence rate associated with manual debridement is up to 24%, and the average duration before a first recurrence is estimated at 6 months. The formation of corneal opacities was recorded between 7 and 41 days following the intervention.",[13],"Procedure: Manual debridement",{"label":15,"type":16,"description":17,"interventionNames":18},"Phototherapeutic keratectomy","EXPERIMENTAL","Over the past two decades, phototherapeutic keratectomy (PTK) has become an increasingly used approach for the treatment of several anterior corneal pathologies, including epithelial basement membrane dystrophy. This technique consists of directing a 193nm excimer laser towards the epithelial surface in order to break the molecular bonds between cells. PTK appears to be a more reliable, safe and precise alternative to manual debridement. Unlike manual debridement, PTK completely obliterates the basement membrane which would promote a reduction in the recurrence rate according to some experts. Thus, the success rate without recurrence has been estimated between 46 to 100% by certain studies and the associated complications are minimal.",[19],"Procedure: Phototherapeutic keratectomy",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Traditional technique which consists of scraping off the irregular epithelium to allow a new layer to form.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"New technique which has been increasingly used and which consists of a 193nm excimer laser that breaks molecular bonds between cells on the epithelial surface.",[15],[30],{"name":31,"affiliation":5,"role":32},"Samir Jabbour, MD,CM,FRCSC","PRINCIPAL_INVESTIGATOR",[34,39],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","514-890-8000","11550","Samir.Jabbour.med@ssss.gouv.qc.ca",{"name":40,"role":35,"phone":36,"phoneExt":37,"email":41},"Marie-Catherine Tessier, M.Sc.","marie-catherine.tessier.chum@ssss.gouv.qc.ca",[43],{"facility":5,"status":25,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":25},"Montreal","Quebec","H2X 3E4","Canada","CA",{"type":50,"coordinates":51},"Point",[52,53],-73.58781,45.50884,{"lat":53,"lon":52},{"type":56,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100563618","manual-debridement-vs-phototherapeutic-keratectomy-in-the-treatment-of-corneal-basement-membrane-dystrophy-100563618",false,"NCT06618508","Manual Debridement vs Phototherapeutic Keratectomy in the Treatment of Corneal Basement Membrane Dystrophy","Comparison of Efficacy and Safety Between Manual Debridement and Phototherapeutic Keratectomy (PTK) in the Treatment of Corneal Basement Membrane Dystrophy","Inclusion Criteria:\n\n* Patient over 18 years of age;\n* Ability to give free and informed consent\n* At least 1-year follow-up possible\n* Patients with bilateral basal membrane corneal dystrophy who are symptomatic (recurrent corneal erosions, visual disturbances) and are candidates for bilateral surgery.\n\nExclusion Criteria:\n\n* Patient under 18 years of age;\n* History of ocular infection with herpes simplex virus.","ALL","18 Years",{"count":67,"type":68},25,"ESTIMATED","INTERVENTIONAL",[71],"NA","Of the few comparisons made in the existing literature, the results of PTK are comparable to those documented for manual debridement (MD). However, the shorter length of follow-up in patients with MD may have underestimated the associated complications. Our study, therefore, aims to offer a comparison between these two techniques to clarify the choice of effective treatment with a good safety profile.",[74],"Epithelial Basement Membrane Dystrophy","NOT_YET_RECRUITING","2026-07-06",{"date":78,"type":79},"2026-07-08","ACTUAL",{"date":81,"type":68},"2026-10",{"date":83,"type":68},"2027-10",{"name":5,"class":6},1]