[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651724":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":43,"collaborators":45,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":24,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":74,"whyStopped":24,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"National University Hospital, Singapore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dysphoric target","EXPERIMENTAL","Participants will receive individualized connectome-guided accelerated iTBS at their dysphoric target.\n\nParticipants will receive an accelerated iTBS treatment delivered with a MagVenture MagPro X100 system (MagVenture A\u002FS, Denmark) equipped with a butterflu shaped MagVenture Cool-B65 A\u002FP coil. The treatment course is comprised of 6 treatment sessions daily for 5 consecutive workdays for a total of 30 sessions. Each iTBS session is approximately 10 minutes (depth corrected Resting Motor Threshold of 90%, 60 cycles of 10 bursts of three pulses at 50Hz, repeated at 5Hz; 2s on and 8s off; 1800 puolses per session; with a 50-minute interval between sessions). All iTBS sessions will be performed by staff trained and credentialed in TMS according to Singapore College of Psychiatrists guidelines.",[13],"Device: Individualized connectome-guided accelerated iTBS",{"label":15,"type":10,"description":16,"interventionNames":17},"Anxiosomatic target","Participants will receive individualized connectome-guided accelerated iTBS at their anxiosomatic target.\n\nParticipants will receive an accelerated iTBS treatment delivered with a MagVenture MagPro X100 system (MagVenture A\u002FS, Denmark) equipped with a butterflu shaped MagVenture Cool-B65 A\u002FP coil. The treatment course is comprised of 6 treatment sessions daily for 5 consecutive workdays for a total of 30 sessions. Each iTBS session is approximately 10 minutes (depth corrected Resting Motor Threshold of 90%, 60 cycles of 10 bursts of three pulses at 50Hz, repeated at 5Hz; 2s on and 8s off; 1800 puolses per session; with a 50-minute interval between sessions). All iTBS sessions will be performed by staff trained and credentialed in TMS according to Singapore College of Psychiatrists guidelines.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Individualized connectome-guided accelerated iTBS","Magpro X100, Axilium Cobot, Localite Camera",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Phern Chern Tor, MBBS","CONTACT","+65 6908 2222","cip@nuhs.edu.sg",[32],{"facility":5,"status":24,"city":33,"state":24,"zip":24,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Singapore","SG",{"type":36,"coordinates":37},"Point",[38,39],103.85007,1.28967,{"lat":39,"lon":38},[42],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},{"type":44,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[46],{"name":47,"class":6},"National University of Singapore","100651724","mapping-the-neural-circuits-of-depression-and-anxiety-using-personalized-accelerated-tms-and-deep-phenotyping-100651724",false,"NCT07766291","Mapping the Neural Circuits of Depression and Anxiety Using Personalized, Accelerated TMS and Deep Phenotyping","ADAPT","Inclusion Criteria:\n\n* Male\u002Ffemale aged 21-70\n* Diagnosis of MDD as validated by MINI\n* Non-response to adequate trial (4 weeks) of at least two MDD medication as verified by the study clinician\n* BDI score of 20 or above; BAI score of 16 or above\n* Able to give informed consent\n* Able to understand English\n\nExclusion Criteria:\n\n* DSM-5 psychotic disorder\n* Drug or alcohol abuse or dependence (preceding 3 months)\n* Rapid clinical response required, e.g., high suicide risk\n* Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy\n* Metal in the cranium, skull defects, pacemaker, cochlear implant, medication pump or other electronic device\n* Pregnancy\n* Unsuitable for MRI\n* With recent TMS or ECT treatment in past 3 months\n* Multiple stimulant medications","ALL","21 Years","70 Years",{"count":59,"type":60},36,"ESTIMATED","INTERVENTIONAL",[63],"NA","This proposal seeks to carry out a double-blinded, randomized, comparative study that investigates neurobehavioral changes induced by personalized, anxiosomatic and dysphoric network guided accelerated intermittent-theta burst (iTBS) using dense functional Magnetic Resonance Imaging (fMRI) sampling in participants with treatment-resistant depression (TRD) and moderate\u002Fhigh levels of anxiety.",[66],"Depression Disorder",[68,69,70,71,72,73],"Depression","Neuronavigated","iTBS","RCT","Accelerated","Anxiety","NOT_YET_RECRUITING","2026-08-13",{"date":77,"type":78},"2026-08-14","ACTUAL",{"date":80,"type":60},"2026-09-01",{"date":82,"type":60},"2029-12-31",{"name":5,"class":6},1]