[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623534":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":51,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Saglik Bilimleri Universitesi","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Peri-implantitis Group",null,"Patients with at least one dental implant in function for at least 1 year, showing signs of inflammation (BOP\u002Fsuppuration), probing depth (PD) ≥ 5 mm, and radiographic bone loss ≥ 2 mm.",{"label":13,"type":10,"description":14,"interventionNames":10},"Periodontitis Group","Patients with at least one tooth having clinical probing depth ≥ 4 mm, presence of bleeding on probing (BOP), and evidence of radiographic alveolar bone loss.",{"label":16,"type":10,"description":17,"interventionNames":10},"Peri-implant Health Group","Patients with implants in function for at least 1 year, showing no signs of inflammation (no BOP), probing depth ≤ 3 mm, and no radiographic bone loss.",{"label":19,"type":10,"description":20,"interventionNames":10},"Periodontal Health Group","Systemically healthy individuals with clinical probing depths ≤ 3 mm, minimal plaque and bleeding scores, and no radiographic evidence of bone loss.",[22],{"name":23,"affiliation":24,"role":25},"Gülbahar Ustaoğlu, Professor","University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Nurullah Yurdakul, Dr.","CONTACT","+905340757662","nurullah.yurdakul@sbu.edu.tr",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":10,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Gülhane Faculty of Dentistry, University of Health Sciences","RECRUITING","Keçiören","Ankara","06010","Turkey (Türkiye)",{"type":41,"coordinates":42},"Point",[43,44],32.87238,40.00132,{"lat":44,"lon":43},[47],{"name":48,"role":29,"phone":49,"phoneExt":10,"email":50},"Nurullah Yurdakul","05340757662","yurdakul.nurullah@gmail.com",{"type":25,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Gülbahar Ustaoğlu","Professor","100623534","markers-of-bone-destruction-and-oxidative-stress-in-peri-implantitis-100623534",false,"NCT07397884","Markers of Bone Destruction and Oxidative Stress in Peri-implantitis","Evaluation of Bone Destruction and Oxidative Stress Markers in Saliva and Peri-implant Sulcus Fluid in Peri-implantitis","Inclusion Criteria:\n\nSystemically healthy volunteers aged 18-65. For Peri-implantitis group: Implants in function for ≥1 year, radiographic bone loss ≥ 2 mm, probing depth (PD) ≥ 5 mm, and presence of bleeding on probing (BOP) or suppuration.\n\nFor Periodontitis group: At least one tooth with PD ≥ 4 mm, presence of BOP, and radiographic bone loss.For Healthy groups: PD ≤ 3 mm, no clinical inflammation (BOP-), and no radiographic bone loss.\n\n(According to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases) -\n\nExclusion Criteria:Presence of systemic diseases (e.g., diabetes, rheumatoid arthritis, osteoporosis).\n\nUse of antibiotics, anti-inflammatory, or immunosuppressive drugs within the last 3 months.\n\nPregnancy or breastfeeding.\n\nSmoking (current smokers).\n\nHistory of periodontal or peri-implant surgical treatment within the last 6 months.\n\nImplant failure (mobility).\n\nSigns of acute infection (fever, systemic symptoms).\n\n\\-",true,"ALL","18 Years","65 Years",{"count":66,"type":67},80,"ESTIMATED","OBSERVATIONAL","The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.",[71,72],"Periodontal Diseases","Periimplant Diseases",[71,74,75,76],"periimplant diseases","Oxidative Stress","Alveolar Bone Loss","2026-08-10",{"date":79,"type":80},"2026-08-11","ACTUAL",{"date":82,"type":80},"2026-02-15",{"date":84,"type":67},"2026-09-15",{"name":5,"class":6},1]