[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551356":3},{"organization":4,"outcomesModule":7,"designInfo":36,"detailedDescription":39,"studyPopulation":40,"armGroups":41,"interventions":46,"overallOfficials":51,"centralContacts":56,"locations":65,"responsibleParty":561,"collaborators":563,"id":598,"slug":599,"hasResults":600,"nctId":601,"briefTitle":602,"officialTitle":603,"acronym":604,"eligibilityCriteria":605,"healthyVolunteers":600,"sex":606,"minAge":607,"maxAge":35,"enrollmentInfo":608,"targetDuration":35,"studyType":611,"phases":35,"briefSummary":612,"conditions":613,"keywords":616,"overallStatus":68,"whyStopped":35,"lastUpdateSubmitDate":621,"lastUpdatePostDateStruct":622,"startDateStruct":625,"completionDateStruct":627,"leadSponsor":629,"locationsCount":630},{"fullName":5,"class":6},"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":35},[9],{"measure":10,"description":11,"timeFrame":12},"The primary endpoint is to determine the overall survival of R\u002FR AML patients","Overall survival is defined as the time from R\u002FR diagnosis to death due to any cause.","8 years",[14,17,20,23,26,29,32],{"measure":15,"description":16,"timeFrame":12},"Remission rate","Response is defined according to ELN 2022 criteria. Rates of CR, CRi, CRh and overall response (CR+CRi+CRh) as best response will be considered",{"measure":18,"description":19,"timeFrame":12},"Event-free survival","Event-free survival is defined as the time from R\u002FR diagnosis to rescue treatment failure (according to ELN 2022 definitions), relapse or death due to any cause, whichever occurs first.",{"measure":21,"description":22,"timeFrame":12},"Relapse free survival","Relapse-free survival is defined for patients achieving a response to rescue treatment as the time from response onset to relapse or death due to any cause, whichever occurs first.",{"measure":24,"description":25,"timeFrame":12},"Transplant rate","Proportion of patients undergoing transplantation",{"measure":27,"description":28,"timeFrame":12},"Describe the methods for diagnosis and the treatment options offered to the patients affected by R\u002FR AML","type and frequency of diagnostic procedures used and treatments prescribed",{"measure":30,"description":31,"timeFrame":12},"Association between baseline clinical, molecular and biological parameters and clinical outcomes","Rates of CR, CRi, CRh and overall response (CR+CRi+CRh) in specific sub-populations bearing common molecular features",{"measure":33,"description":34,"timeFrame":12},"To characterize potential populations that could be target for future studies\u002Fclinical trials","descriptive statistics (mean, median, frequency, range) of subpopulations characteristics",null,{"allocation":35,"interventionModel":35,"interventionModelDescription":35,"primaryPurpose":35,"observationalModel":37,"timePerspective":38,"maskingInfo":35},"COHORT","PROSPECTIVE","Treatment outcome for acute myeloid leukemia (AML) has improved over the last few decades. With intensive multidrug induction regimens, a complete remission is expected. Despite such advances, therapy resistance or relapse remains the main causes of death in adult patients and in children. Relapsed or refractory (R\u002FR) AML is a hard-to-treat disease, with a 5-year overall survival (OS) estimate below 20% in adults and 30%-35% in children, and no standard of care exists. HSCT (allogeneic hematopoietic stem cell transplantation) remains the only curative strategy for R\u002FR AML patients, including pediatric and elderly ones. Some new personalized therapies have recently been integrated into the treatment options of R\u002FR AML. However, there is a need to collect consistent data on the efficacy of these new strategies in real-world settings. Lack of data from clinical trials can be a barrier in most countries, limiting patient accessibility to some very effective drugs. The STREAM study is part of the Horizon Europe Mission Cancer 2022 IMPACT-AML project, that proposes to create an inclusive master framework for relapsed or refractory acute myeloid leukemia. In STREAM we will collect data and monitor outcomes of patients with R\u002FR AML across Europe. In close collaboration with the European Reference Network on Rare Hematological Diseases (ERN-EuroBloodNet, GA101157011), STREAM is developed under ERN-EuroBloodNet central registry, the European Rare Blood Disorders Platform (ENROL), incorporating EU standards for interoperability and the GPDR-compliant SPIDER pseudonymization tool offered by the EU-RD Platform in the context of rare disease registries will be implemented, to allow cross-hospital and cross-country participation. The STREAM study will allow to collect high-quality data from patients at any stage of the disease, for any cancer subtype, in any age group, including pediatric and elderly population, unfit patients, patients with rare mutations, patients with high-impact end-organ damage, patients from rural regions, post-transplant relapse. Data collected in STREAM will foster the production of novel knowledge on rare populations in a pragmatic setting and will form the basis for building international trials to be conducted worldwide.","Patients with relapsed or refractory acute myeloid leukemia",[42],{"label":40,"type":35,"description":43,"interventionNames":44},"All patients with relapsed or refractory acute myeloid leukemia",[45],"Other: Registration into the STREAM platform",[47],{"type":6,"name":48,"description":49,"armGroupLabels":50,"otherNames":35},"Registration into the STREAM platform","All patients fulfilling eligibility criteria will be registered into the STREAM platform. Baseline and follow up information will be recorded for each patient enrolled. Each patient will be followed up according to normal clinical practice up to 4 years.",[40],[52],{"name":53,"affiliation":54,"role":55},"Giovanni Martinelli, MD, Prof","University of Bologna","STUDY_CHAIR",[57,62],{"name":58,"role":59,"phone":60,"phoneExt":35,"email":61},"Oriana Nanni","CONTACT","+39 0543 739100","cc.ubsc@irst.emr.it",{"name":63,"role":59,"phone":35,"phoneExt":35,"email":64},"Impact-aml coord Impact-aml coord","impact-aml@irst.emr.it",[66,82,94,106,118,133,146,159,172,185,198,211,224,237,246,259,273,286,299,312,321,330,339,352,365,378,387,400,413,425,437,449,461,469,481,493,505,519,533,547],{"facility":67,"status":68,"city":69,"state":35,"zip":70,"country":71,"countryCode":72,"cosmosGeoPoint":73,"geoPoint":78,"contacts":79},"University Hospital Aachen","RECRUITING","Aachen","52074","Germany","DE",{"type":74,"coordinates":75},"Point",[76,77],6.08342,50.77664,{"lat":77,"lon":76},[80],{"name":81,"role":59,"phone":35,"phoneExt":35,"email":35},"Martina Crysandt, MD",{"facility":83,"status":68,"city":84,"state":35,"zip":85,"country":71,"countryCode":72,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"University Hospital Greifswald","Greifswald","17475",{"type":74,"coordinates":87},[88,89],13.40244,54.08905,{"lat":89,"lon":88},[92],{"name":93,"role":59,"phone":35,"phoneExt":35,"email":35},"Adrian Schwarzer, MD",{"facility":95,"status":68,"city":96,"state":35,"zip":97,"country":71,"countryCode":72,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"University Hospital Halle","Halle","06120",{"type":74,"coordinates":99},[100,101],11.97947,51.48158,{"lat":101,"lon":100},[104],{"name":105,"role":59,"phone":35,"phoneExt":35,"email":35},"Judith Schaffrath, MD",{"facility":107,"status":68,"city":108,"state":35,"zip":109,"country":71,"countryCode":72,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"University Hospital of Rostock","Rostock","18507",{"type":74,"coordinates":111},[112,113],12.14049,54.0887,{"lat":113,"lon":112},[116],{"name":117,"role":59,"phone":35,"phoneExt":35,"email":35},"Christian Junghanß, MD",{"facility":119,"status":68,"city":120,"state":121,"zip":122,"country":123,"countryCode":124,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"Policlinico Sant'Orsola-Malpighi","Bologna","BO","40138","Italy","IT",{"type":74,"coordinates":126},[127,128],11.33875,44.49381,{"lat":128,"lon":127},[131],{"name":132,"role":59,"phone":35,"phoneExt":35,"email":35},"Cristina Papayannidis, MD",{"facility":134,"status":68,"city":135,"state":136,"zip":137,"country":123,"countryCode":124,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"Ospedale \"A. Perrino\"","Brindisi","BR","72100",{"type":74,"coordinates":139},[140,141],17.93607,40.63215,{"lat":141,"lon":140},[144],{"name":145,"role":59,"phone":35,"phoneExt":35,"email":35},"Marina Aurora Urbano, MD",{"facility":147,"status":68,"city":148,"state":149,"zip":150,"country":123,"countryCode":124,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"ASST Spedali Civili","Brescia","BS","25123",{"type":74,"coordinates":152},[153,154],10.21472,45.53558,{"lat":154,"lon":153},[157],{"name":158,"role":59,"phone":35,"phoneExt":35,"email":35},"Erika Borlenghi, MD",{"facility":160,"status":68,"city":161,"state":162,"zip":163,"country":123,"countryCode":124,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Azienda Ospedaliera S. Croce e Carle","Cuneo","CN","12100",{"type":74,"coordinates":165},[166,167],7.54828,44.39071,{"lat":167,"lon":166},[170],{"name":171,"role":59,"phone":35,"phoneExt":35,"email":35},"Daniele Mattei, MD",{"facility":173,"status":68,"city":174,"state":175,"zip":176,"country":123,"countryCode":124,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"Ospedale Valduce","Como","CO","22100",{"type":74,"coordinates":178},[179,180],9.0832,45.80819,{"lat":180,"lon":179},[183],{"name":184,"role":59,"phone":35,"phoneExt":35,"email":35},"Mauro Turrini, MD",{"facility":186,"status":68,"city":187,"state":188,"zip":189,"country":123,"countryCode":124,"cosmosGeoPoint":190,"geoPoint":194,"contacts":195},"ASST Cremona","Cremona","CR","26100",{"type":74,"coordinates":191},[192,193],10.02129,45.13325,{"lat":193,"lon":192},[196],{"name":197,"role":59,"phone":35,"phoneExt":35,"email":35},"Alfredo Molteni, MD",{"facility":199,"status":68,"city":200,"state":201,"zip":202,"country":123,"countryCode":124,"cosmosGeoPoint":203,"geoPoint":207,"contacts":208},"AOU Universitaria Arcispedale Sant'Anna","Ferrara","FE","44124",{"type":74,"coordinates":204},[205,206],11.62057,44.83804,{"lat":206,"lon":205},[209],{"name":210,"role":59,"phone":35,"phoneExt":35,"email":35},"Gian Matteo Rigolin, MD",{"facility":212,"status":68,"city":213,"state":214,"zip":215,"country":123,"countryCode":124,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"IRCCS Ospedale Policlinico San Martino","Genova","GE","16132",{"type":74,"coordinates":217},[218,219],11.87211,45.21604,{"lat":219,"lon":218},[222],{"name":223,"role":59,"phone":35,"phoneExt":35,"email":35},"Matteo Emidio Dragani, MD",{"facility":225,"status":68,"city":226,"state":227,"zip":228,"country":123,"countryCode":124,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico","Milan","MI","20122",{"type":74,"coordinates":230},[231,232],12.59836,42.78235,{"lat":232,"lon":231},[235],{"name":236,"role":59,"phone":35,"phoneExt":35,"email":35},"Nicola Stefano Fracchiolla, MD",{"facility":238,"status":68,"city":226,"state":227,"zip":239,"country":123,"countryCode":124,"cosmosGeoPoint":240,"geoPoint":242,"contacts":243},"ASST Grande Ospedale Metropolitano Niguarda","20162",{"type":74,"coordinates":241},[231,232],{"lat":232,"lon":231},[244],{"name":245,"role":59,"phone":35,"phoneExt":35,"email":35},"Rosa Greco, MD",{"facility":247,"status":68,"city":248,"state":249,"zip":250,"country":123,"countryCode":124,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello","Palermo","PA","90146",{"type":74,"coordinates":252},[253,254],13.3636,38.1166,{"lat":254,"lon":253},[257],{"name":258,"role":59,"phone":35,"phoneExt":35,"email":35},"Antonino Mulè, MD",{"facility":260,"status":261,"city":262,"state":263,"zip":264,"country":123,"countryCode":124,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"Presidio Ospedaliero \"Santo Spirito\"","NOT_YET_RECRUITING","Pescara","PE","65124",{"type":74,"coordinates":266},[267,268],14.20283,42.4584,{"lat":268,"lon":267},[271],{"name":272,"role":59,"phone":35,"phoneExt":35,"email":35},"Prassede Salutari, MD",{"facility":274,"status":68,"city":275,"state":276,"zip":277,"country":123,"countryCode":124,"cosmosGeoPoint":278,"geoPoint":282,"contacts":283},"Ospedale Santa Maria della Misericordia","Perugia","PG","06156",{"type":74,"coordinates":279},[280,281],12.38878,43.1122,{"lat":281,"lon":280},[284],{"name":285,"role":59,"phone":35,"phoneExt":35,"email":35},"Maria Paola Martelli, MD",{"facility":287,"status":68,"city":288,"state":289,"zip":290,"country":123,"countryCode":124,"cosmosGeoPoint":291,"geoPoint":295,"contacts":296},"Ospedale Santa Maria delle Croci","Ravenna","RA","48121",{"type":74,"coordinates":292},[293,294],12.20121,44.41344,{"lat":294,"lon":293},[297],{"name":298,"role":59,"phone":35,"phoneExt":35,"email":35},"Giovanni Marconi, MD",{"facility":300,"status":68,"city":301,"state":302,"zip":303,"country":123,"countryCode":124,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"Fondazione Policlinico Tor Vergata","Roma","RM","00133",{"type":74,"coordinates":305},[306,307],11.10642,44.99364,{"lat":307,"lon":306},[310],{"name":311,"role":59,"phone":35,"phoneExt":35,"email":35},"Adriano Venditti, MD",{"facility":313,"status":68,"city":301,"state":302,"zip":314,"country":123,"countryCode":124,"cosmosGeoPoint":315,"geoPoint":317,"contacts":318},"Policlinico Umberto I","00161",{"type":74,"coordinates":316},[306,307],{"lat":307,"lon":306},[319],{"name":320,"role":59,"phone":35,"phoneExt":35,"email":35},"Saveria Capria, MD",{"facility":322,"status":68,"city":301,"state":302,"zip":323,"country":123,"countryCode":124,"cosmosGeoPoint":324,"geoPoint":326,"contacts":327},"Policlinico Universitario Fondazione Agostino Gemelli","00168",{"type":74,"coordinates":325},[306,307],{"lat":307,"lon":306},[328],{"name":329,"role":59,"phone":35,"phoneExt":35,"email":35},"Patrizia Chiusolo, MD",{"facility":331,"status":68,"city":301,"state":302,"zip":332,"country":123,"countryCode":124,"cosmosGeoPoint":333,"geoPoint":335,"contacts":336},"Ospedale Sant'Andrea","00189",{"type":74,"coordinates":334},[306,307],{"lat":307,"lon":306},[337],{"name":338,"role":59,"phone":35,"phoneExt":35,"email":35},"Agostino Tafuri, MD",{"facility":340,"status":68,"city":341,"state":342,"zip":343,"country":123,"countryCode":124,"cosmosGeoPoint":344,"geoPoint":348,"contacts":349},"Ospedale infermi di Rimini","Rimini","RN","47923",{"type":74,"coordinates":345},[346,347],12.56528,44.05755,{"lat":347,"lon":346},[350],{"name":351,"role":59,"phone":35,"phoneExt":35,"email":35},"Anna Maria Mianulli, MD",{"facility":353,"status":68,"city":354,"state":355,"zip":356,"country":123,"countryCode":124,"cosmosGeoPoint":357,"geoPoint":361,"contacts":362},"AOU San Giovanni di Dio e Ruggi d'Aragona","Salerno","SA","84131",{"type":74,"coordinates":358},[359,360],14.79328,40.67545,{"lat":360,"lon":359},[363],{"name":364,"role":59,"phone":35,"phoneExt":35,"email":35},"Bianca Serio, MD",{"facility":366,"status":68,"city":367,"state":368,"zip":369,"country":123,"countryCode":124,"cosmosGeoPoint":370,"geoPoint":374,"contacts":375},"AOU Città della Salute e della Scienza di Torino","Torino","TO","10126",{"type":74,"coordinates":371},[372,373],11.99138,44.88856,{"lat":373,"lon":372},[376],{"name":377,"role":59,"phone":35,"phoneExt":35,"email":35},"Ernesta Audisio, MD",{"facility":379,"status":68,"city":367,"state":368,"zip":380,"country":123,"countryCode":124,"cosmosGeoPoint":381,"geoPoint":383,"contacts":384},"AO Ordine Mauriziano","10128",{"type":74,"coordinates":382},[372,373],{"lat":373,"lon":372},[385],{"name":386,"role":59,"phone":35,"phoneExt":35,"email":35},"Alessandro Cignetti, MD",{"facility":388,"status":68,"city":389,"state":390,"zip":391,"country":123,"countryCode":124,"cosmosGeoPoint":392,"geoPoint":396,"contacts":397},"IOV Istituto Oncologico Veneto","Castelfranco Veneto","TV","31033",{"type":74,"coordinates":393},[394,395],11.92755,45.67146,{"lat":395,"lon":394},[398],{"name":399,"role":59,"phone":35,"phoneExt":35,"email":35},"Alessandra Sperotto, MD",{"facility":401,"status":68,"city":402,"state":403,"zip":404,"country":123,"countryCode":124,"cosmosGeoPoint":405,"geoPoint":409,"contacts":410},"ASST Valle Olona","Busto Arsizio","VA","21052",{"type":74,"coordinates":406},[407,408],8.84914,45.61128,{"lat":408,"lon":407},[411],{"name":412,"role":59,"phone":35,"phoneExt":35,"email":35},"Elisabetta Todisco, MD",{"facility":414,"status":261,"city":415,"state":35,"zip":416,"country":123,"countryCode":124,"cosmosGeoPoint":417,"geoPoint":421,"contacts":422},"Azienda Ospedaliero Universitaria Delle Marche","Ancona","60126",{"type":74,"coordinates":418},[419,420],13.5103,43.60717,{"lat":420,"lon":419},[423],{"name":424,"role":59,"phone":35,"phoneExt":35,"email":35},"Lorenzo Brunetti, MD",{"facility":426,"status":68,"city":427,"state":35,"zip":428,"country":123,"countryCode":124,"cosmosGeoPoint":429,"geoPoint":433,"contacts":434},"AOU Careggi","Florence","50019",{"type":74,"coordinates":430},[431,432],11.24626,43.77925,{"lat":432,"lon":431},[435],{"name":436,"role":59,"phone":35,"phoneExt":35,"email":35},"Francesco Mannelli, MD",{"facility":438,"status":68,"city":439,"state":35,"zip":440,"country":123,"countryCode":124,"cosmosGeoPoint":441,"geoPoint":445,"contacts":446},"IRST Istituto Romagnolo per lo Studio dei Tumori Dino Amadori","Meldola","47014",{"type":74,"coordinates":442},[443,444],12.0626,44.12775,{"lat":444,"lon":443},[447],{"name":448,"role":59,"phone":35,"phoneExt":35,"email":35},"Maria Benedetta Giannini, MD",{"facility":450,"status":68,"city":451,"state":35,"zip":452,"country":123,"countryCode":124,"cosmosGeoPoint":453,"geoPoint":457,"contacts":458},"Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli","Naples","80131",{"type":74,"coordinates":454},[455,456],14.26811,40.85216,{"lat":456,"lon":455},[459],{"name":460,"role":59,"phone":35,"phoneExt":35,"email":35},"Mario Annunziata, MD",{"facility":462,"status":261,"city":451,"state":35,"zip":452,"country":123,"countryCode":124,"cosmosGeoPoint":463,"geoPoint":465,"contacts":466},"Azienda Ospeldaliera Universitaria Federico II",{"type":74,"coordinates":464},[455,456],{"lat":456,"lon":455},[467],{"name":468,"role":59,"phone":35,"phoneExt":35,"email":35},"Fabrizio Pane, MD",{"facility":470,"status":68,"city":471,"state":35,"zip":472,"country":123,"countryCode":124,"cosmosGeoPoint":473,"geoPoint":477,"contacts":478},"AOU Maggiore della Carità","Novara","28100",{"type":74,"coordinates":474},[475,476],8.62118,45.44694,{"lat":476,"lon":475},[479],{"name":480,"role":59,"phone":35,"phoneExt":35,"email":35},"Monia Lunghi, MD",{"facility":482,"status":261,"city":483,"state":35,"zip":484,"country":123,"countryCode":124,"cosmosGeoPoint":485,"geoPoint":489,"contacts":490},"Azienda Ospedale-Università Padova","Padova","35100",{"type":74,"coordinates":486},[487,488],11.14261,44.38225,{"lat":488,"lon":487},[491],{"name":492,"role":59,"phone":35,"phoneExt":35,"email":35},"Federica Lessi, MD",{"facility":494,"status":68,"city":495,"state":35,"zip":496,"country":123,"countryCode":124,"cosmosGeoPoint":497,"geoPoint":501,"contacts":502},"Ospedale San Bortolo","Vicenza","36100",{"type":74,"coordinates":498},[499,500],11.5475,45.54672,{"lat":500,"lon":499},[503],{"name":504,"role":59,"phone":35,"phoneExt":35,"email":35},"Davide Facchinelli, MD",{"facility":506,"status":68,"city":507,"state":35,"zip":508,"country":509,"countryCode":510,"cosmosGeoPoint":511,"geoPoint":515,"contacts":516},"The Hospital of Lithuanian University of Health Sciences Kauno Klinikos","Kaunas","50161","Lithuania","LT",{"type":74,"coordinates":512},[513,514],23.90909,54.90156,{"lat":514,"lon":513},[517],{"name":518,"role":59,"phone":35,"phoneExt":35,"email":35},"Rolandas Gerbutavičius, MD",{"facility":520,"status":68,"city":521,"state":35,"zip":522,"country":523,"countryCode":524,"cosmosGeoPoint":525,"geoPoint":529,"contacts":530},"University Clinical Center in Gdańsk","Gdansk","80-214","Poland","PL",{"type":74,"coordinates":526},[527,528],18.64912,54.35227,{"lat":528,"lon":527},[531],{"name":532,"role":59,"phone":35,"phoneExt":35,"email":35},"Karolina Bełdzińska-Gądek, MD",{"facility":534,"status":68,"city":535,"state":35,"zip":536,"country":537,"countryCode":538,"cosmosGeoPoint":539,"geoPoint":543,"contacts":544},"Fundeni Clinical Institute","Bucharest","022328","Romania","RO",{"type":74,"coordinates":540},[541,542],26.10626,44.43225,{"lat":542,"lon":541},[545],{"name":546,"role":59,"phone":35,"phoneExt":35,"email":35},"Daniel Coriu, MD",{"facility":548,"status":68,"city":549,"state":35,"zip":550,"country":551,"countryCode":552,"cosmosGeoPoint":553,"geoPoint":557,"contacts":558},"University Hospital La Fe","Valencia","46026","Spain","ES",{"type":74,"coordinates":554},[555,556],-0.37966,39.47391,{"lat":556,"lon":555},[559],{"name":560,"role":59,"phone":35,"phoneExt":35,"email":35},"Pau Montesino, MD",{"type":562,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR",[564,566,568,571,573,576,578,580,582,584,585,587,589,592,594,596],{"name":565,"class":6},"Hospital Vall d'Hebron",{"name":567,"class":6},"Cyprus Institute of Neurology and Genetics",{"name":569,"class":570},"European LeukemiaNet","NETWORK",{"name":572,"class":6},"Fundacion Para La Investigacion Hospital La Fe",{"name":574,"class":575},"Ostedusche Hematology and Oncology Study Group","UNKNOWN",{"name":577,"class":6},"Ospedale Pediatrico Bambin Gesù",{"name":579,"class":6},"Czech Lymphoma Study Group",{"name":581,"class":6},"Charite University, Berlin, Germany",{"name":583,"class":6},"Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León",{"name":54,"class":6},{"name":586,"class":6},"Hannover Medical School",{"name":588,"class":6},"German Society for Pediatric Oncology and Hematology GPOH gGmbH",{"name":590,"class":591},"Toscana Life Sciences Sviluppo s.r.l.","INDUSTRY",{"name":593,"class":6},"Lithuanian University of Health Sciences",{"name":595,"class":6},"Gruppo Italiano Malattie EMatologiche dell'Adulto",{"name":597,"class":575},"Time.Lex","100551356","master-framework-for-relapse-or-refractory-acute-myeloid-leukemia-100551356",false,"NCT06459024","Master Framework For Relapse or Refractory Acute Myeloid Leukemia","Master Framework For Relapse or Refractory Acute Myeloid Leukemia- IMPACT STREAM - A Prospective Observational Study of Treatment Outcomes","IMPACT STREAM","Inclusion Criteria:\n\n* Patients with AML diagnosis according to WHO2022 or ICC2022\n* Treatment failure (i.e. relapse, refractory or progression, including MRD) according to ELN2022 criteria\n* Participant or his\u002Fher legal representative is willing and able to give informed consent for participation in the study\n\nExclusion Criteria:\n\n* Patients included in clinical trials may be enrolled except where otherwise specified in the experimental protocol.","ALL","6 Years",{"count":609,"type":610},4000,"ESTIMATED","OBSERVATIONAL","This is an observational (non-interventional), prospective, cohort study that will collects data from patients diagnosed with relapsed or refractory acute myeloid leukemia afferent to the participanting clinical sites",[614,615],"Acute Myeloid Leukemia, in Relapse","Acute Myeloid Leukemia Refractory",[617,618,619,620],"Relapsed","Refractory","Acute Myeloid Leukemia","Framework","2026-08-13",{"date":623,"type":624},"2026-08-14","ACTUAL",{"date":626,"type":624},"2024-06-28",{"date":628,"type":610},"2032-07",{"name":5,"class":6},40]