[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655695":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":26,"interventions":20,"overallOfficials":20,"centralContacts":36,"locations":42,"responsibleParty":60,"collaborators":62,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":20,"maxAge":20,"enrollmentInfo":76,"targetDuration":20,"studyType":79,"phases":20,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":94,"whyStopped":20,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Uppsala University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Serious adverse events occurring after a surgical, or medical procedure requiring anesthetic.","A composite of adverse events consisting of Death, Unplanned ICU-admission, Myocardial arrest (ICD10: I46), Myocardial infarction (ICD10: I21-22), Pneumonia (ICD10: J13-16, J18, J85, J86, A481), and Anaphylaxis (ICD10: T782, T805, T886) Up until 30 days after the procedure.","Days 30 after a qualifying procedure.",[14,16],{"measure":10,"description":15,"timeFrame":12},"The variables in the composite outcome analyzed one by one.",{"measure":17,"description":18,"timeFrame":19},"Adverse events registered at the post anesthesia care unit (PACU)","Tachy-\u002Fbradycardia, arrythmia, angina, heart failure, hypo-\u002Fhypertension, and unexpected bleeding registered in the Swedish Perioperative Register (SPOR) from patients originating from the Swedish cohort.","Hours 24 after a qualifying procedure.",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"COHORT","RETROSPECTIVE","Background Perioperative complications may be associated with both suffering for the affected individuals, and a high cost for society. Available means for identifying individuals at risk should be considered.\n\nObjective To investigate whether patients with MC1R variants (Asp84Glu, Arg142His Arg151Cys, Tyr152Ochre, Ile155Thr, Arg160Trp, Arg213Trp, Asp294His, or Arg306His) associated with red hair, or having a red hair phenotype have an increased incidence of anesthesia related perioperative complications.\n\nMethod This is a retrospective registry-based study including patients from one Swedish cohort (MAICS), and one British cohort (UKBB). MAICS is aggregation of four different cohorts; PronMed, Epihealth, Simpler, and the Swedish Twin Registry (STR). The Patients are selected from the Swedish National Patient Registry (NPR), and the Hospital Episode Statistics (HES)\u002FNHS England using surgical and medical procedure codes known for requiring an anesthetic management in the form of general anesthesia, spinal\u002Fepidural anesthesia or regional anesthesia.\n\nEligible patients are associated with genotype data, and stratified into either homozygote\u002Fcompound heterozygote, heterozygote, or wildtype to be able to assess whether a dose-response relationship exists between the different levels of exposures. From UKBB, a separate analysis of the association between red hair phenotype and perioperative complications is performed.\n\nOutcome ascertainment, and the defining of cases and non-cases, is perfomed using healthcare linkage to Swedish Perioperative Registry (SPOR), Swedish Intensive Care Register (SIR), National cause of death registry (DORS), Statistics Sweden, and UKBB.\n\nThe results will be analyzed using a statistical mixed effects model, adjusted for age, sex, timing of surgery during the study period, and socioeconomic factors. The results of the genotype analysis from the two cohorts will be meta-analyzed.","The population consists of all available patients registered in either NPR\u002FSweden or HES\u002FUKBB with a qualifying procedure code, and having been genotyped for a defined MC1R variant.",[27,30,33],{"label":28,"type":20,"description":29,"interventionNames":20},"Exposure (high","Individuals from either MAICS or UKBB being homozygote\u002Fcompound heterozygote for MC1R mutations, OR individuals from UKBB consistently reporting red hair phenotype.",{"label":31,"type":20,"description":32,"interventionNames":20},"Exposure (intermediate)","Individuals from either MAICS or UKBB being heterozygote for MC1R mutations, OR individuals from UKBB with diverse reporting of having red hair phenotype.",{"label":34,"type":20,"description":35,"interventionNames":20},"Non-exposure (control)","Individuals from either the MAICS or the UKBB databases carrying a MC1R wildtype, OR individuals from UKBB reporting a hair color other than red.",[37],{"name":38,"role":39,"phone":40,"phoneExt":20,"email":41},"Miklós Lipcsey, MD, PhD","CONTACT","0046 18 611 0000","miklos.lipcsey@uu.se",[43],{"facility":44,"status":20,"city":45,"state":20,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Uppsala University, Department of Surgical Sciences","Uppsala","75185","Sweden","SE",{"type":50,"coordinates":51},"Point",[52,53],17.63889,59.85882,{"lat":53,"lon":52},[56,58],{"name":38,"role":39,"phone":57,"phoneExt":20,"email":41},"0046 18 6110000",{"name":38,"role":59,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"type":61,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[63,65],{"name":64,"class":6},"County Council of Gavleborg",{"name":66,"class":6},"Dalarna County Council, Sweden","100655695","mc1r-mutations-associated-with-red-hair-and-perioperative-anesthesia-complications-100655695",false,"NCT07815431","MC1R Mutations Associated With Red Hair and Perioperative Anesthesia Complications","The Presence of Red Hair Associated MC1R Mutations and the Incidence of Perioperative Anesthesia Complications: A Cohort Study","MARPAC","Inclusion Criteria:\n\n* A qualifying surgical procedure requiring specified anesthetic management.\n* A qualifying medical procedure requiring specified anesthetic management.\n* Caucasian origin.\n\nExclusion Criteria:\n\n* None specified.","ALL",{"count":77,"type":78},100000,"ESTIMATED","OBSERVATIONAL","The study aims to investigate whether patients with Melanocortin-1 receptor (MC1R) mutations, associated with red hair, or having a red hair phenotype, have a higher incidence of anesthesia-related perioperative complications. Genomic data from patients that have undergone a surgical or medical procedure, requiring an anesthetic management are extracted from two cohorts - a Swedish (Merged Anaesthesia and Intensive Care Cohort in Sweden (MAICS)), and a British (UK Biobank UKBB)), and linked to relevant healthcare registries. The outcome variables studied are statistically adjusted for age, gender, timing of procedure during the study period, and socioeconomic factors.",[82,83,84,85],"Anaesthesia Complication","Perioperative Adverse Events","Red Hair","Melanocortin 1 Receptor",[87,88,89,90,91,92,93],"Red hair","Anesthesia","Surgery","Perioperative complications","Adverse events","Melanocortin 1 receptor mutation","MC1R","NOT_YET_RECRUITING","2026-09-10",{"date":97,"type":98},"2026-09-11","ACTUAL",{"date":100,"type":78},"2026-09",{"date":102,"type":78},"2026-12",{"name":5,"class":6},1]