[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653921":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":33,"studyPopulation":22,"armGroups":34,"interventions":63,"overallOfficials":77,"centralContacts":82,"locations":88,"responsibleParty":102,"collaborators":22,"id":105,"slug":106,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":22,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":113,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":22,"studyType":119,"phases":120,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":132,"whyStopped":22,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":141},{"fullName":5,"class":6},"National University of Singapore","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":22},[9,13],{"measure":10,"description":11,"timeFrame":12},"Changes in metabolites found in plasma (plasma metabolomics)","Targeted metabolomics profiling of plasma will be conducted using liquid chromatography-mass spectrometry\u002Fmass spectrometry (LC-MS\u002FMS)","Baseline, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes",{"measure":14,"description":15,"timeFrame":16},"Changes in metabolites found in urine (urinary metabolomics)","Targeted metabolomics profiling of urine will be conducted liquid chromatography-mass spectrometry\u002Fmass spectrometry (LC-MS\u002FMS)","Baseline and 300 minutes",[18],{"measure":19,"description":20,"timeFrame":21},"Appetite","The Appetite Visual Analogue Scale (VAS) questionnaire will be administered, with participants rating five appetite-related outcomes, i.e. desire to eat, hunger, fullness, satisfaction, and prospective food consumption. Each response will be measured on a 100-mm visual analogue scale and scored from 0 to 100, with higher scores indicate a greater intensity of the outcomes being assessed, i.e. greater desire to eat, greater hunger, greater fullness, greater satisfaction, or a greater perceived amount of food that could be consumed.","Baseline, 60, 120, 180, 240, 300 minutes",null,{"allocation":24,"interventionModel":25,"interventionModelDescription":22,"primaryPurpose":26,"observationalModel":22,"timePerspective":22,"maskingInfo":27},"RANDOMIZED","CROSSOVER","PREVENTION",{"masking":28,"maskingDescription":22,"whoMasked":29},"TRIPLE",[30,31,32],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR","This study is a randomised crossover trial involving 16 participants. It comprises one screening visit and five test visits, during which participants will consume intervention drinks containing primarily (1) maltodextrin, (2) whey protein isolate, (3) soy protein isolate, (4) bead-milled microalgae, or (5) non-bead-milled microalgae in a randomised order. The study aims to investigate and compare acute postprandial metabolite responses following the consumption of bead-milled and non-bead-milled microalgae, as well as whey and soy protein isolates, in Singaporean adults.",[35,41,47,52,57],{"label":36,"type":37,"description":38,"interventionNames":39},"Bead-milled microalgae","EXPERIMENTAL","Consume a 400 mL drink containing 20 g protein equivalent of bead-milled microalgae",[40],"Dietary Supplement: Bead-milled microalgae",{"label":42,"type":43,"description":44,"interventionNames":45},"Non-bead-milled microalgae","ACTIVE_COMPARATOR","Consume a 400 mL drink containing 20 g protein equivalent of non-bead-milled microalgae",[46],"Dietary Supplement: Non-bead-milled microalgae",{"label":48,"type":43,"description":49,"interventionNames":50},"Whey protein isolate","Consume a 400 mL drink containing 20 g protein equivalent of whey protein isolate",[51],"Dietary Supplement: Whey protein isolate",{"label":53,"type":43,"description":54,"interventionNames":55},"Soy Protein Isolate","Consume a 400 mL drink containing 20 g protein equivalent of soy protein isolate",[56],"Dietary Supplement: Soy protein isolate",{"label":58,"type":59,"description":60,"interventionNames":61},"Maltodextrin","PLACEBO_COMPARATOR","Consume a 400 mL drink containing maltodextrin matched for the energy content of 20 g protein",[62],"Dietary Supplement: Maltodextrin (Placebo)",[64,67,69,71,74],{"type":65,"name":36,"description":38,"armGroupLabels":66,"otherNames":22},"DIETARY_SUPPLEMENT",[36],{"type":65,"name":42,"description":44,"armGroupLabels":68,"otherNames":22},[42],{"type":65,"name":48,"description":49,"armGroupLabels":70,"otherNames":22},[48],{"type":65,"name":72,"description":54,"armGroupLabels":73,"otherNames":22},"Soy protein isolate",[53],{"type":65,"name":75,"description":60,"armGroupLabels":76,"otherNames":22},"Maltodextrin (Placebo)",[58],[78],{"name":79,"affiliation":80,"role":81},"Jung Eun Kim, Ph.D., R.D.","National University of Singapore, Department of Food Science and Technology","PRINCIPAL_INVESTIGATOR",[83],{"name":84,"role":85,"phone":86,"phoneExt":22,"email":87},"Marven Ng, B.Sc.","CONTACT","(+65) 8816 9977","ngmarven@u.nus.edu",[89],{"facility":90,"status":22,"city":91,"state":22,"zip":22,"country":91,"countryCode":92,"cosmosGeoPoint":93,"geoPoint":98,"contacts":99},"NUS, Department of Food Science and Technology, 1 Science Drive 3, Block S13, #03-07, Singapore, 117550","Singapore","SG",{"type":94,"coordinates":95},"Point",[96,97],103.85007,1.28967,{"lat":97,"lon":96},[100,101],{"name":84,"role":85,"phone":86,"phoneExt":22,"email":87},{"name":79,"role":81,"phone":22,"phoneExt":22,"email":22},{"type":81,"investigatorFullName":103,"investigatorTitle":104,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Jung Eun Kim","Associate Professor","100653921","measurement-of-acute-metabolite-changes-following-consumption-of-microalgae-drinks-100653921",false,"NCT07791420","Measurement of Acute Metabolite Changes Following Consumption of Microalgae Drinks","Measurement of Acute Metabolite Changes Following Consumption of Unprocessed and Processed Microalgae: A Randomized Crossover Trial","Inclusion Criteria:\n\n* English-literate and able to give informed consent\n* Singaporean Chinese Adults aged 21 to 60 (inclusive)\n* Body mass index of 18.5 to 23.0 kg\u002Fm\\^2 (inclusive)\n* Healthy (Based on results from screening session)\n\nExclusion Criteria:\n\n* Currently participating in another clinical study that involves altering the regular diet and\u002For involves consuming a dietary supplement or investigated food product as an intervention\n* High blood pressure (≥ 140\u002F90 mmHg)\n* Underlying health conditions that may affect metabolic functions\n* Consuming amino acid or protein supplements, or protein drinks, regularly (i.e., more than three times a week) for the past 3 months, and not willing to discontinue usage 3 months before and during the study duration\n* Weight change \\> 3 kg in the past 3 months\n* Weight \\\u003C 50 kg\n* Exercising vigorously over the past 3 months (i.e., engaging in high-intensity exercises for more than 3 hours a week, where high-intensity exercises leave one out of breath and unable to talk or sing during the workout)\n* Current smokers or have quit smoking for less than 5 years\n* Drinking \\> 2 alcoholic drinks per day (i.e., one drink is defined as either 150 ml of wine, 340 ml of beer\u002Fcider or 45 ml of distilled spirit)\n* If drinking ≤ 2 alcoholic drinks per day, not willing to stop consumption of alcoholic beverages two days before and on the day of the test visits\n* Not willing to stop consumption of caffeinated beverages 10 to 12 houFrs before and on the day of the test visits\n* Currently on a specialised diet (e.g., Halal, vegetarian, vegan, weight loss diet)\n* Had serious food allergies in the past, or having intolerance, sensitivities or allergies to any of the following: seaweed or algae and their derived products, milk\u002Fdairy products (e.g., whey), starch\u002Fstarch-derived products (e.g., rice, corn, wheat, potato), soy\u002Fsoy-derived products, gluten, eggs, nuts, peanuts, fish and crustaceans\n* Disease or impairment of the kidney and\u002For liver\\*\n* Currently diagnosed with diabetes\\*, gastrointestinal issues (e.g., lactose intolerance, irritable bowel syndrome), gout and\u002For G6PD deficiency\n* Taking antibiotics 2 weeks prior to study participation\n* Taking anti-hypertensive or cholesterol-lowering drugs for less than 3 years unless medically declared by an official doctor to be in stable condition\n* Poor peripheral venous access based on past experiences with blood drawing\n* Individuals with anemia and\u002For blood clotting disorders\n* Donated blood within the 12 weeks prior to study participation\n* Individuals with pacemaker or related electrical medical devices\n* Pregnant, lactating, or planning pregnancy in the next 6 months",true,"ALL","21 Years","60 Years",{"count":117,"type":118},20,"ESTIMATED","INTERVENTIONAL",[121],"NA","Protein consumption is essential for various physiological processes, with microalgae and plant proteins gaining increasing attention due to their health benefits. To better understand how different protein types and processing methods impact health outcomes, this study aims to analyse the metabolite changes in response to different protein sources.",[124,125],"Protein Absorption and Amino Acid Availability","Metabolomics",[127,128,125,129,130,131],"Protein absorption","Amino acid availability","Processing","Microalgae","Acute","NOT_YET_RECRUITING","2026-08-28",{"date":135,"type":136},"2026-09-01","ACTUAL",{"date":135,"type":118},{"date":139,"type":118},"2027-12-31",{"name":5,"class":6},1]