[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649855":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":37,"locations":47,"responsibleParty":63,"collaborators":29,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":29,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":29,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":89,"whyStopped":29,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Medical College of Wisconsin","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Yoga","EXPERIMENTAL","Participants will engage in 10 weekly IY classes",[13],"Behavioral: Iyengar Yoga",{"label":15,"type":16,"description":17,"interventionNames":18},"Socialization Control","ACTIVE_COMPARATOR","Participants will engage in 10 weekly socialization control group sessions",[19],"Behavioral: Health Education Control",{"label":21,"type":6,"description":21,"interventionNames":22},"Waitlist Control",[23],"Other: Waitlist Control to Crossover",[25,30,33],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","Iyengar Yoga",[9],null,{"type":26,"name":31,"description":17,"armGroupLabels":32,"otherNames":29},"Health Education Control",[15],{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":29},"Waitlist Control to Crossover","Upon Step 1 study completion (week 10), participants in this group who continue to meet PGD criteria on the SCIP will enter Step 2 phase",[21],[38,43],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},"Joseph Goveas, MD","CONTACT","414-955-8970","jgoveas@mcw.edu",{"name":44,"role":40,"phone":45,"phoneExt":29,"email":46},"Keri Hainsworth, PhD","414-852-9046","khainsworth@mcw.edu",[48],{"facility":5,"status":29,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Milwaukee","Wisconsin","53226","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-87.90647,43.0389,{"lat":58,"lon":57},[61],{"name":44,"role":40,"phone":45,"phoneExt":29,"email":62},"khainswo@mcw.edu",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Joseph Goveas","Professor, Department of Psychiatry and Behavioral Medicine","100649855","mechanisms-underlying-late-life-prolonged-grief-disorder-100649855",false,"NCT07738133","Mechanisms Underlying Late-Life Prolonged Grief Disorder","Probing Brain Network Mechanisms Underlying Late-Life Prolonged Grief Disorder","Inclusion Criteria:\n\n* Male or female greater than or equal to 40 years of age\n* Bereavement \\>6 months\n* Score greater than or equal to 25 on the Inventory of Complicated Grief (ICG)\n* Presence of PGD (subsyndromal and syndromal)\n* Adequate visual and auditory acuity\n\nExclusion Criteria:\n\n* Delirium\u002Funstable medical conditions\n* Lifetime history of neurological illnesses: seizures, stroke, dementia of any -etiology, severe head injury, brain tumor or surgery\n* Serious back, joint or neck injuries within the past 3 months\n* Currently practicing yoga\n* Gross structural abnormalities on T1-weighted images\n* Lifetime history of the following psychiatric disorders: bipolar or psychotic -disorders, including psychotic depression\n* Current alcohol\u002Fdrug abuse or dependence\n* Magnetic resonance imaging (MRI) contraindications\n* Acute suicidality","ALL","40 Years","89 Years",{"count":78,"type":79},126,"ESTIMATED","INTERVENTIONAL",[82],"NA","After losing a loved one, most successfully navigate acute grief and adapt to the loss within about 1 year, but in about 10%, prolonged grief disorder (PGD) ensues. This study is anticipated to provide novel evidence regarding the neurobiological mechanisms of PGD in older adults. The biological alterations identified here could provide targets to elucidate how currently available therapies work and inform novel mechanism-based interventions for treating late-life PGD.",[85],"Prolonged Grief Disorder",[87,9,88],"Grief","Health Education","NOT_YET_RECRUITING","2026-07-28",{"date":92,"type":93},"2026-07-31","ACTUAL",{"date":95,"type":79},"2027-01",{"date":97,"type":79},"2031-06",{"name":5,"class":6},1]