[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650847":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":32,"centralContacts":37,"locations":44,"responsibleParty":58,"collaborators":42,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":42,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":42,"overallStatus":80,"whyStopped":42,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Session A: Amplitude Modulation Specificity","EXPERIMENTAL","hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order:\n\n* in-phase mTI (10 Hz)\n* mixed unipolar+HF\n* HF control (no envelope)\n* SHAM PRE 3 min \u002F STIM 3 min \u002F POST 3 min per condition\n\nAdverse events assessment",[13],"Device: TES-TI with hdEEG",{"label":15,"type":10,"description":16,"interventionNames":17},"Session B: Benchmarking","hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order:\n\n* in-phase mTI (10 Hz)\n* unipolar TES-TI 5 mA\n* unipolar TES-TI 8 mA\n* SHAM PRE 3 min \u002F STIM 3 min \u002F POST 3 min per condition\n\nAdverse events assessment",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Session C: Frequency Dependence","hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order:\n\n* in-phase mTI at 10 Hz\n* in-phase mTI at 50 Hz\n* in-phase mTI at 130 Hz\n* SHAM PRE 3 min \u002F STIM 3 min \u002F POST 3 min per condition\n\nAdverse events assessment",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DEVICE","TES-TI with hdEEG","4 conditions per session. Each condition will follow a standardized block structure consisting of 3 minutes pre-stimulation baseline, 3 minutes stimulation, and 3 minutes post-stimulation recording (PRE, STIM, POST)",[9,15,19],[29,30,31],"mTI","transcranial electrical stimulation","High-Density Electroencephalography",[33],{"name":34,"affiliation":35,"role":36},"Larissa Albantakis, PhD","UW School of Medicine and Public Health","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"MINT Study Team","CONTACT","608-263-4313",null,"mint@psychiatry.wisc.edu",[45],{"facility":46,"status":42,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":42},"University of Wisconsin - Madison","Madison","Wisconsin","53706","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-89.40123,43.07305,{"lat":56,"lon":55},{"type":59,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100650847","mechanistic-validation-of-human-multipolar-tes-ti-amplitude-modulation-frequency-and-benchmarking-100650847",false,"NCT07752745","Mechanistic Validation of Human Multipolar TES-TI: Amplitude Modulation, Frequency, and Benchmarking","MINT","Inclusion Criteria:\n\n* Medically healthy (based on self-report and study team review)\n* U.S. citizen or holding permanent resident status\n* English-speaking (able to provide consent and complete questionnaires)\n\nExclusion Criteria:\n\n* Current or past history of clinically significant neurological disorder or acquired neurological disease (e.g., stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified on the structural MRI)\n* History of inpatient psychiatric hospitalization\n* History of head trauma resulting in prolonged loss of consciousness; or a history of \\>3 grade I concussions\n* Current poorly controlled headaches, including intractable or frequent migraines\n* Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)\n* History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist\n* Possible pregnancy or plan to become pregnant in the next 6 months (self reported)\n* Any metal in the head\n* Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator)\n* Dental implants\n* Permanent retainers\n* Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out before the study sessions\n* Any head coverings or headdress that participant feels uncomfortable removing for the purposes of study sessions\n* Current use of medications known to substantially lower seizure threshold, specifically chlorpromazine, clozapine, bupropion, clomipramine, or maprotiline; or other medications at doses known to substantially lower seizure threshold in the judgment of the PI\n* Active scalp lesions, broken skin, or skin conditions at planned electrode sites that would preclude safe electrode application\n* Claustrophobia (a fear of small or closed places)\n* Back problems that would prevent lying flat for up to two hours",true,"ALL","18 Years","50 Years",{"count":72,"type":73},24,"ESTIMATED","INTERVENTIONAL",[76],"NA","This study is to find out whether and how a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity in healthy adults. A structural MRI scan will be used to customize where the stimulation electrodes are placed for each participant to deliver TES-TI during three afternoon sessions at rest with eyes closed. Brain activity is recorded with high-density EEG. Up to 24 participants will be enrolled and on study for 3 to 12 weeks.",[79],"Transcranial Electric Stimulation","NOT_YET_RECRUITING","2026-08-03",{"date":83,"type":84},"2026-08-07","ACTUAL",{"date":86,"type":73},"2026-09",{"date":88,"type":73},"2028-02",{"name":5,"class":6},1]