[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648473":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":41,"centralContacts":45,"locations":11,"responsibleParty":50,"collaborators":11,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":11,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":11,"enrollmentInfo":62,"targetDuration":11,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":11,"overallStatus":73,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":11},{"fullName":5,"class":6},"Boston University Charles River Campus","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Peak Frequency","EXPERIMENTAL",null,[13],"Device: Peak Frequency",{"label":15,"type":10,"description":11,"interventionNames":16},"Phase Lag",[17],"Device: Phase Lag",{"label":19,"type":10,"description":11,"interventionNames":20},"Peak Frequency + Phase Lag",[21],"Device: Peak Frequency + Phase Lag",{"label":23,"type":10,"description":11,"interventionNames":24},"Non-Adaptive",[25],"Device: Non-Adpative",[27,31,34,37],{"type":28,"name":9,"description":29,"armGroupLabels":30,"otherNames":11},"DEVICE","Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual peak frequency with the goal of modulating levels of neuronal excitability.",[9],{"type":28,"name":15,"description":32,"armGroupLabels":33,"otherNames":11},"Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual phase lag with the goal of modulating levels of neuronal excitability.",[15],{"type":28,"name":19,"description":35,"armGroupLabels":36,"otherNames":11},"Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual peak frequency and phase lag with the goal of modulating levels of neuronal excitability.",[19],{"type":28,"name":38,"description":39,"armGroupLabels":40,"otherNames":11},"Non-Adpative","Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp not tailored to individual peak frequency or phase lag with the goal of modulating levels of neuronal excitability.",[23],[42],{"name":43,"affiliation":5,"role":44},"Robert Reinhart, PhD","PRINCIPAL_INVESTIGATOR",[46],{"name":43,"role":47,"phone":48,"phoneExt":11,"email":49},"CONTACT","(617) 353-9481","rmgr@bu.edu",{"type":51,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100648473","memory-enhancement-in-aging-with-closed-loop-tacs-100648473",false,"NCT07722598","Memory Enhancement in Aging With Closed-Loop tACS","Personalized Memory Enhancement in Aging: Pattern-Optimized tACS With Closed-Loop Precision Modulation","Inclusion Criteria:\n\n* 65 years of age or older\n* normal or corrected-to-normal vision\n* color vision\n\nExclusion Criteria:\n\n* pregnant\n* metal implants in head\n* implanted electronic devices\n* history of neurological problems or head injury\n* skin sensitivity\n* claustrophobia\n* dementia (normal Montreal Cognitive Assessment \\> 25)\n* depression (normal Geriatric Depression Scale \\\u003C 10)\n* history of psychosis\n* cognitive deficits (MoCA\\>25)\n* any psychoactive medication",true,"ALL","65 Years",{"count":63,"type":64},160,"ESTIMATED","INTERVENTIONAL",[67],"NA","This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.",[70,71,72],"Aging","Noninvasive Brain Stimulation","Memory","NOT_YET_RECRUITING","2026-07-21",{"date":76,"type":77},"2026-07-23","ACTUAL",{"date":79,"type":64},"2028-05-01",{"date":81,"type":64},"2031-01-31",{"name":5,"class":6}]